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Steven A Zdravkovic
Journal of pharmaceutical and biomedical analysis, 112, 126-138 (2015-05-16)
An extractable survey is one of several studies performed on a pharmaceutical storage/delivery system as part of the process of demonstrating that the system is suitable for its intended use. In this paper, a solid phase extraction method for the
Zhicheng Jin et al.
The Journal of biological chemistry, 290(30), 18671-18677 (2015-06-14)
We investigated the compartmentation of the catabolism of dodecanedioate (DODA), azelate, and glutarate in perfused rat livers, using a combination of metabolomics and mass isotopomer analyses. Livers were perfused with recirculating or nonrecirculating buffer containing one fully (13)C-labeled dicarboxylate. Information
C Flavia Massaro et al.
Journal of agricultural and food chemistry, 62(50), 12209-12217 (2014-11-26)
Australian stingless bee honeys have been shown to exert antioxidant and in vitro antimicrobial properties; however their bioactive factors remained unidentified. This study investigated the antibacterial properties of phenolic extracts from Tetragonula carbonaria honeys. Honeys were harvested from beehives in
Simona Pichini et al.
Journal of pharmaceutical and biomedical analysis, 104, 62-66 (2014-12-08)
A pilot study of market surveillance in Senegal has been performed analyzing best selling drugs from an official pharmacy and a street market in two principal cities of Senegal and some traditional preparations from herbal medicine from the same market.
Alexandr N Simonov et al.
PloS one, 10(11), e0141252-e0141252 (2015-11-21)
Cytochrome P450c17 (P450 17A1, CYP17A1) is a critical enzyme in the synthesis of androgens and is now a target enzyme for the treatment of prostate cancer. Cytochrome P450c17 can exhibit either one or two physiological enzymatic activities differentially regulated by
Bernhard Watzer et al.
International journal of legal medicine, 129(4), 759-769 (2014-12-20)
Arthrotec(®) (AT) is a combination of diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), and misoprostol (MP), a synthetic analogue of prostaglandin E1 (PGE1). MP is a lipophilic methyl ester prodrug. It is readily metabolized to the biologically active misoprostol acid (MPA).
Roksana Wierzbicka et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1000, 120-129 (2015-07-29)
High throughput GC-MS methods for quantification of alkylresorcinols (AR), biomarkers of whole grain wheat and rye intake, in plasma and adipose tissue and their metabolites in urine were developed and optimised. Alkylresorcinols in plasma (200μL) and adipose tissues (10-50mg) were
Bin Huang et al.
Environmental science and pollution research international, 21(22), 12898-12908 (2014-07-01)
The occurrence and behavior of endocrine disrupting chemicals (EDCs) in sewage treatment plants (STPs), especially estrogens and phenols, have been closely concerned in previous studies. However, the systematical researches about progestogens and androgens were scarce in STPs adopting different treatment
Johanna Rudbäck et al.
Contact dermatitis, 70(6), 329-339 (2014-03-29)
Citronellol is a frequently used fragrance compound in consumer products. It is present in fragrance mix II, which is used for screening of contact allergy to fragrances. Because of its chemical structure, citronellol could be susceptible to autoxidation. To compare
G Paulsen et al.
The Journal of physiology, 592(24), 5391-5408 (2014-11-12)
This study investigated the effects of vitamin C and E supplementation on acute responses and adaptations to strength training. Thirty-two recreationally strength-trained men and women were randomly allocated to receive a vitamin C and E supplement (1000 mg day(-1) and
Minghua Nie et al.
The Science of the total environment, 487, 785-791 (2013-12-25)
The occurrence and multi-phase distribution of six environmental estrogen compounds were investigated in a drinking water reservoir area by analyzing estrogens in suspended particulate matter (SPM), filtrate (conventional dissolved phase, <1 μm), permeate (truly soluble phase, <1 kDa) and retentate
Winnie Luu et al.
Journal of lipid research, 56(4), 888-897 (2015-02-02)
Cholesterol is essential to human health, and its levels are tightly regulated by a balance of synthesis, uptake, and efflux. Cholesterol synthesis requires the actions of more than twenty enzymes to reach the final product, through two alternate pathways. Here
Xinyi Zhou et al.
Talanta, 147, 82-89 (2015-11-26)
Male infertility has become an important public health problem worldwide. Nowadays the diagnosis of male infertility frequently depends on the results of semen quality or requires more invasive surgical intervention. Therefore, it is necessary to develop a novel approach for
Michael Englert et al.
Analytical and bioanalytical chemistry, 407(18), 5503-5511 (2015-05-07)
Purification of individual fatty acids from vegetable oils by preparative liquid chromatography techniques such as countercurrent chromatography (CCC) is a challenging task due to the equivalent-chain-length (ECL) rule. It implies that one double bond equals two carbon atoms in the
Minghua Nie et al.
Chemosphere, 127, 109-116 (2015-02-14)
The occurrence and distribution of six selected estrogen compounds were investigated in samples of surface water, suspended particulate matter (SPM), and sediment in the Yangtze Estuary and its coastal areas over four seasons. With the exception of 17α-ethinylestradiol (EE2), all
Juan Ignacio Cacho et al.
Talanta, 146, 568-574 (2015-12-24)
A new procedure for the introduction of ionic liquid samples in gas chromatography (GC) is proposed. This procedure, based on microvial insert thermal desorption, allows the direct analysis of the compounds preconcentrated by ionic liquid based liquid-liquid microextraction (IL-LLME) using
David Cunningham et al.
Human molecular genetics, 24(10), 2808-2825 (2015-02-06)
NSDHL is a 3β-hydroxysterol dehydrogenase that is involved in the removal of two C-4 methyl groups in one of the later steps of cholesterol biosynthesis. Mutations in the gene encoding the enzyme are responsible for the X-linked, male lethal mouse
Joong-Seok Min et al.
Lipids in health and disease, 14, 77-77 (2015-07-24)
Cholesterol oxidation products (COPs) are produced during thermal processing of animal origin foods and are considered to have negative health impacts. The model systems are helpful to understand the impact of various factors on oxidation changes in foods during cooking
Muhammad I Khan et al.
Lipids in health and disease, 14, 89-89 (2015-08-12)
Cholesterol is an important biological compound; however, its oxidation products have been proven to be harmful to human health. Cooking, storage, and reheating methods significantly affect the safety of meat products, as they contribute to the production of cholesterol oxidation
Fabrício Flores-Nunes et al.
Environmental science and pollution research international, 22(22), 17267-17279 (2014-11-16)
The composition and concentration of substances in urban effluents are complex and difficult to measure. These contaminants elicit biological responses in the exposed organisms. Proteomic analysis is a powerful tool in environmental toxicology by evidencing alterations in protein expression due
Daniela F S Fonseca et al.
International journal of molecular sciences, 16(6), 14194-14209 (2015-06-26)
The lipophilic composition of wild Arbutus unedo L. berries, collected from six locations in Penacova (center of Portugal), as well as some general chemical parameters, namely total soluble solids, pH, titratable acidity, total phenolic content and antioxidant activity was studied
Loreto Quesada et al.
Journal of analytical toxicology, 39(9), 734-740 (2015-07-24)
We present a false-positive result of ecstasy (3,4-methylenedioxy-NN-methylamphetamine) screening due to the therapeutic use of fenofibrate, an antihyperlipidemic drug. Our hypothesis was that the main metabolite of fenofibrate, fenofibric acid, was responsible for this cross-reactivity on a DRI(®) Ecstasy Assay
Mauro Cunha Xavier Pinto et al.
Neuropharmacology, 89, 274-281 (2014-10-15)
Brain preconditioning is a protective mechanism, which can be activated by sub-lethal stimulation of the NMDA receptors (NMDAR) and be used to achieve neuroprotection against stroke and neurodegenerative diseases models. Inhibitors of glycine transporters type 1 modulate glutamatergic neurotransmission through
Yuichi Nodake et al.
Journal of dermatological science, 79(2), 119-126 (2015-05-28)
Staphylococcus epidermidis is an autologous bacterium that is beneficial to skin health. Our goal was to develop a novel, personalized basic cosmetic that exploits this characteristic. We conducted a double-blinded, randomized clinical trial on augmentation with S. epidermidis as a
Christophe Regnault et al.
BMC genomics, 15, 666-666 (2014-08-12)
Despite numerous studies suggesting that amphibians are highly sensitive to cumulative anthropogenic stresses, the role pollutants play in the decline of amphibian populations remains unclear. Amongst the most common aquatic contaminants, polycyclic aromatic hydrocarbons (PAHs) have been shown to induce
Ana Beatriz Zanqui et al.
Food chemistry, 188, 452-458 (2015-06-05)
Flaxseed (Linum usitatissimum L.) oil was obtained via subcritical n-propane fluid extraction (SubFE) under different temperatures and pressures with an average yield of 28% and its composition, purity and oxidative stability were compared to oils obtained via conventional solvent extraction
Mélanie Roffet-Salque et al.
Nature, 527(7577), 226-230 (2015-11-13)
The pressures on honeybee (Apis mellifera) populations, resulting from threats by modern pesticides, parasites, predators and diseases, have raised awareness of the economic importance and critical role this insect plays in agricultural societies across the globe. However, the association of
Sarah K Orr et al.
American journal of physiology. Lung cellular and molecular physiology, 308(9), L904-L911 (2015-03-15)
Resolution of inflammation is an active process driven by several new families of endogenous lipid mediators collectively coined specialized proresolving mediators (SPM). Here, we report a synthetic analog of resolvin D1 (RvD1) and aspirin-triggered RvD1, benzo-diacetylenic-17R-RvD1-methyl ester (BDA-RvD1), which was
David Rojo et al.
PloS one, 10(7), e0130675-e0130675 (2015-07-15)
There is a rising resistance against antimony drugs, the gold-standard for treatment until some years ago. That is a serious problem due to the paucity of drugs in current clinical use. In a research to reveal how these drugs affect
Satoshi Nakai et al.
Chemosphere, 136, 153-159 (2015-05-20)
Ozonation is believed to improve the biodegradability of organic compounds. In the present study, degradation of nonylphenol ethoxylates (NPEOs) was monitored in hybrid treatment systems consisting of ozonation and microbial degradation processes. We found that ozonation of NPEOs decreased, rather
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