S1442

ソルダリン ナトリウム塩

from Sordaria araneosa, ≥98% (HPLC), solid

• 実験式（ヒル表記法）: C₂₇H₃₉NaO₈
• CAS番号: 463356-00-5
• 分子量: 514.58
• MDL番号: MFCD08277029
• UNSPSCコード: 51111800
• PubChem Substance ID: 24899480
• NACRES: NA.77

特性

• 由来生物: Sordaria araneosa
• 品質水準: 200
• アッセイ: ≥98% (HPLC)
• 形状: solid
• 溶解性: H₂O: soluble ≤10 mg/mL
• 抗生物質活性スペクトル: fungi
• 作用機序: protein synthesis | interferes
• 輸送温度: wet ice
• 保管温度: −20°C
• SMILES記法: [Na+].[H]C(=O)[C@]12C[C@]3([H])C=C(C(C)C)[C@@]1(C([O-])=O)[C@]3(CO[C@@H]4O[C@H](C)[C@@H](OC)[C@@H](O)[C@@H]4O)C[C@]5([H])[C@H](C)CC[C@@]25[H]
• InChI: 1S/C27H40O8.Na/c1-13(2)19-8-16-9-25(11-28)18-7-6-14(3)17(18)10-26(16,27(19,25)24(31)32)12-34-23-21(30)20(29)22(33-5)15(4)35-23;/h8,11,13-18,20-23,29-30H,6-7,9-10,12H2,1-5H3,(H,31,32);/q;+1/p-1/t14-,15-,16+,17-,18-,20+,21+,22-,23-,25+,26+,27+;/m1./s1
• InChI Key: ILUKWKGTAAZHDW-IGICPMPSSA-M

詳細

アプリケーション

Soradrin sodium salt has been used as an antifungal compound to treat mycelia for immunofluorescence microscopy studies. It may be used in in vitro diphtheria toxin sensitivity assays.

生物化学的／生理学的作用

Sordarin is an antifungal metabolite possessing a tetracyclic diterpene glycoside structure. It is a highly potent inhibitor of eukaryotic protein synthesis with selectivity for the fungal translation machinery. The elongation factor EF-2 is the molecular target for sordarin. It blocks ribosomal translocation by stabilizing the EF2-ribosome complex in a manner similar to that of fusidic acid in the bacterial system. Additional cellular components (including rpP0, which is an essential protein of the ribosomal large subunit stalk) are involved in its mechanism of action. Sordarin inhibits in vitro translation in the pathogenic fungi C. albicans, C. glabrata, and C. neoformans. In addition to its therapeutic potential, sordarin is a useful tool for the analysis of protein translation events.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)