Merck
  • Home
  • Search Results
  • Safety assessment of propylene glycol, tripropylene glycol, and PPGs as used in cosmetics.

Safety assessment of propylene glycol, tripropylene glycol, and PPGs as used in cosmetics.

International journal of toxicology (2012-10-25)
Monice M Fiume, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen
ABSTRACT

Propylene glycol is an aliphatic alcohol that functions as a skin conditioning agent, viscosity decreasing agent, solvent, and fragrance ingredient in cosmetics. Tripropylene glycol functions as a humectant, antioxidant, and emulsion stabilizer. Polypropylene glycols (PPGs), including PPG-3, PPG-7, PPG-9, PPG-12, PPG-13, PPG-15, PPG-16, PPG-17, PPG-20, PPG-26, PPG-30, PPG-33, PPG-34, PPG-51, PPG-52, and PPG-69, function primarily as skin conditioning agents, with some solvent use. The majority of the safety and toxicity information presented is for propylene glycol (PG). Propylene glycol is generally nontoxic and is noncarcinogenic. Clinical studies demonstrated an absence of dermal sensitization at use concentrations, although concerns about irritation remained. The CIR Expert Panel determined that the available information support the safety of tripropylene glycol as well as all the PPGs. The Expert Panel concluded that PG, tripropylene glycol, and PPGs ≥3 are safe as used in cosmetic formulations when formulated to be nonirritating.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
1,2-Propanediol, SAJ special grade, ≥99.0%
Sigma-Aldrich
1,2-Propanediol, SAJ first grade, ≥99.0%
Sigma-Aldrich
(S)-(+)-1,2-Propanediol, 96%
Sigma-Aldrich
1,2-Propanediol, ACS reagent, ≥99.5%
Sigma-Aldrich
1,2-Propanediol, ReagentPlus®, 99%
Sigma-Aldrich
1,2-Propanediol, meets analytical specification of Ph. Eur., BP, USP, ≥99.5%
Sigma-Aldrich
1,2-Propanediol, puriss. p.a., ACS reagent, ≥99.5% (GC)
Sigma-Aldrich
1,2-Propanediol, tested according to Ph. Eur.
Supelco
1,2-Propanediol, analytical standard
Sigma-Aldrich
1,2-Propanediol, LR, ≥99%
Sigma-Aldrich
Poly(propylene glycol), average Mn ~425
Sigma-Aldrich
(R)-(−)-1,2-Propanediol, 96%
Sigma-Aldrich
Propylene glycol, FCC, FG
Sigma-Aldrich
Poly(propylene glycol), average Mn ~4,000
Sigma-Aldrich
Poly(propylene glycol), average Mn ~1,000
Sigma-Aldrich
Poly(propylene glycol), average Mn ~2,000
Sigma-Aldrich
Poly(propylene glycol), average Mn ~725
Sigma-Aldrich
Poly(propylene glycol), average Mn ~2,700
Sigma-Aldrich
Polypropylene glycol, P 2,000
Sigma-Aldrich
Polypropylene glycol, P 400
Sigma-Aldrich
Poly(propylene glycol), CP, average Mw 1000
Sigma-Aldrich
Poly(propylene glycol), CP, average Mw 400
Supelco
Propylene glycol, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Propylene Glycol, meets USP testing specifications
USP
Propylene glycol, United States Pharmacopeia (USP) Reference Standard
Propylene glycol, European Pharmacopoeia (EP) Reference Standard