445800

Merbarone

≥95% (HPLC), solid, topoisomerase II inhibitor, Calbiochem^®

• 別名: Merbarone, 5-(N-Phenylcarboxamido)-2-thiobarbituric Acid, NSC-336628
• 実験式（ヒル表記法）: C₁₁H₉N₃O₃S
• CAS番号: 97534-21-9
• 分子量: 263.27
• MDL番号: MFCD00866337
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• product name: Merbarone, A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes.
• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: faint pink
• 溶解性: DMSO: 100 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5H,(H,12,15)(H3,13,14,16,17,18)
• InChI Key: GFYRZTLCYQQVHZ-UHFFFAOYSA-N

詳細

詳細

A cell-permeable anticancer drug that inhibits the catalytic activity of topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC₅₀ = 20 µM for purified mammalian topo II versus IC₅₀ = ~ 200 µM for topo I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.

A cell-permeable, anticancer drug that inhibits the catalytic activity of DNA topoisomerase II (topo II) without damaging DNA or stabilizing DNA-topo II cleavable complexes (IC₅₀ = 20 µM for purified mammalian topoisomerase II versus IC₅₀ ~200 µM for topoisomerase I). Also induces apoptosis in human leukemic CEM cells through a caspase-3-like protease-dependent mechanism.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
Catalytic activity of topoisomerase II

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 20 µM for purified topoisomerase II (topo II)

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

その他情報

Khelifa, T., and Beck, W.T. 1999. Mol. Pharmacol. 55, 548.
Drake, F.H., et al. 1989. Cancer Res.49, 2578.
Brewer, A.D., et al. 1985. Biochem. Pharmacol.34, 2047.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable