Merck

Propylene glycol-induced proximal renal tubular cell injury.

American journal of kidney diseases : the official journal of the National Kidney Foundation (1997-07-01)
P D Yorgin, A A Theodorou, A Al-Uzri, K Davenport, L V Boyer-Hassen, M I Johnson
ABSTRACT

Propylene glycol is a solvent that is used in many oral, injectable, and topical medications. Although uncommon, acute renal failure has been attributed to propylene glycol. The mechanism of propylene glycol-mediated renal injury is unknown. We report a case of acute renal failure in a 16-year-old boy given large doses of pentobarbital and phenobarbital, both of which are solubilized with propylene glycol. A renal biopsy showed proximal renal tubular cell swelling and vacuole formation. The data from this case suggest that the reversible acute renal failure caused by propylene glycol is attributable to proximal renal tubular cell injury.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
1,2-Propanediol, SAJ special grade, ≥99.0%
Sigma-Aldrich
1,2-Propanediol, SAJ first grade, ≥99.0%
Sigma-Aldrich
1,2-Propanediol, ACS reagent, ≥99.5%
Sigma-Aldrich
1,2-Propanediol, ReagentPlus®, 99%
Sigma-Aldrich
1,2-Propanediol, meets analytical specification of Ph. Eur., BP, USP, ≥99.5%
Sigma-Aldrich
1,2-Propanediol, puriss. p.a., ACS reagent, ≥99.5% (GC)
Sigma-Aldrich
1,2-Propanediol, tested according to Ph. Eur.
Supelco
1,2-Propanediol, analytical standard
Sigma-Aldrich
1,2-Propanediol, LR, ≥99%
Sigma-Aldrich
Propylene glycol, FCC, FG
Sigma-Aldrich
Propylene Glycol, meets USP testing specifications
Supelco
Propylene glycol, Pharmaceutical Secondary Standard; Certified Reference Material
USP
Propylene glycol, United States Pharmacopeia (USP) Reference Standard
Propylene glycol, European Pharmacopoeia (EP) Reference Standard