Merck
  • Home
  • Search Results
  • Social disadvantage, genetic sensitivity, and children's telomere length.

Social disadvantage, genetic sensitivity, and children's telomere length.

Proceedings of the National Academy of Sciences of the United States of America (2014-04-09)
Colter Mitchell, John Hobcraft, Sara S McLanahan, Susan Rutherford Siegel, Arthur Berg, Jeanne Brooks-Gunn, Irwin Garfinkel, Daniel Notterman
ABSTRACT

Disadvantaged social environments are associated with adverse health outcomes. This has been attributed, in part, to chronic stress. Telomere length (TL) has been used as a biomarker of chronic stress: TL is shorter in adults in a variety of contexts, including disadvantaged social standing and depression. We use data from 40, 9-y-old boys participating in the Fragile Families and Child Wellbeing Study to extend this observation to African American children. We report that exposure to disadvantaged environments is associated with reduced TL by age 9 y. We document significant associations between low income, low maternal education, unstable family structure, and harsh parenting and TL. These effects were moderated by genetic variants in serotonergic and dopaminergic pathways. Consistent with the differential susceptibility hypothesis, subjects with the highest genetic sensitivity scores had the shortest TL when exposed to disadvantaged social environments and the longest TL when exposed to advantaged environments.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Dopamine hydrochloride
Supelco
Dopamine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
Dopamine hydrochloride, European Pharmacopoeia (EP) Reference Standard
Supelco
Dopamine hydrochloride solution, 1.0 mg/mL in methanol with 5% 1 M HCl (as free base), ampule of 1 mL, certified reference material, Cerilliant®