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Hellmuth Lilienthal et al.
Toxicology letters, 224(1), 32-39 (2014-01-25)
Since knowledge about toxic effects of non-dioxinlike (NDL) PCBs is fragmentary, regulatory panels have concluded that risk assessment of these congeners is hampered or impossible. As the dopaminergic system is one of the main targets in PCB-related neurotoxic effects after
Hongwon Kim et al.
Biochemical and biophysical research communications, 446(4), 1211-1218 (2014-04-01)
Midbrain dopaminergic (DA) neurons are involved in the regulation of voluntary movement and in emotion-related behaviors and are affected in Parkinson's disease (PD). The homeodomain transcription factor Pitx3, which is uniquely expressed in midbrain DA neurons, plays a critical role
Jin Wu et al.
Journal of leukocyte biology, 97(1), 191-200 (2014-10-25)
MDSCs accumulate in tumor-bearing animals and cancer patients and are a major factor responsible for cancer-induced immunosuppression that limits effective cancer immunotherapy. Strategies aimed at effectively inhibiting the function of MDSCs are expected to enhance host anti-tumor immunity and improve
Florian Ponzio et al.
Journal of colloid and interface science, 459, 29-35 (2015-08-12)
Polydopamine (PDA) coatings appear as a universal functionalization methodology allowing to coat the surface of almost all kinds of known materials with a conformal, stable, robust and reactive material. Relatively few investigations were dedicated to the incorporation of other molecules
Kevin Wilhelmsen et al.
The Journal of biological chemistry, 289(19), 13079-13100 (2014-03-20)
Although cannabinoids, such as Δ(9)-tetrahydrocannabinol, have been studied extensively for their psychoactive effects, it has become apparent that certain cannabinoids possess immunomodulatory activity. Endothelial cells (ECs) are centrally involved in the pathogenesis of organ injury in acute inflammatory disorders, such
Max F K Happel et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(4), 1234-1247 (2014-01-24)
Dopaminergic neurotransmission in primary auditory cortex (AI) has been shown to be involved in learning and memory functions. Moreover, dopaminergic projections and D1/D5 receptor distributions display a layer-dependent organization, suggesting specific functions in the cortical circuitry. However, the circuit effects
Moe H Aung et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(3), 726-736 (2014-01-17)
Dopamine (DA) functions as an essential neuromodulator in the brain and retina such that disruptions in the dopaminergic system are associated with common neurologic disorders such as Parkinson's disease. Although a reduction in DA content has been observed in diabetes
Tiziana Alberio et al.
Biochimica et biophysica acta, 1842(9), 1816-1822 (2014-07-08)
Altered dopamine homeostasis plays a key role in the pathogenesis of Parkinson's disease. The generation of reactive oxygen species by spontaneous dopamine oxidation impairs mitochondrial function, causing in turn an enhancement of oxidative stress. Recent findings have highlighted the role
Arati A Inamdar et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(48), 19561-19566 (2013-11-13)
Parkinson disease (PD) is the most common movement disorder and, although the exact causes are unknown, recent epidemiological and experimental studies indicate that several environmental agents may be significant risk factors. To date, these suspected environmental risk factors have been
E R Gasenzer et al.
Deutsche medizinische Wochenschrift (1946), 139(51-52), 2642-2650 (2014-12-10)
Purpose of this essay is to provide a historical overview how music has dealt with the emotion and sensation of pain, as well as an overview over the more recent medical research into the relationship of music and pain. Since
Toshihiko Shirafuji et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9268-9280 (2014-07-11)
Protein kinase C (PKC) has been implicated in the control of neurotransmitter release. The AS/AGU rat, which has a nonsense mutation in PKCγ, shows symptoms of parkinsonian syndrome, including dopamine release impairments in the striatum. Here, we found that the
David Vauzour et al.
The Biochemical journal, 463(1), 41-52 (2014-06-19)
Parkinson's disease is characterized by the progressive and selective loss of dopaminergic neurons in the substantia nigra. It has been postulated that endogenously formed CysDA (5-S-cysteinyldopamine) and its metabolites may be, in part, responsible for this selective neuronal loss, although
Andrew S Hart et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(3), 698-704 (2014-01-17)
Making predictions about the rewards associated with environmental stimuli and updating those predictions through feedback is an essential aspect of adaptive behavior. Theorists have argued that dopamine encodes a reward prediction error (RPE) signal that is used in such a
Jackson J Cone et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(14), 4905-4913 (2014-04-04)
Brief, high-concentration (phasic) spikes in nucleus accumbens dopamine critically participate in aspects of food reward. Although physiological state (e.g., hunger, satiety) and associated hormones are known to affect dopamine tone in general, whether they modulate food-evoked, phasic dopamine specifically is
Dopamine vs nesiritide for acute heart failure with renal dysfunction.
Sachin Kumar
JAMA, 311(15), 1565-1565 (2014-04-17)
Michael L Granda et al.
American journal of physiology. Renal physiology, 307(1), F116-F121 (2014-05-09)
The intrarenal dopamine system is important for signaling and natriuresis, and significant dysfunction is associated with hypertension and kidney disease in ex vivo studies. Dopamine receptors also modulate and are modulated by the renin-angiotensin-aldosterone system. Here, we show the first
Gambling on the brain.
Ferris Jabr
Scientific American, 309(5), 28-28 (2013-11-29)
Marquitta L Smith et al.
Life sciences, 110(1), 1-7 (2014-06-01)
The molecular mechanisms for the loss of 3,4-dihydroxyphenylalanine (l-dopa) efficacy during the treatment of Parkinson's disease (PD) are unknown. Modifications related to catecholamine metabolism such as changes in l-dopa and dopamine (DA) metabolism, the modulation of catecholamine enzymes and the
[In vitro pharmacology of antipsychotics at human dopamine D2 and D3 receptors].
Yoshihiro Tadori et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 144(6), 265-271 (2014-12-11)
Marta E Soden et al.
Neuron, 80(4), 997-1009 (2013-11-12)
The calcium-activated small conductance potassium channel SK3 plays an essential role in the regulation of dopamine neuron activity patterns. Here we demonstrate that expression of a human disease-related SK3 mutation (hSK3Δ) in dopamine neurons of mice disrupts the balance between
Debra A Cooper et al.
The Journal of pharmacology and experimental therapeutics, 350(1), 144-152 (2014-05-13)
Disulfiram has shown promise as a pharmacotherapy for cocaine dependence in clinical settings, although it has many targets, and the behavioral and molecular mechanisms underlying its efficacy are unclear. One of many biochemical actions of disulfiram is inhibition of dopamine
Magali Cazade et al.
Molecular pharmacology, 85(2), 218-225 (2013-11-12)
T-type calcium channels (T/Ca(v)3-channels) are implicated in various physiologic and pathophysiologic processes such as epilepsy, sleep disorders, hypertension, and cancer. T-channels are the target of endogenous signaling lipids including the endocannabinoid anandamide, the ω3-fatty acids, and the lipoamino-acids. However, the
Eashita Das et al.
FEBS letters, 588(9), 1706-1714 (2014-03-25)
MicroRNA (miRNA) regulates expression of protein coding genes and has been implicated in diverse cellular processes including neuronal differentiation, cell growth and death. To identify the role of miRNA in neuronal differentiation, SH-SY5Y and IMR-32 cells were treated with dopamine
Silvia Capellino et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(10), 2685-2693 (2014-06-27)
Observations in both animal models of arthritis and patients with rheumatoid arthritis (RA) suggest a role for dopamine and its receptors in RA. Because synovial fibroblasts (SFs) contribute to inflammation and joint destruction in RA, the aim of this study
Eric Set et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(26), 9615-9620 (2014-07-01)
Game theory describes strategic interactions where success of players' actions depends on those of coplayers. In humans, substantial progress has been made at the neural level in characterizing the dopaminergic and frontostriatal mechanisms mediating such behavior. Here we combined computational
[The reward system of the brain: the brain loves surprises].
Claudia Bruhn
Deutsche medizinische Wochenschrift (1946), 139(18), 928-929 (2014-06-03)
Anne-Sophie Van Rompuy et al.
Journal of neuropathology and experimental neurology, 73(2), 159-174 (2014-01-16)
Mutations in the parkin gene are the most common cause of early-onset autosomal recessive Parkinson disease (PD). The pathogenic mechanisms of how parkin mutations lead to the development of PD are not fully understood. Studies of cell cultures and of
Aetiology: Searching for schizophrenia's roots.
Emily Elert
Nature, 508(7494), S2-S3 (2014-04-04)
Nenad Medic et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(50), 16856-16864 (2014-12-17)
Although there is a rich literature on the role of dopamine in value learning, much less is known about its role in using established value estimations to shape decision-making. Here we investigated the effect of dopaminergic modulation on value-based decision-making
Amy K Wagner et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(8), 1328-1339 (2014-05-23)
Dopamine (DA) neurotransmission influences cognition and recovery after traumatic brain injury (TBI). We explored whether functional genetic variants affecting the DA transporter (DAT) and D2 receptor (DRD2) impacted in vivo dopaminergic binding with positron emission tomography (PET) using [(11)C]βCFT and
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