407601

Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor

The Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor controls the activity of Interleukin-1 Receptor-Associated-Kinase-1/4. Primarily used for Phosphorylation & Dephosphorylation apps.

• 別名: Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor, IRAK-1/4 Inhibitor, N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole
• 実験式（ヒル表記法）: C₂₀H₂₁N₅O₄
• CAS番号: 509093-47-4
• 分子量: 395.41
• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: crystalline solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: yellow
• 溶解性: DMSO: 10 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C20H21N5O4/c26-19(15-4-3-5-16(14-15)25(27)28)22-20-21-17-6-1-2-7-18(17)24(20)9-8-23-10-12-29-13-11-23/h1-7,14H,8-13H2,(H,21,22,26)
• InChI Key: QTCFYQHZJIIHBS-UHFFFAOYSA-N

詳細

詳細

A cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC₅₀ = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC₅₀ >10 µM), including lck and src.

A cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC₅₀ = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC₅₀ >10 µM), including lck and src. Also available as a 25 mM solution in DMSO (Cat. No. 407602).

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
Interleukin-1 receptor-associated kinases

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 300 nM and 200 nM for IRAK-1 and -4

包装

Packaged under inert gas

警告

Toxicity: Harmful (C)

その他情報

Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol.293, G429.
Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett.16, 2842.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3