S8751

スルファグアニジン

• 別名: 4-アミノ-N-(アミノイミノメチル)ベンゼンスルホンアミド, 4-アミノ-N-グアニルベンゼンスルホンアミド
• 実験式（ヒル表記法）: C₇H₁₀N₄O₂S
• CAS番号: 57-67-0
• 分子量: 214.24
• Beilstein: 2695326
• EC Number: 200-345-9
• MDL番号: MFCD00038136
• UNSPSCコード: 51283914
• PubChem Substance ID: 24899810
• NACRES: NA.85

特性

• 由来生物: synthetic (Organic)
• 形状: powder
• 色: white to off-white
• 溶解性: 1 M HCl: soluble 50 mg/mL
• 抗生物質活性スペクトル: Gram-negative bacteria; Gram-positive bacteria
• 作用機序: DNA synthesis | interferes; enzyme | inhibits
• SMILES記法: NC(=N)NS(=O)(=O)c1ccc(N)cc1
• InChI: 1S/C7H10N4O2S/c8-5-1-3-6(4-2-5)14(12,13)11-7(9)10/h1-4H,8H2,(H4,9,10,11)
• InChI Key: BRBKOPJOKNSWSG-UHFFFAOYSA-N
• 遺伝子情報: human ... F2(2147) , PRSS1(5644)

詳細

詳細

Chemical structure: sulfonamide

アプリケーション

Sulfaguanidine is used to block the synthesis of folic acid. It is used to study its effect on microsporidial growth and host cell viability.

生物化学的／生理学的作用

Sulfaguanidine is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. Sulfaguanidine is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

その他情報

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves