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由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen 41 kDa
交差性
mouse, rat, human
濃度
~1 mg/mL
テクニック
ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... F2RL3(9002)
詳細
Anti-PAR4 Antibody detects endogenous levels of total PAR4 protein.
F2R-like thrombin or trypsin receptor 3/coagulation factor 2 receptor-like 3 (F2RL3) gene codes for protease-activated receptor 4 (PAR4) protein. PAR4 belongs to the G protein-coupled receptors (GPCRs) family. It is expressed at high levels in the lungs, pancreas, thyroid, testis, and small intestine. PAR4 gene is located on human chromosome 19p12. Anti-PAR4 antibody detects endogenous levels of total PAR4 protein.
免疫原
The antiserum was produced against synthesized peptide derived from human PAR4.
Immunogen Range: 29-78
Immunogen Range: 29-78
アプリケーション
Anti-PAR4 antibody produced in rabbit has been used in immunoblotting (1:1000).
生物化学的／生理学的作用
Protease-activated receptor 4 (PAR4) protein is involved in vascular inflammation. It is necessary for a stable thrombus as it mediates persistent thrombin signaling in platelets. PAR4 aids pro-inflammatory actions by interacting with the bradykinin B2 receptor. It is linked to renal function and the development of chronic kidney disease (CKD).
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
最新バージョンのいずれかを選択してください：
Gamariel Rwibasira Rudinga et al.
International journal of molecular sciences, 19(2) (2018-02-15)
Cardiovascular diseases (CVDs) are currently among the leading causes of death worldwide. Platelet aggregation is a key cellular component of arterial thrombi and major cause of CVDs. Protease-activated receptors (PARs), including PAR1, PAR2, PAR3 and PAR4, fall within a subfamily
W F Xu et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(12), 6642-6646 (1998-06-17)
Protease-activated receptors 1-3 (PAR1, PAR2, and PAR3) are members of a unique G protein-coupled receptor family. They are characterized by a tethered peptide ligand at the extracellular amino terminus that is generated by minor proteolysis. A partial cDNA sequence of
Shailaja Mahajan-Thakur et al.
Journal of leukocyte biology, 96(4), 611-618 (2014-07-06)
Thrombin is not only a central factor in blood coagulation but also stimulates inflammatory processes, including monocyte responses, via activation of PARs. The signaling lipid S1P is a major determinant of monocyte function. Here, we established an interaction between S1P
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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