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APPI Dopants - Solvents and Post-Column Additives for Photo-Ionization
We presents an article concerning APPI Dopants - Solvents and post-column additives for photo-ionization.
Extended Lifetime Ethanol Metabolites and Method Development for Ethyl Sulfate and Ethyl Glucuronide Separation
Review of clinically relevant ethanol metabolites and analytical method development for the analysis of ethyl glucuronide and ethyl sulfate in urine matrix.
Analytical Reference Standards: Synthesis and Characterization
As a major metabolite of methylphenidate (1, Ritalin), ±-threo-Ritalinic acid (2) is of clinical relevance.
Serum Lipidomics Profiling using an Ascentis Express Fused-Core C18 Column
Sigma-Aldrich presents an article on serum lipidomics profiling using an Ascentis Express Fused-Core C18 column.
Certified Reference Materials: Synthesis and Characterization of Cocaine N-oxide HCl
Cocaine is one of the most widespread illicit drugs of abuse in the US. Cocaine N-oxide is a metabolite of cocaine formed by cytochrome P-450 mediated oxidation of cocaine.1,2
Fast and Accurate Analysis of Vitamin D Metabolites Using Novel Chromatographic Selectivity and Sample Preparation
Vitamin D deficiency has become a topic of interest in recent publications. Vitamin D regulates the absorption of calcium within the digestive track and is important to promote proper bone growth and prevent osteoprosis in older adults.
Development of Simple and Rapid Workflows for Quantitation of Infliximab and Adalimumab in Human Serum by LC-MS/MS
Development of Simple and Rapid Workflows for Quantitation of Infliximab and Adalimumab in Human Serum by LC-MS/MS
Molecularly Imprinted Polymer SPE- Acid NSAIDs from Muscle
A new, successfully developed and validated LC-MS-MS method allowing the extraction of NSAIDs from poultry muscle tissue using Molecularly Imprinted Polymer (MIP) SPE.
HybridSPE®-Phospholipid Technology
Innovative solid phase extraction (SPE) technology from Supelco, utilizes phospholipid retention mechanism based on highly selective interaction between proprietary zirconia ions (bonded to the stationary phase) and the phosphate moiety consistent with phospholipids and proteins.
Methods and matrices for mass spectrometry of glycans
Mass Spectrometry of Glycans, method comparison and products
Derivatization Agents for LC/MS – An Improved Detection of Estradiol with ESI-MS
Improved LC/MS Detection of Estradiol using 4-(Dimethylamino) benzoyl chloride (DMABC) derivatization agent relative to dansyl chloride.
Investigating Matrix Interference in Analysis of Antiarrhythmic Cardiac Drugs in Plasma
For efficient therapeutic drug monitoring, it is important for clinicians to have access to fast and robust analytical methods for accurate assessment of drug efficacy. Industrial trends toward highly specific LC/MS applications over traditional immunoassay have resulted in the need
Method Optimization for LC-MS Analysis of Vitamin D Metabolite Critical Pairs in Serum
Novel sample prep technique coupled with the unique selectivity of the Ascentis Express F5 column enables a fast and simplified bioanalytical method for associated vitamin D metabolites.
Online Solid Phase Extraction and LC/MS Analysis of Thyroid Hormones in Human Serum
An online SPE-LC/MS method has been developed for the rapid detection of thyroid hormones in human serum with minimal hands on effort and time-consuming steps.
Use of 13C Isotopes
Dr. Pratip Bhattacharya, California Institute of Technology. "Stable isotopes have played a very useful role in MR research which involves both MRI and MRS.
Ion-Suppression & Phospholipid Contamination
We are presenting an article focusing on ion-suppression and phospholipid contamination and some of their major causes and difficulties.
Analysis of Tetrahydrocannabinol (THC) and Carboxytetrahydrocannabinol (THCCOOH) in Surface Waters by SPME and GC/MS
Analysis of Tetrahydrocannabinol (THC) and Carboxytetrahydrocannabinol (THCCOOH) in Surface Waters by SPME and GC/MS
LC/MS/MS Method for Determination of Glyphosate, AMPA, and Glufosinate in Cereals
Glyphosate and related compounds are measured in oatmeal and infant cereal using ion-exchange polymer-based particles for HPLC and SPE. Low level detection was obtained.
New Certified Reference Materials for α‑Lactalbumin, β‑Lactoglobulin A & B, and Lactoferrin
We have developed Certified Reference Materials (CRMs) of fully intact milk proteins that allow accurate testing of the most critical proteins in infant formula; help labs to develop and test infant formula products with high accuracy, while ensuring legal and
Chiral and Achiral LC-MS Analysis of Warfarin™ in Plasma Samples
Clinical laboratories are beginning to reap the benefits of LC-MS in terms of its sensitivity, specificity, throughput, and potential to reduce cost per sample. The purpose of this study was to demonstrate the LC-MS analysis of Warfarin in plasma samples
The Extraction of Amphetamine and Related Drugs using Molecularly Imprinted Polymer SPE
The Extraction of Amphetamine and Related Drugs using Molecularly Imprinted Polymer SPE
The Effect of Container Materials on Production of Light Induced Milk – A Study Using SPME-GC-MS
Various plastics used as barriers to the production of off-flavors in light exposed milk were examined using HS-SPME with a new Carboxen®/PDMS coated Nitinol fiber followed by GC-MS analysis allowing detection of low MW analytes at levels <1 ng/mL.
Synthesis and HILIC/MS Analysis of Acylcarnitines
HILIC mode chromatography using an Ascentis® Express OH5 resolved the majority of the acyl-L-carnitines tested. It may be possible to use MS/MS and particular fragment ions to resolve the two coeluting pairs.
Bioanalytical Applications for SPME
BioSPME Tips enable direct 1-step sample handling of biofluids, eliminating the need for time-consuming sample preparation steps used in current bioanalytical analyses
Learn more about Bioethanol as a renewable, alternative fuel traditionally produced by the yeast fermentation of sugar.
Mass Spectrometry
What is Mass Spectrometry or MS? What is it used for and how does it work? Read this detailed article with diagrams and example graphs to understand how to use mass spec in your research.
Melamine Analysis via GC-MS
Sigma-Aldrich presents an article about the analysis of melamine and related compounds in dog food with the use of more economical gas chromatography-mass spectrometry (GC-MS) instrumentation.
Ultrapure Water for LC MS Biomedical Analyses
Suitability of reagent water for LC-MS biomedical analyses evaluation and the role of water quality in achieving sensitive and reliable LC-MS analysis.
How to Maximize Sensitivity in LC-MS
Various measures and options for maximized LC-MS sensitivity and low limit of detection (LOD) are shown on this page. Each and every tip avoids contaminations causing signal suppression, adduct formation, elevated background noise and increased spectrum complexity.
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