530050-M

PRIMA-1

A cell-permeable quinuclidinone analog with antitumor properties.

• 別名: PRIMA-1, 2,2-Bis(hydroxymethyl)-1-azabicyclo[2,2,2]octan-3-one, p53 Reactivation and Induction of Massive Apoptosis
• 実験式（ヒル表記法）: C₉H₁₅NO₃
• CAS番号: 5608-24-2
• 分子量: 185.22
• MDL番号: MFCD04974196
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥95% (NMR)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: off-white
• 溶解性: water: 2 mg/mL
• 保管温度: 2-8°C
• InChI: 1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
• InChI Key: RFBVBRVVOPAAFS-UHFFFAOYSA-N

詳細

詳細

A cell-permeable quinuclidinone analog with anti-tumor properties. Induces p53-dependent apoptosis in human tumor cells through restoration of the transcriptional transactivation function to mutant p53. Restores sequence-specific DNA binding and active conformation to mutant p53 proteins in vitro and in living cells. Suppresses tumor growth in mice with no apparent toxicity. Induces apoptosis in breast cancer cells expressing mutant p53.

A cell-permeable quinuclidinone analog with antitumor properties. Restores biochemical and biological function to mutant p53 and induces p53-dependent apoptosis in vitro and in vivo. Induces apoptosis in breast cancer cells expressing mutant p53.

生物化学的／生理学的作用

Primary Target
Restores biochemical and biological function to mutant p53

警告

Toxicity: Standard Handling (A)

その他情報

Bykov, V.J., et al. 2002. Nat. Med.8, 282.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS08,GHS07
• シグナルワード: Danger
• 危険有害性情報: H302,H334
• 注意書き: P261 - P264 - P270 - P284 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral - Resp. Sens. 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable