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Yumi Kohara et al.
Physiology & behavior, 140, 15-22 (2014-12-08)
Cognitive dysfunction due to higher blood glucose level has been reported previously. Genistein (GEN) is a phytoestrogen that we hypothesized might lead to improved memory, despite elevated blood glucose levels at the time of memory consolidation. To investigate this hypothesis
S-H Wen et al.
Free radical research, 48(8), 907-918 (2014-05-23)
15-F2t-isoprostane is not only a specific marker of lipid peroxidation but also demonstrated to have potent bioactivities and can exert deleterious effects via activating thromboxane A2 receptor (TxA2r). We already demonstrated that lipid peroxidation represents a mechanism of intestinal ischemia/reperfusion
M A Gales et al.
The Annals of pharmacotherapy, 29(5), 523-529 (1995-05-01)
To review the data examining the use of rapid infusion of amphotericin B in dextrose infusions. A MEDLINE search of the English-language literature and review of pertinent references' bibliographies was used to identify articles evaluating the effect of amphotericin B
Nayara Peixoto-Silva et al.
Life sciences, 95(1), 14-21 (2013-12-24)
Studies have demonstrated that early weaning can promote metabolic syndrome during adulthood and that obesity increases oxidative stress. Thus, we aimed to evaluate redox status in a pharmacological early weaning rodent model programmed for metabolic syndrome at adulthood. Lactating dams
Anamika Singh et al.
Thrombosis and haemostasis, 113(4), 750-758 (2015-02-06)
Diabetes mellitus (DM) patients have an increased incidence of cardiovascular events. Blood tissue factor-procoagulant activity (TF-PCA), the initiating mechanism for blood coagulation, is elevated in DM. We have shown that hyperglycaemia (HG), hyperinsulinaemia (HI) and combined HG+HI (induced using 24-hour
Laura C Tegtmeyer et al.
The New England journal of medicine, 370(6), 533-542 (2014-02-07)
Congenital disorders of glycosylation are genetic syndromes that result in impaired glycoprotein production. We evaluated patients who had a novel recessive disorder of glycosylation, with a range of clinical manifestations that included hepatopathy, bifid uvula, malignant hyperthermia, hypogonadotropic hypogonadism, growth
Hany M El-Bassossy et al.
Journal of translational medicine, 13, 82-82 (2015-04-19)
We have previously shown that hyperuricemia plays an important role in the vascular complications of insulin resistance (IR). Here we investigated the effect of xanthine oxidase (XO) inhibition on the cardiac complications of IR. IR was induced in rats by
L V Harmanchuk et al.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 59(2), 52-58 (2013-07-05)
The effect of mitokorrectine (complex native oligopeptides isolated from neonatal pig brain) on endothelial cells in culture was investigated. It was revealed that the drug concentration-dependently induces angiogenesis in vitro. Mitogen effect of Mitokorrectine was shown by MTT-test and routine
Guillaume Andre et al.
Journal of bacteriology, 190(21), 7079-7086 (2008-09-02)
The lysin motif (LysM) is a ubiquitous protein module that binds peptidoglycan and structurally related molecules. Here, we used single-molecule force spectroscopy (SMFS) to measure and localize individual LysM-peptidoglycan interactions on both model and cellular surfaces. LysM modules of the
Houda Banani et al.
International journal of food microbiology, 182-183, 1-8 (2014-05-24)
The yeast-like fungus Aureobasidium pullulans PL5 is a microbial antagonist against postharvest pathogens of fruits. The strain is able to produce hydrolases, including glucanases, chitinases and proteases. The alkaline serine protease gene ALP5 from A. pullulans was cloned, inserted into
Taha Haffar et al.
Biochemical and biophysical research communications, 459(1), 54-59 (2015-02-26)
Here we sought to evaluate the effect of palmitate on cytokine and PPAR activity/expression. We investigated the effect of BSA conjugated palmitate and oleate on PPAR activity, PPAR-α and δ expression, as well as the expression of cytokines and key
Mitchell B Sally et al.
The journal of trauma and acute care surgery, 76(1), 62-68 (2013-12-26)
The appropriate level of glucose control in organ donors after neurologic determination of death (DNDD) remains uncertain. We hypothesized that a glucose target of 180 mg/dL would be appropriate for optimizing organ transplantation rates and outcomes. Demographic, critical care, organ
Jocelyn Campbell et al.
Ecology, 94(5), 1186-1195 (2013-07-19)
Foliose lichens with cyanobacterial bionts (bipartite and tripartite) form a distinct assemblage of epiphytes strongly associated with humid microclimatic conditions in inland British Columbia. Previous research showed that these cyano- and cephalolichen communities are disproportionately abundant and species-rich on conifer
Metabolic quirks yield tumour hope.
Heidi Ledford
Nature, 508(7495), 158-159 (2014-04-11)
Arnaud Béduneau et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 87(2), 290-298 (2014-04-08)
Standard monoculture models utilizing Caco-2 monolayers were extensively used to mimic the permeability of the human intestinal barrier. However, they exhibit numerous limitations such as the lack of mucus layer, an overestimation of the P-gp-mediated efflux and a low paracellular
Martyna Kielmas et al.
Analytical and bioanalytical chemistry, 407(9), 2557-2567 (2015-02-01)
Glycation of α-crystallin is responsible for age- and diabetic-related cataracts, which are the main cause of blindness worldwide. We optimized the method of identification of lysine residues prone to glycation using the combination of LC-MS, isotopic labeling, and modified synthetic
Mesoamerica's mystery killer.
Jon Cohen
Science (New York, N.Y.), 344(6180), 143-147 (2014-04-12)
Krithika A Shetty et al.
Journal of pharmaceutical sciences, 104(2), 388-395 (2014-04-05)
Factor VIII (FVIII) replacement therapy in hemophilia A (HA) is complicated by a short half-life and high incidence of inhibitory antibody response against the protein. Phosphatidylinositol (PI) containing lipidic nanoparticles have previously been shown to reduce the immunogenicity and prolong
Megumi Ishii et al.
Archives of biochemistry and biophysics, 566, 26-35 (2014-12-21)
Obesity-associated insulin resistance is a major pathogenesis of type 2 diabetes mellitus and is characterized by defects in insulin signaling. High concentrations of plasma free fatty acids (FFAs) are involved in the etiology of obesity-associated insulin resistance. However, the detailed
Yu Huang et al.
Bioresource technology, 181, 224-230 (2015-02-07)
In this study, steam explosion pretreatment was performed in cotton stalks, leading to 5-6 folds enhancements on biomass enzymatic saccharification distinctive in Gossypium barbadense and Gossypium hirsutum species. Sequential 1% H2SO4 pretreatment could further increase biomass digestibility of the steam-exploded
V T Cheli et al.
Experimental neurology, 265, 69-83 (2014-12-30)
We have previously shown that the expression of voltage-operated Ca(++) channels (VOCCs) is highly regulated in the oligodendroglial lineage and is essential for proper oligodendrocyte progenitor cell (OPC) migration. Here we assessed the role of VOCCs, in particular the L-type
Rengasamy Palanivel et al.
Metabolism: clinical and experimental, 63(10), 1363-1373 (2014-08-12)
Adiponectin is known to confer its cardioprotective effects in obesity and type 2 diabetes, mainly by regulating glucose and fatty acid metabolism in cardiomyocytes. Dynamic actin cytoskeleton remodeling is involved in regulation of multiple biological functions, including glucose uptake. Here
Akwasi Atakora Amoako et al.
Fertility and sterility, 102(5), 1260-1267 (2014-09-13)
To determine whether changes in seminal plasma concentrations of the endogenous lipid signaling molecules palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) have significant effects on sperm quality. Biochemical and physiological studies of human seminal plasma and spermatozoa. Academic tertiary care medical center.
Corinne C Ramaley et al.
International journal of pharmaceutical compounding, 17(5), 436-438 (2014-01-28)
The objective of this study was to determine the compatibility of amiodarone hydrochloride with vasopressin during simulated Y-site administration. Amiodarone hydrochloride is compatible with vasopressin under simulated-use conditions when administered according to the Advanced Cardiac Life Support Guidelines. A simulated-use
R G Browning et al.
Annals of emergency medicine, 19(6), 683-687 (1990-06-01)
The empiric administration of 50% dextrose to all patients presenting to the ED with altered mental status is a standard of care predicated on the assumption that glucose administration is harmless to non-hypoglycemic patients. Considerable evidence now disputes this assumption.
B M Rovenko et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 85(5), 61-72 (2014-02-01)
The influence of 20 and 1% glucose and fructose, which were components of larval diet, on the level of oxidized proteins and lipids, low molecular mass antioxidant content as well as activities of antioxidant and associated enzymes in adult fruit
Fozia Shaheen et al.
Biochimica et biophysica acta, 1842(9), 1762-1769 (2014-06-28)
Telomerase reverse transcriptase (TERT) is a key component of the telomerase complex. By lengthening telomeres in DNA strands, TERT increases senescent cell lifespan. Mice that lack TERT age much faster and exhibit age-related conditions such as osteoporosis, diabetes and neurodegeneration.
Nadir Abuzeid et al.
Journal of ethnopharmacology, 157, 134-139 (2014-09-28)
The emergence of multidrug-resistant strains of Mycobacterium tuberculosis underscores the need for continuous development of new and efficient methods to determine the susceptibility of isolates of Mycobacterium tuberculosis in the search for novel antimycobacterial agents. Natural products constitute an important
Michael J Van Kanegan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(3), 963-968 (2014-01-17)
We have previously shown that the botanical drug candidate PBI-05204, a supercritical CO2 extract of Nerium oleander, provides neuroprotection in both in vitro and in vivo brain slice-based models for focal ischemia (Dunn et al., 2011). Intriguingly, plasma levels of
Hiu Yeung Lau et al.
Cancer biology & therapy, 15(9), 1280-1291 (2014-06-28)
Inhibitors of isoprenylcysteine carboxylmethyltransferase (Icmt) are promising anti-cancer agents, as modification by Icmt is an essential component of the protein prenylation pathway for a group of proteins that includes Ras GTPases. Cysmethynil, a prototypical indole-based inhibitor of Icmt, effectively inhibits
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