345701

Gambogic Acid, Garcinia hanburyi

A cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties.

• 別名: Gambogic Acid, Garcinia hanburyi, Guttic Acid, β-Guttiferin
• 実験式（ヒル表記法）: C₃₈H₄₄O₈
• CAS番号: 2752-65-0
• 分子量: 628.75
• UNSPSCコード: 12352106
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (TLC)
• 形状: amorphous solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: orange
• 溶解性: DMSO: 10 mg/mL; ethanol: soluble
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23?,27?,36-,37?,38-/m1/s1
• InChI Key: GEZHEQNLKAOMCA-PLUQQRNKSA-N

詳細

詳細

A cell-permeable caspase activator and an apoptosis inducer that was originally isolated from gamboge resin for its antimicrobial properties. Shown to inhibit the growth of HeLa and HEL cells minimal inhibitory concentrations (MIC = 12.5 µg/ml).

A cell-permeable, anti-microbial xanthone orignally isolated from the gamboge resin of Garcinia hanburyi. Acts as a caspase activator and apoptosis inducer. Shown to inhibit the growth of HeLa and HEL cells (MIC = 12.5 µg/ml). Reported to block telomerase activity in SMMC-7721 cells. Shown to induce tyrosine kinase phosphatase SHP-1 and suppress Stat3 activation.

生物化学的／生理学的作用

Cell permeable: yes

MIC = 12.5 µg/ml in inhibiting the growth of HeLa and HEL cells

Primary Target
Caspase activator and an apoptosis inducer

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

警告

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

その他情報

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Prasad, S., et al. 2011. Cancer Prev. Res.4, 1084.
Guo, Q.L., et al. 2004. Acta Pharmacol. Sin.25, 769.
Asano, J., et al. 1996. Phytochemistry41, 815.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301,H315,H319,H335
• 注意書き: P261 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable