RPE65
retinal pigment epithelium-specific protein 65kDa
別名:
LCA2, RP20, mRPE65, rd12, sRPE65
Species:
Human RPE65 (6121), Mouse Rpe65 (19892), Rat Rpe65 (89826), cow RPE65 (282043), sheep RPE65 (101116520), domestic guinea pig Rpe65 (100721944), naked mole-rat Rpe65 (101716560), Domestic Rabbit RPE65 (100352270), chicken RPE65 (395700), domestic cat RPE65 (101090034)
UniProtKB ID:
遺伝子ID:
- Human(6121) Summary: This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa. [provided by RefSeq, Jul 2008]
- Mouse(19892) retinal pigment epithelium 65
- Rat(89826) retinal pigment epithelium 65
- cow(282043) retinal pigment epithelium-specific protein 65kDa
- sheep(101116520) retinal pigment epithelium-specific protein 65kDa
- domestic guinea pig(100721944) retinal pigment epithelium-specific protein 65kDa
- naked mole-rat(101716560) retinal pigment epithelium-specific protein 65kDa
- Domestic Rabbit(100352270) retinal pigment epithelium-specific protein 65kDa
- chicken(395700) retinal pigment epithelium-specific protein 65kDa
- domestic cat(101090034) retinal pigment epithelium-specific protein 65kDa
- dog(403803) retinal pigment epithelium-specific protein 65kDa
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Antibodies
Product Number
詳細
交差性
アプリケーション
抗網膜色素上皮65抗体, clone 401.8B11.3D9, Chemicon®, from mouse,
交差性
xenopus, bovine, human, mouse
アプリケーション
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-RPE65 Antibody, clone 2F8 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
交差性
human, mouse, rabbit
アプリケーション
affinity binding assay
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-RPE65 Antibody, clone 401.8B11.3D9 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
交差性
xenopus, bovine, canine, human, monkey, mouse, porcine, rat
アプリケーション
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
抗RPE65抗体 ヤギ宿主抗体, affinity isolated antibody, buffered aqueous solution,
交差性
canine, human
アプリケーション
ELISA
western blot
western blot
Anti-RPA70 antibody produced in rabbit, ,
交差性
human, mouse
アプリケーション
immunohistochemistry
western blot
western blot