433R-1

IMP3 (EP286) Rabbit Monoclonal Primary Antibody

• UNSPSCコード: 12352200

特性

• 由来生物: rabbit
• 品質水準: 100; 500
• 結合体: unconjugated
• 抗体製品の状態: culture supernatant
• 抗体製品タイプ: primary antibodies
• クローン: EP286, monoclonal
• 詳細: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• 形状: buffered aqueous solution
• 化学種の反応性: human
• 包装: vial of 0.1 mL concentrate (433R-14); vial of 0.5 mL concentrate (433R-15); bottle of 1.0 mL predilute (433R-17); vial of 1.0 mL concentrate (433R-16); bottle of 7.0 mL predilute (433R-18)
• メーカー／製品名: Cell Marque^™
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
• アイソタイプ: IgG
• コントロール: pancreatic ductal adenocarcinoma, placenta
• 輸送温度: wet ice
• 保管温度: 2-8°C
• 視覚化: cytoplasmic, membranous
• 遺伝子情報: human ... IMP3(55272)

詳細

詳細

Insulin-like growth factor II mRNA binding protein 3 (IMP3) is an oncofetal RNA-binding protein that regulates targets such as insulin-like growth factor-2 and beta-actin. IMP3 expression is at its highest during embryogenesis and silenced in normal human tissues (fibroblasts, lymphocytes, and testes are exceptions).¹ IMP3 plays a major role in early embryogenesis involving the development of the intestine, thymus, pancreas, and kidneys.² IMP3 mRNA transcript and protein have been demonstrated in high levels in pancreatic cancer tissues but not in benign lesions of the pancreas, chronic pancreatitis, or normal pancreatic tissues.¹ In a study of IMP3 being used to distinguish between pancreatic ductal adenocarcinoma from chronic sclerosing pancreatitis, IMP3 was found to have high sensitivity and specificity for pancreatic ductal adenocarcinoma and detected pancreatic ductal adenocarcinoma metastases.² IMP3 expression has also been found in a variety of other human cancers including renal cell carcinoma, adenocarcinoma of the uterine cervix, endometrial carcinoma, adenocarcinoma of the esophagus, malignant melanoma, Merkel cell carcinoma, urothelial carcinoma, neuroendocrine carcinoma of the lung, adenocarcinoma of the pancreas, and triple negative breast cancer.^1,2

品質

IVD

IVD

IVD

RUO

関連事項

IMP3 Positive Control Slides, Product No. 433S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

物理的形状

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

調製ノート

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

その他情報

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法的情報

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany