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Design and synthesis of sulfonamide derivatives of pyrrolidine and piperidine as anti-diabetic agents.

Design and synthesis of sulfonamide derivatives of pyrrolidine and piperidine as anti-diabetic agents.

European journal of medicinal chemistry (2014-12-02)

Radhika Sharma, Shubhangi S Soman

ABSTRACT

Type 2 diabetes (T2D) is a lifestyle disease affecting millions of people worldwide. Various therapies are available for the management of T2D and dipeptidyl peptidase-IV (DPP-IV) inhibition has emerged as a promising therapy for the treatment of type 2 diabetes (T2D). Here we report design, synthesis and in vitro efficacy of sulfonamide derivatives of pyrrolidine and piperidine as anti-diabetic agents. Amongst all the compounds synthesized in this series, 9a, is the most potent (IC50 = 41.17 nM).

MATERIALS

Product Number

Brand

Product Description

154903

Sigma-Aldrich

Methanol, ACS spectrophotometric grade, ≥99.9%

221864

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Potassium bromide, FT-IR grade, ≥99% trace metals basis

243418

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Potassium bromide, ACS reagent, ≥99.0%

24229

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Methanol, puriss., meets analytical specification of Ph Eur, ≥99.7% (GC)

494437

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Methanol, BioReagent, ≥99.93%

239313

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Sodium sulfate, ACS reagent, ≥99.0%, anhydrous, granular

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774243

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Sodium sulfate, anhydrous, free-flowing, Redi-Dri^™, ACS reagent, ≥99%

M1775

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Methanol, Absolute - Acetone free

P9881

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Potassium bromide, ReagentPlus^®, ≥99.0%

S9627

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Sodium sulfate, ReagentPlus^®, ≥99.0%

676780

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13464

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Sodium sulfate, puriss., meets analytical specification of Ph. Eur., BP, USP, anhydrous, 99.0-100.5% (calc. to the dried substance)

746444

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34885

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Methanol, suitable for HPLC, gradient grade, ≥99.9%

34860

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Methanol, suitable for HPLC, ≥99.9%

439193

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31481

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238597

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32213

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Methanol, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.8% (GC)

320390

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793531

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