513100

DL-threo-PDMP, Hydrochloride

PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and acts as a potent and competitive inhibitor of this enzyme.

• 別名: DL-threo-PDMP, Hydrochloride, 1-Phenyl-2-decanoylamino-3-morpholino-1-propanol, HCl
• 実験式（ヒル表記法）: C₂₃H₃₈N₂O₃ · xHCl
• CAS番号: 80938-69-8
• 分子量: 390.56 (free base basis)
• MDL番号: MFCD00236490
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: white
• 溶解性: DMSO: soluble; ethanol: soluble; methanol: soluble
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C23H38N2O3.ClH/c1-2-3-4-5-6-7-11-14-22(26)24-21(19-25-15-17-28-18-16-25)23(27)20-12-9-8-10-13-20;/h8-10,12-13,21,23,27H,2-7,11,14-19H2,1H3,(H,24,26);1H/t21-,23-;/m1./s1
• InChI Key: HVJHJOYQTSEKPK-BLDCTAJRSA-N

詳細

詳細

PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and acts as a potent and competitive inhibitor of this enzyme. Blocks the outgrowth of neurites and inhibits glycolipid synthesis in cultured NIH/3T3 cells.

PDMP closely resembles the natural sphingolipid substrate of brain glucosyltransferase and is a potent and competitive inhibitor of this enzyme. Blocks the outgrowth of neurites and inhibits glycolipid synthesis in cultured 3T3 cells.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
glycolipid synthesis in cultured NIH/3T3 cells

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Irritant (B)

その他情報

Rani, C.S., et al. 1995. J. Biol. Chem. 270, 2859.
Rosenwald, A.G. 1992. Biochemistry31, 3581.
Inokuchi, J., and Radin, N.S. 1987. J. Lipid Res.28, 565.
Vunnam, R.R., and Radin, N.S. 1980. Chem. Phys. Lipids26, 265.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable