N1413

NSCI

≥97% (HPLC), solid

• 別名: 1-(4-メトキシベンジル)-5-[2-(ピリジン-3-イル-オキシメチル)ピロリジン-1-スルホニル]-1H-インドール-2,3-ジオン
• 実験式（ヒル表記法）: C₂₆H₂₅N₃O₆S
• CAS番号: 872254-32-5
• 分子量: 507.56
• UNSPSCコード: 12352200
• PubChem Substance ID: 24897488
• NACRES: NA.77

特性

• アッセイ: ≥97% (HPLC)
• 形状: solid
• 溶解性: DMSO: >10 mg/mL; H₂O: insoluble
• 保管温度: −20°C
• SMILES記法: COc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N4CCC[C@H]4COc5cccnc5)cc1
• InChI: 1S/C26H25N3O6S/c1-34-20-8-6-18(7-9-20)16-28-24-11-10-22(14-23(24)25(30)26(28)31)36(32,33)29-13-3-4-19(29)17-35-21-5-2-12-27-15-21/h2,5-12,14-15,19H,3-4,13,16-17H2,1H3/t19-/m0/s1
• InChI Key: XDHJBIYJRNFDKS-IBGZPJMESA-N
• 遺伝子情報: human ... CASP1(834) , CASP3(836) , CASP6(839) , CASP7(840) , SUMO1(7341)

詳細

アプリケーション

NSCI has been used as an apoptosis inhibitor to study its effects on caspase 9 activity in cultured tick cells. It has also been used as an apoptosis inhibitor in terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay to study anti-CD3-induced apoptosis in the cluster of differentiation 4 (CD4⁺) and cluster of differentiation 8 (CD8⁺) T cells from pleural effusions, mononuclear cells (PEMCs).

生物化学的／生理学的作用

1-(4-Methoxybenzyl)-5-[2-(pyridin-3-yl-oxymethyl)pyrrolidine-1-sulfonyl]-1H-indole-2,3-dione (NSCI) is a nonpeptide caspase 3 selective inhibitor.

特徴および利点

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable