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Shoko Sawano et al.
Animal science journal = Nihon chikusan Gakkaiho, 85(12), 994-1000 (2014-09-05)
Regenerative intramuscular motor-innervation is thought to reside in the spatiotemporal expression of axon-guidance molecules. Our previous studies showed that resident myogenic stem cells, satellite cells, up-regulate a secreted neural-chemorepellent semaphorin 3A (Sema3A) during the early-differentiation period, in response to hepatocyte
Esmail Riahi et al.
Neurobiology of learning and memory, 119, 93-101 (2015-02-15)
The hippocampus receives sparse orexinergic innervation from the lateral hypothalamus and expresses a high level of orexin receptor. The function of orexin receptor in the regulation of hippocampal neural activity has never been investigated. In this study, in vivo single
Gina L Lonati et al.
The Journal of experimental biology, 218(Pt 16), 2620-2630 (2015-08-21)
Understanding toothed whale (odontocete) diving gas dynamics is important given the recent atypical mass strandings of odontocetes (particularly beaked whales) associated with mid-frequency naval sonar. Some stranded whales have exhibited gas emboli (pathologies resembling decompression sickness) in their specialized intramandibular
Chih-Kuang Chuang et al.
Orphanet journal of rare diseases, 9, 135-135 (2014-09-03)
The identification of acid mucopolysaccharide by the liquid chromatography/tandem mass spectrometry method (LC-MS/MS) of the predominant disaccharide units of glycosaminoglycans (GAGs) (chondroitin sulfate, CS; dermatan sulfate, DS; heparan sulfate, HS) after methanolysis is validated and applicable for mucopolysaccharidosis (MPS) type
Fatma Elzahraa Abdelrahman et al.
International journal of pharmaceutics, 490(1-2), 281-291 (2015-06-01)
The aim of this study was to enhance the risperidone delivery to the brain through the transnasal route via optimization of cubosomal gel. Cubosomes were prepared using glycerol mono-oleate (GMO), Pluronic F127 (PF127) and Tween 80 (T80). The prepared formulae
Albert T Hsu et al.
Shock (Augusta, Ga.), 44(2), 128-136 (2015-05-27)
Primed neutrophils that are capable of releasing matrix metalloproteinases (MMPs) into the circulation are thought to play a significant role in the pathophysiology of acute respiratory distress syndrome (ARDS). We hypothesized that direct measurement of plasma MMP-9 activity may be
Andreas Reisch et al.
ACS nano, 9(5), 5104-5116 (2015-04-22)
Ultrasmall polymer nanoparticles are rapidly gaining importance as nanocarriers for drugs and contrast agents. Here, a straightforward modular approach to efficiently loaded and stable sub-20-nm polymer particles is developed. In order to obtain ultrasmall polymer nanoparticles, we investigated the influence
Mehran Mehri
Poultry science, 93(7), 1862-1867 (2014-05-09)
The optimization algorithm of a model may have significant effects on the final optimal values of nutrient requirements in poultry enterprises. In poultry nutrition, the optimal values of dietary essential nutrients are very important for feed formulation to optimize profit
Jie Zhang et al.
The Biochemical journal, 461(3), 497-508 (2014-05-13)
Lantibiotics are ribosomally synthesized antimicrobial peptides containing unusual amino acids. As promising alternatives to conventional antibiotics, they have a high potential for alleviating the problem of emergent antibiotic resistance, with possible applications in many industries that have antibacterial demand. Bovicin
Christina L Gardner et al.
Journal of virology, 87(15), 8582-8590 (2013-05-31)
Recently, we compared amino acid sequences of the E2 glycoprotein of natural North American eastern equine encephalitis virus (NA-EEEV) isolates and demonstrated that naturally circulating viruses interact with heparan sulfate (HS) and that this interaction contributes to the extreme neurovirulence
Wei Tao et al.
Advanced healthcare materials, 4(8), 1203-1214 (2015-03-25)
A novel blended nanoparticle (NP) system for the delivery of anticancer drugs and its surprisingly high efficacy for cancer chemotherapy by blending a targeting polymer folic acid-poly(ethylene glycol)-b-poly(lactide-co-glycolide) (FA-PEG-b-PLGA) and a miscible structurally similar polymer D-α-tocopheryl polyethylene glycol 1000 succinate-poly(lactide-co-glycolide)
B Álvarez et al.
Developmental and comparative immunology, 51(2), 238-250 (2015-04-22)
A cDNA clone encoding a 380 a-a type 1 transmembrane protein with homology to human Siglec-3/CD33 was obtained from a swine small intestine library. An analysis of protein sequence identified two immunoglobulin-like domains, a transmembrane region, and a carboxi-terminal tail
Kenji Sakota et al.
The journal of physical chemistry. B, 119(32), 10334-10340 (2015-07-29)
Macromolecular crowding alters many biological processes ranging from protein folding and enzyme reactions in vivo to the precipitation and crystallization of proteins in vitro. Herein, we have investigated the effect of specific monovalent Hofmeister salts (NaH2PO4, NaF, NaCl, NaClO4, and
José Patricio Casanova et al.
Behavioural brain research, 296, 70-77 (2015-09-01)
A growing body of evidence suggests that learned fear may be related to the function of the interoceptive insular cortex. Using an auditory fear conditioning paradigm in rats, we show that the inactivation of the posterior insular cortex (pIC), the
Monika E Dolega et al.
Biomaterials, 52, 347-357 (2015-03-31)
3D culture systems are a valuable tool for modeling morphogenesis and carcinogenesis of epithelial tissue in a structurally appropriate context. We present a novel approach for 3D cell culture based on a flow-focusing microfluidic system that encapsulates epithelial cells in
Amy V Gore et al.
The journal of trauma and acute care surgery, 79(1), 48-52 (2015-06-20)
Rodent lungs undergo full histologic recovery within 1 week following unilateral lung contusion (LC). However, when LC is followed by hemorrhagic shock (HS), healing is impaired. We hypothesize that the intravenous administration of mesenchymal stem cells (MSCs) in animals undergoing
Jodee L Johnson et al.
Pancreas, 44(1), 144-151 (2014-09-23)
This study aimed to evaluate the ability of luteolin (Lut), gemcitabine (Gem), and their combination (Lut + Gem) to prevent the growth of pancreatic tumors in vivo. The antitumor effect of intraperitoneally administered Lut, Gem, and Lut + Gem was
Raffaella Alò et al.
Brain research bulletin, 118, 65-77 (2015-09-27)
Recent evidences indicate that cerebral neurotrophic factors like vascular endothelial growth factor plus signaling pathways of the glutamatergic neuroreceptor system (L-Glu) are determinant modulators of depression-like states. In the present study, the type of interaction(s) exerted by the AMPAergic antagonist
Jiyoung Kim et al.
Macromolecular bioscience, 15(8), 1081-1090 (2015-04-02)
The accurate diagnosis and proper therapy for cancer are essential to improve the success rate of cancer treatment. Here, we demonstrated that the vitamin Bc -bearing hydrophilic photosensitizer conjugate folic acid-polyethylene glycol-pheophorbideA (FA-PEG-PheoA) has been synthesized for the intracellular diagnosis
F I Al-Jenoobi et al.
Drug research, 65(6), 312-316 (2014-07-06)
The present study was conducted to investigate the effect of commonly used herb Commiphora myrrha on the pharmacokinetic profile of theophylline (narrow therapeutic index drug) in rabbits. In the experimental groups, theophylline (16 mg/kg) was given orally to the rabbits.
Jeffrey H Walton et al.
Biochemical and biophysical research communications, 463(4), 479-482 (2015-05-23)
Dynamic Contrast Enhanced (DCE) MRI is increasingly being used to assess changes in capillary permeability. Most quantitative techniques used to measure capillary permeability are based on the Fick equation that requires measurement of signal reflecting both plasma and tissue concentrations
Watcharaporn Kamjumphol et al.
The American journal of tropical medicine and hygiene, 93(5), 1058-1065 (2015-09-02)
The resilience of Burkholderia pseudomallei, the causative agent of melioidosis, was evaluated in control soil microcosms and in soil microcosms containing NaCl or FeSO4 at 30°C. Iron (Fe(II)) promoted the growth of B. pseudomallei during the 30-day observation, contrary to
Carolien Grammen et al.
International journal of pharmaceutics, 475(1-2), 238-244 (2014-09-02)
The purpose of this work was to design and evaluate a vaginal film delivery system for UAMC01398, a novel non-nucleoside reverse transcriptase inhibitor currently under investigation for use as an anti-HIV microbicide. UAMC01398 (1mg) films consisting of hydroxypropylmethylcellulose (HPMC) and
Yitong J Zhang et al.
Journal of pharmaceutical sciences, 104(5), 1815-1824 (2015-03-11)
Artemisinin (ART), a well-known antimalaria drug, also exhibits anticancer activities. We previously reported a group of novel dimeric artemisinin piperazine conjugates (ADPs) possessing pH-dependent aqueous solubility and a proof-of-concept lipid nanoparticle formulation based on natural egg phosphatidylcholine (EPC). EPC may
Qinglin Han et al.
Journal of virology, 88(16), 9379-9390 (2014-06-13)
Viruses take advantage of host posttranslational modifications for their own benefit. It was recently reported that influenza A virus proteins interact extensively with the host sumoylation system. Thereby, several viral proteins, including NS1 and M1, are sumoylated to facilitate viral
Xu Wang et al.
The Analyst, 140(5), 1453-1458 (2015-01-21)
A simple, sensitive and cost-effective method for the analysis of the mycotoxin aflatoxin B1 (AFB1) has been established based on controlled growth of immunogold. AFB1-BSA conjugate modified magnetic beads were employed as capture probe and anti-AFB1 antibody-coated gold colloids were
Riyanto Heru Nugroho et al.
Journal of bioscience and bioengineering, 120(4), 396-404 (2015-03-22)
Acid stress has been reported to inhibit cell growth and decrease productivity during bio-production processes. In this study, a metabolomics approach was conducted to understand the effect of lactic acid induced stress on metabolite pools in Saccharomyces cerevisiae. Cells were
Benjamin Bloch et al.
Acta orthopaedica Belgica, 81(2), 225-232 (2015-08-19)
We present the outcome of 270 cemented titanium alloy femoral stems. These patients were followed up annually both clinically and radiologically, and were included up until their last follow-up. 120 patients completed a 10-year follow-up. The 10-year survival of the
Raza Akrami et al.
Fish & shellfish immunology, 45(2), 828-834 (2015-06-13)
The present study was aimed at determining the effects of dietary onion powder on growth, innate immune response and hemato-biochemical parameters of beluga juvenile (Huso huso). Basal diets containing onion powder 0 (control), 0.5 and 1% of feed were fed
Hui Zhong et al.
International journal of biological sciences, 16(8), 1450-1462 (2020-03-27)
Keratinocyte is the predominant cell type in the epidermis of skin, and it provides the protective barrier function for the body. Various signaling pathways have been implicated in keratinocyte differentiation in animal models; However, their temporal regulation and interactions are
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