P0099

パリペリドン

≥98% (HPLC)

• 別名: 3-[2-[4-(6-フルオロ-1,2-ベンゾイソオキサゾール-3-イル)-1-ピペリジニル]エチル]-6,7,8,9-テトラヒドロ-9-ヒドロキシ-2-メチル-4H-ピリド[1,2-a]ピリミジン-4-オン
• 実験式（ヒル表記法）: C₂₃H₂₇FN₄O₃
• CAS番号: 144598-75-4
• 分子量: 426.48
• MDL番号: MFCD00871802
• UNSPSCコード: 12352200
• PubChem Substance ID: 329820012
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to brown
• 溶解性: DMSO: 2 mg/mL, clear (warmed)
• オーガナイザー: Johnson & Johnson
• 保管温度: room temp
• SMILES記法: CC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCC(O)C5=N1
• InChI: 1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3
• InChI Key: PMXMIIMHBWHSKN-UHFFFAOYSA-N
• 遺伝子情報: human ... DRD2(1813) , HTR2A(3356)

詳細

アプリケーション

Paliperidone has been used as an atypical antipsychotic drug (AAPD) to study its efficacy in preventing psychopathology of mice prenatally immune challenged with lipopolysaccharide (LPS). It has also been used as an atypical antipsychotic drug (AAPD) to explain the modulation of hypothalamic-pituitary-adrenal (HPA) axis in female mice prenatally treated with bacterial endotoxin lipopolysaccharide (LPS).

生物化学的／生理学的作用

パリペリドンは非定型抗精神病薬であり、リスペリドンの活性代謝産物です。

特徴および利点

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301
• 注意書き: P264 - P270 - P301 + P310 - P405 - P501
• 危険有害性の分類: Acute Tox. 3 Oral
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges