124014

Akt Inhibitor VII, TAT-Akt-in

The Akt Inhibitor VII, TAT-Akt-in controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 別名: Akt Inhibitor VII, TAT-Akt-in, H- YGRKKRRQRRR-AVTDHPDRLWAWEKF-OH, TAT-TCL1₁₀₋₂₄, H-YGRKKRRQRRR-AVTDHPDRLWAWEKF-OH, TAT-TCL1₁₀₋₂₄
• 実験式（ヒル表記法）: C₁₅₂H₂₃₉N₅₅O₃₆
• 分子量: 3412.87
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: white
• 溶解性: water: 1 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C

詳細

詳細

A cell-permeable and reversible version of the Akt Inhibitor VI, Akt-in (Cat. No. 124013) fused with the protein transduction domain TAT that displays antitumor properties. Inhibits the phosphorylation of Akt selectively in HEK 293 and QRsP-11 fibrosarcoma cells stimulated with PDGF (complete inhibition at ~50 µM) with minimal inhibition towards PKA, PKC, PDK1, p42/44 MAPK, or p38 MAPK. Shown to prevent the proliferation of T4 cells, and tumor growth in syngeneic C57BL/6 mice.

A cell-permeable and reversible version of the Akt Inhibitor VI, Akt-in (Cat. No. 124013) fused with the protein transduction domain TAT. Selectively inhibits the phosphorylation of Akt selectively in HEK 293 and QRsP-11 fibrosarcoma cells stimulated with PDGF (complete inhibition at ~50 µM) with minimal inhibition towards PKA, PKC, PDK1, p42/44 MAPK, or p38 MAPK. Shown to prevent the proliferation of T4 cells and tumor growth in syngeneic C57BL/6 mice at 2 µM/mouse without any adverse effect.

生物化学的／生理学的作用

Cell permeable: yes

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 50 µM against Akt

包装

Packaged under inert gas

警告

Toxicity: Carcinogenic / Teratogenic (D)

シーケンス

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable