おすすめの製品
由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
化学種の反応性
mouse, human
テクニック
indirect ELISA: suitable
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... ANO1(55107)
詳細
Transmembrane member 16A (TMEM16A) or Anoctamin1 (Ano1) is a calcium-activated chloride channel. It is expressed in the interstitial cells of Cajal (ICC) in the gastrointestinal tract. The gene encoding this protein is localized on human chromosome 11q13.3.
免疫原
TMEM16A antibody was raised against a 17 amino acid peptide from near the amino terminus of human TMEM16A.
生物化学的／生理学的作用
Transmembrane member 16A (TMEM16A) or Ano1 is crucial for normal electrical slow waves and for the proliferation of interstitial cells of Cajal (ICC). The protein has a role in smooth muscle contraction, salivary secretion and cardiac and neuronal excitability. TMEM16A has been associated with head and neck squamous cell carcinoma and breast cancer.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
関連事項
The action of this antibody can be blocked using blocking peptide SBP3500318.
物理的形状
PBS（0.02％ アジ化ナトリウム含有）
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保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
EAVK segment "c" sequence confers Ca2+-dependent changes to the kinetics of full-length human Ano1.
Strege PR
American Journal of Physiology: Gastrointestinal and Liver Physiology (2017)
TMEM16A/ANO1 suppression improves response to antibody-mediated targeted therapy of EGFR and HER2/ERBB2.
Kulkarni S
Genes Chromosomes Cancer (2017)
GDD1 Is Identical to TMEM16E, a Member of the TMEM16 Family
Masuko K
American Journal of Human Genetics (2004)
Meiyan Sun et al.
Endocrinology, 155(8), 2787-2796 (2014-05-16)
Calcium-dependent chloride conductances have been described in chicken and human granulosa cells (GCs) and may be involved in steroidogenesis. However, the molecular identities of corresponding chloride channels remain unknown. The purpose of this study was to explore the expression and
Xuan-Yu Wang et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(9), 1298-1310 (2014-07-22)
Interstitial cells of Cajal associated with the submuscular plexus (ICC-SMP) generate omnipresent slow-wave activity in the colon and are associated with prominent motor patterns. Our aim was to investigate colon motor dysfunction in W/W(v) mice in which the ICC are
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