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Shin-Ichiro Masunaga et al.
SpringerPlus, 3, 128-128 (2015-02-13)
To examine the effect of the type and the concentration of neutron capture agents on the values of compound biological effectiveness (CBE) in boron neutron capture therapy. After the subcutaneous administration of a (10) B-carrier, boronophenylalanine- (10) B (BPA) or
Olga I Kahn et al.
Molecular biology of the cell, 26(1), 66-77 (2014-10-31)
Kinesin-5 is a slow homotetrameric motor protein best known for its essential role in the mitotic spindle, where it limits the rate at which faster motors can move microtubules. In neurons, experimental suppression of kinesin-5 causes the axon to grow
Gary S L Peh et al.
Scientific reports, 5, 9167-9167 (2015-04-01)
The global shortage of donor corneas has garnered extensive interest in the development of graft alternatives suitable for endothelial keratoplasty using cultivated primary human corneal endothelial cells (CECs). We have recently described a dual media approach for the propagation of
Kyla D Baron et al.
Biochimica et biophysica acta, 1853(7), 1683-1692 (2015-04-18)
The Ste20-like kinase SLK plays a pivotal role in cell migration and focal adhesion turnover and is regulated by the LIM domain-binding proteins Ldb1 and Ldb2. These adapter proteins have been demonstrated to interact with LMO4 in the organization of
Xiaowen Huang et al.
Mycopathologia, 180(3-4), 159-164 (2015-05-25)
Penicillium marneffei, the only known dimorphic and pathogenic species in the genus of Penicillium, is responsible for severe to deadly infection in immunocompromised patients. In this study, P. marneffei was able to infect the greater wax moth Galleria mellonella. The
Shiyu Zhao et al.
The Journal of surgical research, 191(2), 290-301 (2014-05-02)
Superparamagnetic iron oxide magnetic nanomaterials (SPIO) are tracers used for treatment of central nervous and cardiovascular system complications in animal models. The present study investigated survival and proliferation of SPIO-labeled bone marrow mesenchymal stem cells (BMSCs) to determine their potential
Jee-Yeong Jeong et al.
Journal of hematology & oncology, 8, 37-37 (2015-04-19)
Thrombocytopenia is a significant problem in patients with relapsed or refractory multiple myeloma, precipitating a need for supportive platelet transfusions and necessitating decreases in delivered doses of chemotherapy. Eltrombopag is a non-peptide, small molecule thrombopoietin (TPO) receptor agonist that promotes
Fatima-Zohra Braikia et al.
Molecular and cellular biology, 35(19), 3370-3380 (2015-07-22)
Eukaryotic gene expression is often controlled by distant regulatory elements. In developing B lymphocytes, transcription is associated with V(D)J recombination at immunoglobulin loci. This process is regulated by remote cis-acting elements. At the immunoglobulin heavy chain (IgH) locus, the 3'
Aleksey V Zaitsev et al.
Journal of neuroscience research, 93(3), 454-465 (2014-11-02)
Alterations in inhibitory and excitatory neurotransmission play a central role in the etiology of epilepsy, with overstimulation of glutamate receptors influencing epileptic activity and corresponding neuronal damage. N-methyl-D-aspartate (NMDA) receptors, which belong to a class of ionotropic glutamate receptors, play
Reshmi Parameswaran et al.
Molecular cancer therapeutics, 13(6), 1567-1577 (2014-05-16)
B-cell activating factor receptor (BAFF-R) is expressed on precursor B acute lymphoblastic leukemia (pre-B ALL) cells, but not on their pre-B normal counterparts. Thus, selective killing of ALL cells is possible by targeting this receptor. Here, we have further examined
Yue-Juan Chen et al.
Journal of molecular neuroscience : MN, 56(4), 999-1008 (2015-06-06)
Our previous study has showed that co-grafted Schwann cells (SCs) promote proliferation and migration of the grafted oligodendrocyte precursor cells (OPCs). However, how the co-grafted SCs affect OPCs has not been clarified. In the present study, we confirmed that SC-induced
Mohd Shahab et al.
PloS one, 9(6), e99884-e99884 (2014-06-19)
Wolbachia, an endosymbiont of filarial nematode, is considered a promising target for treatment of lymphatic filariasis. Although functional characterization of the Wolbachia peptidoglycan assembly has not been fully explored, the Wolbachia genome provides evidence for coding all of the genes
Hisanobu Ota et al.
PloS one, 10(4), e0123733-e0123733 (2015-04-16)
Relationship between microalbuminuria and worse outcome of coronary artery disease patients is discussed, but its underlying pathophysiological mechanism remains unclear. We investigated the role of microalbuminuria to the function of endothelial progenitor cells (EPCs), that might affect to outcome of
Mengran Zhang et al.
Inflammation, 38(1), 278-289 (2014-10-11)
Activation of hepatic stellate cell (HSC) is the central event in liver fibrosis. NS5ATP9 is related to many malignant tumors, but little is known about its function in HSC activation. The aim of this study is to investigate the role
Tzyy-Harn Yeh et al.
Journal of drug targeting, 22(6), 528-535 (2014-04-16)
In some cancer cells, translocation of cytochrome c (Cyt c) from mitochondria to the cytoplasma is inhibited. This inhibition prevents cells from undergoing apoptotic cell death and can lead to uncontrolled cell growth. Increasing cytoplasmic concentration of Cyt c can
Qing Xie et al.
Biomaterials, 66, 67-82 (2015-07-22)
Mesenchymal stem cells (MSCs) have been extensively applied in the field of tissue regeneration. MSCs derived from various tissues exhibit different characteristics. In this study, a cluster of cells were isolated from human ethmoid sinus mucosa membrane and termed as
Young-Jae Kim et al.
Journal of microbiology (Seoul, Korea), 52(8), 702-708 (2014-08-08)
Tannerella forsythia is considered a pathogen of periodontitis and forms a biofilm with multi-species bacteria in oral cavity. Lipopolysaccharide is a powerful immunostimulator and induces inflammation and shock. The purpose of this study was to investigate the characteristics of T.
Mingxing Tian et al.
Infection and immunity, 82(7), 2840-2850 (2014-04-23)
We previously showed that Brucella abortus rough mutant strain 2308 ΔATP (called the ΔrfbE mutant in this study) exhibits reduced intracellular survival in RAW264.7 cells and attenuated persistence in BALB/c mice. In this study, we performed microarray analysis to detect
Brian J Page et al.
Journal of the American College of Cardiology, 65(7), 684-697 (2015-02-14)
The time course and extent of recovery after revascularization of viable dysfunctional myocardium are variable. Although fibrosis is a major determinant, myocyte structural and molecular remodeling may also play important roles. This study sought to determine whether persistent myocyte loss
Antonietta Rizzo et al.
International immunopharmacology, 22(1), 66-72 (2014-07-01)
Chlamydia pneumoniae is an obligate intracellular Gram-negative bacterium that causes persistent infections with a tendency to chronicize, which might motivate the resistance of chlamydiae to some commonly used antibiotics. The bisphosphonates are an emerging class of drugs mostly used in
Julien Barthes et al.
Biomaterials science, 3(9), 1302-1311 (2015-08-12)
Mammalian cell culture is the starting point in many research studies focusing on biomedical applications. However, researchers have little control over the standardized cell microenvironment parameters. Here a modular ECM-mimicking surface coating for cell culture environment is designed. This substrate
Xianghua Lin et al.
Clinical laboratory, 61(5-6), 561-567 (2015-06-30)
Flow cytometry is a potent tool to dissect the phenotypes and functions of cell subsets by measuring multiple parameters on a single-cell basis. However, intracellular staining may be time consuming and more steps, particularly in cytokines, could be problematic for
Linghui Dai et al.
Journal of translational medicine, 13, 200-200 (2015-06-25)
Mesenchymal stem cells (MSCs) are regarded as a promising cell-based therapeutic tool for tendon repair. This study aimed to compare the different tenogenic differentiation capacities of the three types of MSCs in the presence of bone morphogenic protein 12 (BMP-12).
Loredana Cifaldi et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(11), 3037-3046 (2015-08-08)
Systemic juvenile idiopathic arthritis (JIA) is associated with high levels of interleukin-6 (IL-6) in the serum and synovial fluid, and impairment of natural killer (NK) cell function is often observed. This study was undertaken to evaluate a possible link between
Jeroen D Langereis et al.
mBio, 5(4), e01478-e01414 (2014-07-24)
Nontypeable Haemophilus influenzae is a frequent cause of noninvasive mucosal inflammatory diseases but may also cause invasive diseases, such as sepsis and meningitis, especially in children and the elderly. Infection by nontypeable Haemophilus influenzae is characterized by recruitment of neutrophilic
Ceren Kutlu et al.
Journal of microencapsulation, 31(7), 700-707 (2014-06-26)
The chitosan scaffold, which has both of anticancer and antivascularization effects, was developed for using in local therapy of brain tumours. This is why, poly-lactic-co-glycolic acid (50:50) nanoparticles (~200 nm) including an anticancer drug, 5-fluorouracil (5-FU), were prepared by emulsion-solvent
Mohammad Anvari et al.
International journal of biological macromolecules, 79, 894-902 (2015-06-10)
The rheological and structural characteristics of fish gelatin (FG)-gum arabic (GA) complex coacervate phase, separated from an aqueous mixture of 1% FG and 1% GA at pH 3.5, were investigated as influenced by phase separation temperature. Decreasing the phase separation
Young-Min Kim et al.
Biomaterials, 34(18), 4493-4500 (2013-03-19)
An approach for application of cell penetration to selective small interference RNA (siRNA) localized delivery system, cell penetrable nano-polyplex assembled hydrogel system, is presented. The cell penetrable nano-polyplex assembled hydrogelisprepared by protamine conjugation to poly(organophos-phazene) and inducement of nano-polyplexes with
Kerstin Sandholm et al.
PloS one, 9(9), e108013-e108013 (2014-09-30)
Here we investigated the role of complement activation in phagocytosis and the release of cytokines and chemokines in response to two clinical isolates: Borrelia afzelii K78, which is resistant to complement-mediated lysis, and Borrelia garinii LU59, which is complement-sensitive. Borrelia
Łukasz Uram et al.
International journal of nanomedicine, 10, 5647-5661 (2015-09-18)
The intracellular localization and colocalization of a fluorescently labeled G3 amine-terminated cationic polyamidoamine (PAMAM) dendrimer and its biotin-pyridoxal (BC-PAMAM) bioconjugate were investigated in a concentration-dependent manner in normal human fibroblast (BJ) and squamous epithelial carcinoma (SCC-15) cell lines. After 24
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