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Merck

HSD11B2

hydroxysteroid (11-beta) dehydrogenase 2

別名:
AME, AME1, HSD11K, HSD2, SDR9C3
Species:
UniProtKB ID:
遺伝子ID:
  • Human(3291) Summary: There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
  • Mouse(15484) hydroxysteroid 11-beta dehydrogenase 2
  • Rat(25117) hydroxysteroid 11-beta dehydrogenase 2
  • Zebrafish(334098) hydroxysteroid 11-beta dehydrogenase 2
  • cow(282434) hydroxysteroid (11-beta) dehydrogenase 2
  • Horse(100034124) hydroxysteroid (11-beta) dehydrogenase 2
  • domestic cat(100529249) hydroxysteroid (11-beta) dehydrogenase 2
  • dog(489758) hydroxysteroid (11-beta) dehydrogenase 2
  • chicken(100857283) hydroxysteroid (11-beta) dehydrogenase 2
  • Domestic Rabbit(100009531) hydroxysteroid (11-beta) dehydrogenase 2
  • domestic guinea pig(100733422) hydroxysteroid (11-beta) dehydrogenase 2
  • naked mole-rat(101712460) hydroxysteroid (11-beta) dehydrogenase 2

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Antibodies

製品番号
詳細
交差性
アプリケーション
抗HSD11B2抗体 ウサギ宿主抗体, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunofluorescence
immunohistochemistry
抗HSD11B2抗体 ウサギ宿主抗体, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunohistochemistry
western blot
Anti-HSD11B2 antibody produced in rabbit, affinity isolated antibody,
交差性
bovine, guinea pig, human, mouse, rabbit, rat, sheep
アプリケーション
western blot
抗HSD11B2抗体 マウス宿主抗体, purified immunoglobulin, buffered aqueous solution,
交差性
human
アプリケーション
western blot

Small Molecule - Inhibitor

製品番号
詳細
Species
18β-グリチルレチン酸, 97%,
Species
rat, human

esiRNA

製品番号
詳細
Species
MISSION® esiRNA, targeting human HSD11B2,
Species
human