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  • Hydrogel-gauze dressing for moderate-to-severe atopic dermatitis: development and efficacy study on atopic dermatitis-like skin lesions in NC/Nga mice.

Hydrogel-gauze dressing for moderate-to-severe atopic dermatitis: development and efficacy study on atopic dermatitis-like skin lesions in NC/Nga mice.

Drug development and industrial pharmacy (2013-09-13)
Shiow-Fern Ng, Pit-Chin Lew, Yong-Boey Sin
ABSTRACT

Topical emollients are known to provide symptomatic relief for atopic dermatitis. In hospitals, wet-wrap therapy has been shown to benefit children with moderate-to-severe atopic dermatitis (AD), but the application of wet-wraps is tedious and time-consuming. Topical emollients have low residence time and often dry out easily. The aim of this work was to develop a hydrogel-gauze dressing that is not only easy to apply but also rehydrates and traps moisture to provide longer relief for AD patients. In this study, a prototype hydrogel-gauze dressing was developed with varying ratios of sodium carboxymethylcellulose (NaCMC) and propylene glycol. The hydrogel-gauze dressings were assessed based on the moisture vapor transmission rate, moisture absorption, mechanical properties and storage stability over three months. Then, the efficacy of the hydrogel-gauze dressing was compared to topical emollients using transgenic NC/Nga mice with AD-like lesions. The NaCMC hydrogel-gauze dressings significantly lowered transepidermal water loss, and the animals displayed a faster recovery, which indicates that hydrogel-gauze dressings can trap moisture more effectively and accelerate AD healing. Hence, we propose that hydrogel-gauze dressings can potentially become an alternative to wet-wrap therapy due to the ease of application and the higher efficacy compared to topical products.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Acetone, histological grade, ≥99.5%
Sigma-Aldrich
Diethyl ether, anhydrous, ACS reagent, ≥99.0%, contains BHT as inhibitor
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Diethyl ether, reagent grade, ≥98%, contains ≤2% ethanol and ≤10ppm BHT as inhibitor
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Acetone, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.5% (GC)
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Diethyl ether, puriss., contains ~5 mg/L 2,6-di-tert.-butyl-4-methylphenol as stabilizer, meets analytical specification of Ph. Eur., BP, ≥99.5% (GC)
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Diethyl ether, ACS reagent, anhydrous, ≥99.0%, contains BHT as inhibitor
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Diethyl ether, suitable for HPLC, ≥99.9%, inhibitor-free
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Acetone, suitable for HPLC, ≥99.9%
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Acetone, suitable for HPLC, ≥99.8%
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Acetone, HPLC Plus, for HPLC, GC, and residue analysis, ≥99.9%
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Acetone, ACS reagent, ≥99.5%
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Acetone, puriss., meets analytical specification of Ph. Eur., BP, NF, ≥99% (GC)
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Diethyl ether, contains BHT as inhibitor, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.8%
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Potassium chloride, anhydrous, free-flowing, Redi-Dri, ACS reagent, ≥99%
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Acetone, ACS reagent, ≥99.5%
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Potassium chloride, puriss. p.a., ≥99.5% (AT)
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Potassium chloride, puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E508, 99-100.5% (AT), ≤0.0001% Al
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Acetone, Laboratory Reagent, ≥99.5%
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Diethyl ether, ACS reagent, ≥98.0%, contains ≤2% ethanol and ≤10ppm BHT as inhibitor
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Potassium chloride, ACS reagent, 99.0-100.5%
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Potassium chloride, anhydrous, free-flowing, Redi-Dri, ReagentPlus®, ≥99%
SAFC
Formaldehyde solution, contains 10-15% methanol as stabilizer, 37 wt. % in H2O
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Propylene glycol, FCC, FG
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Acetone, ≥99%, meets FCC analytical specifications
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Diethyl ether, contains 1 ppm BHT as inhibitor, anhydrous, ≥99.7%