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Szczepan Mogilski et al.
Pharmacology, biochemistry, and behavior, 133, 99-110 (2015-04-08)
The aim of this study was to evaluate the analgesic as well as anti-inflammatory activities of the new pyrrolo[3,4-d]pyridazinone derivatives. Moreover, the present study attempted to assess some of the mechanisms involved in the pharmacological activity of these compounds. In
Zhi-Wei Chen et al.
Nucleic acids research, 42(18), 11560-11569 (2014-09-25)
Human single-strand (ss) DNA binding proteins 1 (hSSB1) has been shown to participate in DNA damage response and maintenance of genome stability by regulating the initiation of ATM-dependent signaling. ATM phosphorylates hSSB1 and prevents hSSB1 from ubiquitin-proteasome-mediated degradation. However, the
Retsu Mitsui et al.
Pflugers Archiv : European journal of physiology, 467(6), 1327-1342 (2014-07-30)
Venules in the stomach may have intrinsic properties for maintaining active microcirculation drainage even during gastric filling. Properties of spontaneous and nerve-mediated activity of submucosal venules in the rat stomach were investigated. Changes in vasodiameter and intracellular Ca(2+) in venular
Kathrin Arnhard et al.
Analytical and bioanalytical chemistry, 407(2), 405-414 (2014-11-05)
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become an indispensable analytical technique in clinical and forensic toxicology for detection and identification of potentially toxic or harmful compounds. Particularly, non-target LC-MS/MS assays enable extensive and universal screening requested in systematic toxicological analysis.
Máté Virágh et al.
Protein & cell, 6(7), 518-528 (2015-05-23)
Small, cysteine-rich, highly stable antifungal proteins secreted by filamentous Ascomycetes have great potential for the development of novel antifungal strategies. However, their practical application is still limited due to their not fully clarified mode of action. The aim of this
Guangjian Fan et al.
Nature communications, 6, 8450-8450 (2015-10-07)
Centrosome amplification is frequent in cancer, but the underlying mechanisms remain unclear. Here we report that disruption of the Kruppel-like factor 14 (KLF14) gene in mice causes centrosome amplification, aneuploidy and spontaneous tumorigenesis. Molecularly, KLF14 functions as a transcriptional repressor
Naomi L Kruhlak et al.
Toxicology mechanisms and methods, 18(2-3), 217-227 (2008-01-01)
ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifested in preclinical studies and may delay or prevent the development
Luís M Magalhães et al.
Talanta, 147, 460-467 (2015-11-26)
Spent coffee grounds (SCGs) are a great source of bioactive compounds with interest to pharmaceutical and cosmetic industries. Phenolics and methylxanthines are the main health related compounds present in SCG samples. Content estimation of these compounds in SCGs is of
Khrystyna Yu Sukhanova et al.
Pharmacological reports : PR, 66(3), 363-372 (2014-06-07)
ATP is one of the principal sympathetic neurotransmitters which contracts vascular smooth muscle cells (SMCs) via activation of ionotropic P2X receptors (P2XRs). We have recently demonstrated that contraction of the guinea pig small mesenteric arteries evoked by stimulation of P2XRs
Md Maniruzzaman Manir et al.
Bioorganic & medicinal chemistry, 20(7), 2376-2381 (2012-03-02)
Four new quercetin acylglycosides, designated camelliquercetisides A-D, quercetin 3-O-[α-L-arabinopyranosyl(1→3)][2-O″-(E)-p-coumaroyl][β-D-glucopyranosyl(1→3)-α-L-rhamnopyranosyl(1→6)]-β-D-glucoside (17), quercetin 3-O-[2-O″-(E)-p-coumaroyl][β-D-glucopyranosyl(1→3)-α-L-rhamnopyranosyl(1→6)]-β-D-glucoside (18), quercetin 3-O-[α-L-arabinopyranosyl(1→3)][2-O″-(E)-p-coumaroyl][α-L-rhamnopyranosyl(1→6)]-β-d-glucoside (19), and quercetin 3-O-[2-O″-(E)-p-coumaroyl][α-L-rhamnopyranosyl(1→6)]-β-D-glucoside (20), together with caffeine and known catechins, and flavonoids (1-16) were isolated from the leaves of Camellia sinensis. Their structures were
Dieter Zimmer et al.
Bioanalysis, 5(6), 711-719 (2013-03-15)
The scientifically and logistically best way of application of the internal standard (IS) in the analysis of dried blood spots (DBS) analysis is still a matter of debate and investigation. Most commonly the IS is added in the solvent used
Kate A Bartel et al.
Sleep medicine reviews, 21, 72-85 (2014-12-03)
Teenagers need sufficient sleep to function well daily, yet consolidated evidence advising which factors protect, or harm, adolescents' sleep is lacking. Forty-one studies, published between 2003 and February, 2014, were meta-analysed. Mean weighted r values were calculated to better understand
Margarida Galhetas et al.
Journal of colloid and interface science, 433, 94-103 (2014-08-13)
The high carbon contents and low toxicity levels of chars from coal and pine gasification provide an incentive to consider their use as precursors of porous carbons obtained by chemical activation with K2CO3. Given the chars characteristics, previous demineralization and
Pragalathan Naidoo et al.
Pharmacological reports : PR, 66(4), 585-593 (2014-06-21)
The aim of the present study was to develop an alternative non-obese non-genetic rat model of type 2 diabetes (T2D). Six-week-old male SD rats were randomly divided into six groups, namely: Normal Control (NC), Diabetic Control (DBC), Caffeine 5mg/kg BW+STZ
Satoko Kimura et al.
Life sciences, 127, 32-38 (2015-03-10)
Ventilatory disturbance is a fatal side-effect of opioid analgesics. Separation of analgesia from ventilatory depression is important for therapeutic use of opioids. It has been suggested that opioid-induced ventilatory depression results from a decrease in adenosine 3',5'-cyclic monophosphate content in
Joo Hyun Baik et al.
Journal of the science of food and agriculture, 95(11), 2337-2344 (2014-10-14)
Green tea is a dietary source of bioactive compounds for human health. Enzymatic treatments induce the bioconversion of bioactive components, which can improve biological activities. In this study, we investigated the effect of simultaneous treatment with tannase and Rapidase on
Dong-Mei Wu et al.
Toxicology and applied pharmacology, 285(2), 89-97 (2015-04-15)
Steroid hormones synthesized from cholesterol in the fetal adrenal are crucial for fetal development. We have observed the inhibited fetal adrenal corticosterone synthesis and increased intrauterine growth retardation (IUGR) rate in rats under prenatal caffeine ingestion. The aim of this
Ricardo Mora-Rodríguez et al.
Journal of science and medicine in sport, 18(3), 338-342 (2014-05-13)
To determine whether the ergogenic effects of caffeine ingestion on neuromuscular performance are similar when ingestion takes place in the morning and in the afternoon. Double blind, cross-over, randomized, placebo controlled design. Thirteen resistance-trained males carried out bench press and
Chuanhai Cao et al.
Journal of Alzheimer's disease : JAD, 42(3), 973-984 (2014-07-16)
The purpose of this study was to investigate the potential therapeutic qualities of Δ9-tetrahydrocannabinol (THC) with respect to slowing or halting the hallmark characteristics of Alzheimer's disease. N2a-variant amyloid-β protein precursor (AβPP) cells were incubated with THC and assayed for
Mirosława Zydroń et al.
Journal of separation science, 27(14), 1166-1172 (2004-11-13)
An SPE method, using RP18 phases, for the simultaneous extraction of caffeine, theobromine, theophylline, paraxanthine, 1-methylxanthine, 3-methylxanthine, 7-methylxanthine, 1-methyluric acid, 1,3-dimethyluric acid, 1,7-dimethyluric acid, and 1,3,7-trimethyluric acid from urine has been developed. Besides a gradient HPLC system for the analysis
Timing of caffeine therapy in very low birth weight infants.
Barbara Schmidt et al.
The Journal of pediatrics, 164(5), 957-958 (2014-03-19)
Ziv Lifshitz et al.
Infection and immunity, 82(9), 3740-3752 (2014-06-25)
Coxiella burnetii, the causative agent of Q fever, is a human intracellular pathogen that utilizes the Icm/Dot type IVB secretion system to translocate effector proteins into host cells. To identify novel C. burnetii effectors, we applied a machine-learning approach to
George P Lahm et al.
Bioorganic & medicinal chemistry letters, 17(22), 6274-6279 (2007-09-22)
Rynaxypyr is a highly potent and selective activator of insect ryanodine receptors with exceptional activity on a broad range of Lepidoptera. A strong correlation between insecticidal activity and ryanodine receptor activation is observed along with selective activity against insect over
Marzanna Kurzawa et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 995-996, 101-106 (2015-06-09)
Antioxidant activity, total phenolics content and selected phytochemicals (alkaloids and andrographolides) were determined in Andrographis paniculata and in dietary supplements containing this plant. Antioxidant activity was measured by FRAP, CUPRAC and DPPH procedures and ranged from 503.36 to 6164.09μmol TE/100g
Orthostatic hypotension in the elderly: diagnosis and treatment
Gupta V and Lipsitz LA
The American Journal of Medicine, 120(10), 841-847 (2007)
Jie Ping et al.
Toxicology, 321, 53-61 (2014-04-11)
Prenatal caffeine ingestion is one of the risk factors for intrauterine growth retardation (IUGR). Adrenal plays a pivotal role, mainly through steroidogenesis, in the regulation of intrauterine homeostasis and in fetal development and maturation. We have shown that prenatal caffeine
Mashaalah Zarejousheghani et al.
Journal of chromatography. A, 1411, 23-33 (2015-08-11)
Acesulfame is a known indicator that is used to identify the introduction of domestic wastewater into water systems. It is negatively charged and highly water-soluble at environmental pH values. In this study, a molecularly imprinted polymer (MIP) was synthesized for
S Shah et al.
The European respiratory journal, 27(5), 1066-1068 (2006-05-19)
Hepatic veno-occlusive disease is defined as nonthrombotic fibrous obliterative endophlebitis of small centrilobular hepatic venules. Clinically, patients present with elevated liver enzymes and a triad of jaundice, hepatomegaly and ascites. Although reported as a complication of other solid organ and
Luiz Augusto da Silva et al.
Pharmaceutical biology, 52(8), 956-960 (2014-03-08)
Caffeine can stimulate insulin secretion by attenuating hyperglycemia in diabetes models with significant reduction of pancreatic functional β cells. Knowledge of these mechanisms could contribute to new strategies for treating diabetes. This study evaluated the effects of caffeine and physical
Brian A Mc Ardle et al.
Circulation. Cardiovascular imaging, 7(6), 930-937 (2014-09-04)
Cardiac allograft vasculopathy is a key prognostic determinant after heart transplant. Detection and risk stratification of patients with cardiac allograft vasculopathy are problematic. Positron emission tomography using rubidium-82 allows quantification of absolute myocardial blood flow and may have utility for
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