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由来生物
rat
品質水準
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
MA6, monoclonal
化学種の反応性
mouse
メーカー／製品名
Chemicon®
テクニック
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
アイソタイプ
IgG2κ
適合性
not suitable for Western blot
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... ITGA6(3655)
特異性
Reacts with the laminin receptor alpha-6beta-1 and alpha-6beta-4 complexes.
アプリケーション
Immunoprecipitation, flow cytometry, immunohistochemistry in frozen tissue sections. Product does not detect alpha 6 in Western blot since the epitope most likely involves both alpha 6 and beta 1 integrin subunit. Product does not block alpha 6 integrin mediated cell adhesion to laminin. Activation of integrin signaling properties by MA6 has not been characterized. Immunoprecipitation of VLA-6 from lysate of 10E6 cell equivalent requires 2 μg of MA6. Recommended concentration for flow cytometry - 10 μg/mL, staining of frozen tissue sections - 20 μg/mL.
Optimal working dilutions must be determined by end user.
Cell lines tested by using MA6 to express (6 integrins include: mouse bone marrow-derived mast cells, melanoma cell line B16F1, squamous carcinoma SCC-VII, fibroblast cell line NIH-3T3, splenic T lymphocytes, thymocytes and various T cell lines.
Optimal working dilutions must be determined by end user.
Cell lines tested by using MA6 to express (6 integrins include: mouse bone marrow-derived mast cells, melanoma cell line B16F1, squamous carcinoma SCC-VII, fibroblast cell line NIH-3T3, splenic T lymphocytes, thymocytes and various T cell lines.
This Anti-Integrin α6 Antibody, clone MA6 is validated for use in FC, IP, IH for the detection of Integrin α6.
物理的形状
Format: Purified
Liquid in 0.02M Phosphate buffer, pH 7.6, with 0.25M NaCl and 0.1% sodium azide.
保管および安定性
Store at +2-8°C for up to 12 months.
その他情報
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法的情報
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
MAB1982:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Derivation of a new human embryonic stem cell line, Endeavour-2, and its characterization.
Kuldip S Sidhu,John P Ryan,Justin G Lees,Bernard E Tuch
In Vitro Cellular & Developmental Biology. Animal null
Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3.
de Guzman Strong, C; Wertz, PW; Wang, C; Yang, F; Meltzer, PS; Andl, T; Millar, SE; Ho et al.
The Journal of cell biology null
Dongren Yang et al.
The Journal of cell biology, 168(4), 655-666 (2005-02-09)
Schwann cells form basal laminae (BLs) containing laminin-2 (Ln-2; heterotrimer alpha2beta1gamma1) and Ln-8 (alpha4beta1gamma1). Loss of Ln-2 in humans and mice carrying alpha2-chain mutations prevents developing Schwann cells from fully defasciculating axons, resulting in partial amyelination. The principal pathogenic mechanism
Naomi Walsh et al.
Journal of experimental & clinical cancer research : CR, 28, 140-140 (2009-10-15)
Factors mediating the invasion of pancreatic cancer cells through the extracellular matrix (ECM) are not fully understood. In this study, sub-populations of the human pancreatic cancer cell line, MiaPaCa-2 were established which displayed differences in invasion, adhesion, anoikis, anchorage-independent growth
D M Sherry et al.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 239(4), 278-287 (2001-07-14)
Integrin receptors mediate cell-extracellular matrix interactions and regulate many events, including cell growth, proliferation, and differentiation. Retinal integrins are incompletely understood, although these receptors are potentially important factors in normal retinal function and pathology. Immunocytochemistry was used to localize alpha
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