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Reduction of aryl acids by white-rot fungi for the biocatalytic production of aryl aldehydes and alcohols.

Applied microbiology and biotechnology (2000-01-05)
A Hage, H E Schoemaker, J A Field
ABSTRACT

Ligninolytic basidiomycetes were screened for their ability to reduce aryl acids to the corresponding aldehydes and alcohols. Seven fungal strains converted p-anisic acid in high molar yields to the reduced products. The white-rot fungus Bjerkandera sp. strain BOS55 was one of the best reducing strains and was highly tolerant towards high concentrations of different aromatic acids. It was tested for the reduction of p-anisic, veratric, 3-chloro-4-methoxybenzoic, 3,5-dichloro-4-methoxybenzoic, 3,4-dichlorobenzoic, 4-fluorobenzoic, and 3-nitrobenzoic acids. All of these compounds were reduced to their corresponding aldehydes and alcohols.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
p-Anisic acid, ≥99%, FG
Supelco
Melting point standard 182-184°C, analytical standard
Sigma-Aldrich
p-Anisic acid, natural, 99%, FG
Sigma-Aldrich
4-Methoxybenzoic acid, ReagentPlus®, 99%