NCF4
neutrophil cytosolic factor 4, 40kDa
別名:
NCF, P40PHOX, SH3PXD4
Species:
Human NCF4 (4689), Mouse Ncf4 (17972), Rat Ncf4 (500904), sheep NCF4 (101122939), naked mole-rat Ncf4 (101699188), Domestic Rabbit NCF4 (100009359), domestic guinea pig Ncf4 (100729267), Zebrafish ncf4 (403014), chicken NCF4 (418052), domestic cat NCF4 (101095507) ...詳細
UniProtKB ID:
遺伝子ID:
- Human(4689) Summary: The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
- Mouse(17972) neutrophil cytosolic factor 4
- Rat(500904) neutrophil cytosolic factor 4
- sheep(101122939) neutrophil cytosolic factor 4, 40kDa
- naked mole-rat(101699188) neutrophil cytosolic factor 4, 40kDa
- Domestic Rabbit(100009359) neutrophil cytosolic factor 4, 40kDa
- domestic guinea pig(100729267) neutrophil cytosolic factor 4, 40kDa
- Zebrafish(403014) neutrophil cytosolic factor 4
- chicken(418052) neutrophil cytosolic factor 4, 40kDa
- domestic cat(101095507) neutrophil cytosolic factor 4, 40kDa
- cow(507859) neutrophil cytosolic factor 4, 40kDa
- Horse(100069566) neutrophil cytosolic factor 4, 40kDa
- dog(481277) neutrophil cytosolic factor 4, 40kDa
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Antibodies
製品番号
詳細
交差性
アプリケーション
抗NCF4抗体 ウサギ宿主抗体, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunohistochemistry
抗NCF4抗体 ウサギ宿主抗体, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
交差性
human
アプリケーション
immunofluorescence
抗NCF4抗体 ウサギ宿主抗体, affinity isolated antibody,
交差性
guinea pig, horse, human, rat
アプリケーション
western blot
抗NCF4抗体 マウス宿主抗体, purified immunoglobulin, buffered aqueous solution,
交差性
human
アプリケーション
western blot
Anti-NCF4/p40-phox Antibody, clone 4L9Z4, Rabbit Monoclonal, ,
交差性
mouse
アプリケーション
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Proteins
製品番号
詳細
Species