Merck
  • Home
  • Search Results
  • Hippocampal neuroligin-2 links early-life stress with impaired social recognition and increased aggression in adult mice.

Hippocampal neuroligin-2 links early-life stress with impaired social recognition and increased aggression in adult mice.

Psychoneuroendocrinology (2015-03-15)
Christine Kohl, Xiao-Dong Wang, Jocelyn Grosse, Céline Fournier, Daniela Harbich, Sören Westerholz, Ji-Tao Li, Alexandre Bacq, Claudia Sippel, Felix Hausch, Carmen Sandi, Mathias V Schmidt
ABSTRACT

Early-life stress is a key risk factor for the development of neuropsychiatric disorders later in life. Neuronal cell adhesion molecules have been strongly implicated in the pathophysiology of psychiatric disorders and in modulating social behaviors associated with these diseases. Neuroligin-2 is a synaptic cell adhesion molecule, located at the postsynaptic membrane of inhibitory GABAergic synapses, and is involved in synaptic stabilization and maturation. Alterations in neuroligin-2 expression have previously been associated with changes in social behavior linked to psychiatric disorders, including schizophrenia and autism. In this study, we show that early-life stress, induced by limited nesting and bedding material, leads to impaired social recognition and increased aggression in adult mice, accompanied by increased expression levels of hippocampal neuroligin-2. Viral overexpression of hippocampal neuroligin-2 in adulthood mimics early-life stress-induced alterations in social behavior and social cognition. Moreover, viral knockdown of neuroligin-2 in the adult hippocampus attenuates the early-life stress-induced behavioral changes. Our results highlight the importance of neuroligin-2 in mediating early-life stress effects on social behavior and social cognition and its promising role as a novel therapeutic target for neuropsychiatric disorders.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
DAPI, for nucleic acid staining
Sigma-Aldrich
Acetaminophen, BioXtra, ≥99.0%
Sigma-Aldrich
Acetaminophen, meets USP testing specifications, 98.0-102.0%, powder
Sigma-Aldrich
Acetaminophen, analytical standard
Sigma-Aldrich
β-D-Allose, rare aldohexose sugar
Supelco
Acetaminophen, Pharmaceutical Secondary Standard; Certified Reference Material
Supelco
Acetaminophen solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
USP
Acetaminophen, United States Pharmacopeia (USP) Reference Standard
Supelco
Corticosterone, VETRANAL®, analytical standard
Sigma-Aldrich
Corticosterone, ≥98.5% (HPLC)
Sigma-Aldrich
Corticosterone, ≥92%
Paracetamol, European Pharmacopoeia (EP) Reference Standard