- Determination of oenothein B as the active 5-alpha-reductase-inhibiting principle of the folk medicine Epilobium parviflorum.
Determination of oenothein B as the active 5-alpha-reductase-inhibiting principle of the folk medicine Epilobium parviflorum.
Journal of natural products (1996-05-01)
D Lesuisse, J Berjonneau, C Ciot, P Devaux, B Doucet, J F Gourvest, B Khemis, C Lang, R Legrand, M Lowinski, P Maquin, A Parent, B Schoot, G Teutsch
PMID8778238
ABSTRACT
Several extracts from Epilobium parviflorum, a plant used in Central Europe for the treatment of prostate disorders, were evaluated in a biochemical assay with 5-alpha-reductase. The aqueous extract displaying inhibition of the enzyme was analyzed, the fraction responsible for this activity was purified, and the active compound identified as a macrocyclic tannin, oenothein B (1).
MATERIALS