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Kevork Hagopian et al.
PloS one, 10(4), e0124204-e0124204 (2015-04-17)
Shc proteins interact with the insulin receptor, indicating a role in regulating glycolysis. To investigate this idea, the activities of key glycolytic regulatory enzymes and metabolites levels were measured in skeletal muscle from mice with low levels of Shc proteins
M M Castillo-Ortega et al.
Materials science & engineering. C, Materials for biological applications, 46, 184-189 (2014-12-11)
Optimal conditions for the preparation of a composite material of fibers of cellulose acetate (CA) and poly(vinyl pyrrolidone) (PVP), containing epicatechin (Epic) within the fiber CA/PVP-Epic/CA, were found. The morphology and physical/chemical properties of the fibrous membranes containing CA, PVP
Y Wu et al.
Clinical and experimental immunology, 179(2), 277-293 (2014-09-18)
The role of NOD-like receptor family (NLRP3) has been confirmed in various inflammatory diseases. The association between NLRP3 and hyper-bileacidaemia during the sepsis remains unclear. We aimed to investigate whether NLRP3 silencing protects against the sepsis-induced hyper-bileacidaemia. Sepsis was induced
M M Parrilla Vázquez et al.
Journal of chromatography. A, 1356, 1-9 (2014-07-06)
Two dispersive liquid-liquid microextraction (DLLME) approaches including temperature-controlled ionic liquid dispersive liquid-liquid microextraction (TCIL-DLLME) and ultrasound-assisted ionic liquid dispersive liquid-liquid microextraction (US-IL-DLLME) were compared for the extraction of six benzoylurea insecticides (diflubenzuron, triflumuron, hexaflumuron, teflubenzuron, lufenuron and flufenoxuron) from wastewater
Yu Bon Man et al.
The Science of the total environment, 505, 261-268 (2014-12-03)
This study was to investigate removal efficiencies and profiles of 14 polybrominated diphenyl ether (PBDE) congeners by two different types of sewage treatment work (STW) in Hong Kong: Stonecutters Island STW (SCISTW) which uses chemically enhanced primary treatment (CEPT) process
Codrin Andrei et al.
PloS one, 9(10), e109836-e109836 (2014-10-30)
A substantial and stable increase of the current density Jsc of ruthenium (Ru) dye sensitized solar cells (DSC) of up to 16.18% and of the power efficiency of up to 25.5% is demonstrated in this article via plasmonic enhancement. The
Prabhu Thangadurai et al.
Journal of hazardous materials, 246-247, 245-256 (2013-01-15)
The efficiencies of reductive transformation of endosulfan by bimetallic systems consisting of zerovalent magnesium (Mg(0)) as the electron donor and three forms of palladium as the catalyst (Pd(0)-alumina, Pd(0)-carbon and Pd-K(2)PdCl(6)) were compared in this investigation. Results revealed that both
Takahiro Kawasaki et al.
Diabetes care, 25(2), 353-357 (2002-01-30)
To investigate fructose metabolic changes in patients with diabetes. Serum and urinary fructose concentrations were determined in healthy subjects (n = 23) and in nondiabetic (n = 23) and diabetic patients (n = 26). Fructose was measured using our newly
David S Wishart et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 871(2), 164-173 (2008-05-27)
With continuing improvements in analytical technology and an increased interest in comprehensive metabolic profiling of biofluids and tissues, there is a growing need to develop comprehensive reference resources for certain clinically important biofluids, such as blood, urine and cerebrospinal fluid
Rita Ambrus et al.
Journal of pharmaceutical and biomedical analysis, 76, 1-7 (2013-01-05)
Interest in submicron-sized drug particles has emerged from both laboratory and industrial perspectives in the last decade. Production of crystals in the nano size scale offers a novel way to particles for drug formulation solving formulation problems of drugs with
Pengzhan Liu et al.
Food chemistry, 160, 180-189 (2014-05-07)
Phenolic compounds in buds and leaves of three varieties of black currant in Finland were identified by HPLC-DAD-ESI-MS/MS. Forty-three phenolic compounds of flavonol glycosides, proanthocyanidins and phenolic acids were found in variety "Mikael" whereas only thirty-five in "Mortti" and "Jaloste
Amit Vij et al.
The international journal of biochemistry & cell biology, 57, 197-206 (2014-10-15)
Intracellular cAMP level and cAMP mediated responses are elevated when Leishmania are exposed to macrophage phagolysosome conditions (37 °C and pH 5.5). Phosphodiesterases play major role in cAMP regulation and in the present study we have cloned and characterized a
Masanobu Mizuta et al.
The Laryngoscope, 124(10), E411-E417 (2014-04-26)
Reactive oxygen species (ROS) are associated with aging. Astaxanthin (AST) is a strong antioxidant and has been reported to prevent various ROS-induced diseases. In the current study, we investigated the effect of AST on age-associated histological and mRNA changes of
Anke Böhmer et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 965, 173-182 (2014-07-18)
In healthy human subjects, less than 0.2% of l-arginine is converted to l-citrulline and nitric oxide (NO) by NO synthases (NOS), a metabolic pathway present in all cell types. Assessment of NOS activity in vitro and in vivo by measuring
M P Kalapos
Orvosi hetilap, 138(19), 1187-1193 (1997-05-11)
In the article, the routes of acetone metabolism are summarized and the conditions in which acetonemia occurs, are taken into account. Acetonemiae are classified as to be of exogenous and endogenous origin, and the biochemical mechanisms of the development of
K Holovská et al.
Journal of toxicology and environmental health. Part A, 78(6), 353-356 (2015-03-04)
Mobile communication systems are undoubtedly an environmental source of electromagnetic radiation (EMR). There is an increasing concern regarding the interactions of EMR with the humans. The aim of this study was to examine the effects of EMR on Wistar rat
Delphine Parrot et al.
Phytochemical analysis : PCA, 26(1), 23-33 (2014-08-19)
Lichens are self-sustaining partnerships comprising fungi as shape-forming partners for their enclosed symbiotic algae. They produce a tremendous diversity of metabolites (1050 metabolites described so far). A comparison of metabolic profiles in nine lichen species belonging to three genera (Lichina
Mateus B Pereira et al.
Journal of AOAC International, 97(4), 987-994 (2014-08-26)
Pollution of water sources by pesticides is a result of intensive use of these compounds, and the establishment of analytical methods for monitoring programs is very important. This paper presents a method for the determination of multiclass pesticide residues in
Jiahui Wu et al.
The American journal of pathology, 184(6), 1900-1910 (2014-04-15)
Myeloid cells are highly adaptable and may positively or negatively regulate angiogenesis dependent on the cognate and soluble signals they receive. Toll-like receptors (TLRs) initiate immune responses, orchestrate adaptive immune responses, and regulate vascular endothelial growth factor (VEGF)-mediated angiogenesis during
Huili Wang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 62-70 (2015-02-11)
Herein, we developed a novel integrated device to perform phase separation based on ultrasound-assisted salt-induced liquid-liquid microextraction for determination of five fluoroquinones (FQs) in human body fluids. The integrated device consisted of three simple HDPE components used to separate the
Pasquale Aragona et al.
TheScientificWorldJournal, 2014, 717835-717835 (2014-07-22)
Aim of the present work was to evaluate the effects of the trehalose on the corneal epithelium undergoing alcohol delamination. Twelve patients undergoing laser subepithelial keratomileusis (LASEK) were consecutively included in the study. The right eyes were pretreated with 3%
Siao-Syun Guan et al.
Oncotarget, 5(13), 4868-4880 (2014-06-21)
Colorectal cancer (CRC) is known as a common malignant neoplasm worldwide. The role of EGFR/HER2 in CRC is unclear. Afatinib is an irreversible EGFR/HER2 inhibitor. There were few studies of afatinib on CRC. Here, we investigated the protein levels/expressions of
Amal Kadimi et al.
ACS applied materials & interfaces, 6(12), 9418-9425 (2014-05-23)
This work aims to study how the magnitude, frequency, and duration of an AC electric field affect the orientation of two kinds of nanofibrillated cellulose (NFC) dispersed in silicone oil that differ by their surface charge density and aspect ratio.
Rakesh K Kumar et al.
Respirology (Carlton, Vic.), 20(1), 73-79 (2014-09-16)
Exposure to airborne particulate matter (PM) may promote development of childhood asthma and trigger acute exacerbations of existing asthma via injury to airway epithelial cells (AEC). We compared the response of AEC to ambient particulates with median aerodynamic diameters of
Fränze Progatzky et al.
Nature communications, 5, 5864-5864 (2014-12-24)
Prolonged ingestion of a cholesterol- or saturated fatty acid-enriched diet induces chronic, often systemic, auto-inflammatory responses resulting in significant health problems worldwide. In vivo information regarding the local and direct inflammatory effect of these dietary components in the intestine and
Jason W-L Eng et al.
Nature communications, 6, 6426-6426 (2015-03-11)
Cancer research relies heavily on murine models for evaluating the anti-tumour efficacy of therapies. Here we show that the sensitivity of several pancreatic tumour models to cytotoxic therapies is significantly increased when mice are housed at a thermoneutral ambient temperature
Becker Awqatty et al.
The Analyst, 139(20), 5230-5238 (2014-08-16)
The advanced functionality of portable devices such as smart phones provides the necessary hardware to potentially perform complex diagnostic measurements in any setting. Recent research and development have utilized cameras and data acquisition properties of smart phones to create diagnostic
Roberto A Maldonado et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(2), E156-E165 (2014-12-31)
Current treatments to control pathological or unwanted immune responses often use broadly immunosuppressive drugs. New approaches to induce antigen-specific immunological tolerance that control both cellular and humoral immune responses are desirable. Here we describe the use of synthetic, biodegradable nanoparticles
Marianna Stumpo et al.
International journal of pharmaceutics, 454(2), 678-685 (2013-07-10)
The scale-up of oil-containing polyamide nanocapsules produced by simultaneous interfacial polycondensation and solvent diffusion was successfully achieved. Up to 1,500 mL were produced by using a Y-shaped mixer device. The sizes of nanocapsules containing olive oil were modulated from 646
A W Jones et al.
Forensic science international, 37(4), 277-285 (1988-06-01)
Headspace gas chromatography was used to determine the concentration of ethanol and methanol in blood samples from 519 individuals suspected of drinking and driving in Sweden where the legal alcohol limit is 0.50 mg/g in whole blood (11 mmol/l). The
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