800817C

18:0-18:2 DG

1-stearoyl-2-linoleoyl-sn-glycerol, chloroform

• 別名: 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycerol; DG(18:0/18:2(9Z,12Z)/0:0)
• 実験式（ヒル表記法）: C₃₉H₇₂O₅
• CAS番号: 34487-26-8
• 分子量: 620.99
• UNSPSCコード: 12352211
• NACRES: NA.25

特性

• アッセイ: >99% (TLC)
• 形状: liquid
• 包装: pkg of 1 × 5 mL (800817C-10mg)
• メーカー／製品名: Avanti Research^™ - A Croda Brand 800817C
• 濃度: 2 mg/mL (800817C-10mg)
• 脂質タイプ: neutral lipids; neutral glycerides
• 輸送温度: dry ice
• 保管温度: −20°C
• InChI: 1S/C39H72O5/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(41)43-36-37(35-40)44-39(42)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h12,14,18,20,37,40H,3-11,13,15-17,19,21-36H2,1-2H3/b14-12-,20-18-/t37-/m0/s1
• InChI Key: AJMZUFBKADIAKC-SKTOPKGQSA-N

詳細

詳細

18:0-18:2 DG (diacylglycerol) is a second messenger signaling lipid in biochemical signaling and is a product of the hydrolysis of the phospholipid PIP2 (phosphatidylinositolbisphosphate) by the enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). It possess hydrophobic properties due to which it remains within the plasma membrane.

生物化学的／生理学的作用

DAG plays a vital role in the physiological activation of protein kinase C (PKC). The production of DAG in the membrane facilitates translocation of PKC from the cytosol to the plasma membrane. Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters.

包装

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800817C-10mg)

保管および安定性

Diacylglycerols are conveniently stored in chloroform solutions in glass vials with PTFE-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.

その他情報

Delivery to cells:
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.

Effective concentration:
Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.

Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.

法的情報

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全性情報

• ピクトグラム: GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H302,H315,H319,H331,H336,H351,H361d,H372,H412
• 注意書き: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• 危険有害性の分類: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• ターゲットの組織: Central nervous system, Liver,Kidney
• WGK: WGK 3