Merck
Search Within
Applied Filters:
Keyword:'b9285'
Showing 1-30 of 299 results for "

b9285

" within Papers
Israel Muñoz-Velasco et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 61(9), 680-689 (2013-06-19)
Seminiferous tubules in mammals have histological arrangements defined by the associations between somatic cells and germ cells. The processes of DNA synthesis in meiotic and mitotic cells have different features that are not easily distinguishable through morphological means. In order
Yinan Wang et al.
The Journal of experimental medicine, 211(5), 841-856 (2014-04-09)
The duration of antibody production by long-lived plasma cells varies with the type of immunization, but the basis for these differences is unknown. We demonstrate that plasma cells formed in response to the same immunogen engage distinct survival programs depending
Endan Li et al.
Experimental neurology, 252, 75-84 (2013-12-04)
Ghrelin has been shown to regulate neurogenesis in the hippocampus. The aim of this study was to investigate the possible influence of ghrelin on cell proliferation and neuroblast formation in the subventricular zone (SVZ) and rostral migratory system (RMS) and
Histological, cellular and behavioral assessments of stroke outcomes after photothrombosis-induced ischemia in adult mice
Li H, et al.
BMC Neuroscience, 15(1), 1-13 (2014)
Tina Napso et al.
International journal of oncology, 44(6), 1971-1979 (2014-04-15)
Zebularine, a potent DNA methyltransferase inhibitor, is potentially able to influence gene regulation and thereby alters cell behavior. This study illustrates the effect of zebularine on human squamous cell carcinoma (SCC-9 and SCC-25) in vitro. The results indicated that zebularine significantly
Elisa Cappellini et al.
Life sciences, 131, 30-36 (2015-04-22)
Eps8 is an actin-binding protein which has been proposed as a regulator of cancer cell motility and invasion. However, nothing much is known about its contribution to the invasive properties of endothelial cells (ECs), and more generally to angiogenesis. Expression
Kang-Ho Choi et al.
Molecular brain, 8, 9-9 (2015-03-13)
The antioxidant properties of alpha-lipoic acid (aLA) correlate with its ability to promote neuroproliferation. However, there have been no comprehensive studies examining the neurorestorative effects of aLA administration after the onset of ischemia. The middle cerebral artery (MCA) of adult
Costanza Ferrari Bardile et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(19), 9622-9627 (2019-04-25)
White matter abnormalities are a nearly universal pathological feature of neurodegenerative disorders including Huntington disease (HD). A long-held assumption is that this white matter pathology is simply a secondary outcome of the progressive neuronal loss that manifests with advancing disease.
Meng Zhao et al.
Cell reports, 26(3), 652-669 (2019-01-17)
Regulation of hematopoietic stem cells (HSCs) by bone marrow (BM) niches has been extensively studied; however, whether and how HSC subpopulations are distinctively regulated by BM niches remain unclear. Here, we functionally distinguished reserve HSCs (rHSCs) from primed HSCs (pHSCs)
Ricardo Laranjeiro et al.
Development (Cambridge, England), 141(13), 2644-2656 (2014-06-14)
The circadian clock is known to regulate a wide range of physiological and cellular processes, yet remarkably little is known about its role during embryo development. Zebrafish offer a unique opportunity to explore this issue, not only because a great
Andreas Lambertz et al.
The Journal of surgical research, 192(2), 312-316 (2014-08-26)
The systemic palliative chemotherapy of locally extended gastrointestinal and hepatobiliary tumors is associated with a considerable burden for the patient. The aim of this project was to develop a new drug release system to improve the local stent therapy in
Yu Ri Kim et al.
Behavioural brain research, 287, 294-303 (2015-04-08)
We investigated the question of whether an animal model of post-stroke depression in ischemic stroke can be developed by additional chronic mild stress (CMS) procedures. Behavioral and histopathological analysis was performed for examination of the depressive disorders in CMS, left
Denise A Zannino et al.
Developmental biology, 390(2), 247-260 (2014-03-19)
Proper functioning of the vertebrate central nervous system requires the precise positioning of many neuronal cell types. This positioning is established during early embryogenesis when gene regulatory networks pattern the neural tube along its anteroposterior and dorsoventral axes. Dorsoventral patterning
Dongbo Shi et al.
Development (Cambridge, England), 141(23), 4558-4568 (2014-11-20)
The oviduct is an important organ in reproduction where fertilization occurs, and through which the fertilized eggs are carried to the uterus in mammals. This organ is highly polarized, where the epithelium forms longitudinal folds along the ovary-uterus axis, and
Willscott E Naugler
PloS one, 9(5), e97426-e97426 (2014-05-21)
Many signals governing liver regeneration (LR) following 2/3 partial hepatectomy (PH) are recognized, but the primary signal(s) remains unknown. The aim of the study was to confirm that the remnant liver after PH lacks capacity to secrete the BA pool
Zhanchun Li et al.
International journal of molecular sciences, 16(2), 2294-2306 (2015-01-27)
F-box and WD repeat domain-containing 7 (FBXW7) is a potent tumor suppressor in human cancers including breast cancer, colorectal cancer, gastric cancer and hepatocellular carcinoma. In this study, we found that the expressions of FBXW7 protein and mRNA levels in
Youngshik Choe et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(16), 6766-6775 (2013-04-19)
To understand life-long neurogenesis in the dentate gyrus (DG), characterizing dentate neural stem cells and the signals controlling their development are crucial. In the present study, we show that bone morphogenic protein (Bmp) signaling is a critical regulator of embryonic
Tao Yin et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 70, 90-96 (2015-03-18)
ATPase inhibitory factor 1 (IF1) has recently been considered as a potential oncogene in human cancers. Recently, increasing evidences have shown that IF1 is overexpressed in human cancers and promotes tumor growth and metastasis. In this study, we found that
Panagiotis Ntziachristos et al.
Nature, 514(7523), 513-517 (2014-08-19)
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy with a dismal overall prognosis, including a relapse rate of up to 25%, mainly because of the lack of non-cytotoxic targeted therapy options. Drugs that target the function of key epigenetic
Chen-Yan Ma et al.
Development (Cambridge, England), 141(24), 4697-4709 (2014-12-04)
The balance between self-renewal and differentiation of adult neural stem cells (aNSCs) is essential for the maintenance of the aNSC reservoir and the continuous supply of new neurons, but how this balance is fine-tuned in the adult brain is not
Tanuja Rajah et al.
PloS one, 10(4), e0123711-e0123711 (2015-04-29)
The cathepsin B inhibitor, benzyloxycarbonyl-phenylalanine-alanine-fluoromethyl ketone (z-FA-FMK) readily inhibits anti-CD3-induced human T cell proliferation, whereas the analogue benzyloxycarbonyl-phenylalanine-alanine-diazomethyl ketone (z-FA-DMK) had no effect. In contrast, benzyloxycarbonyl-phenylalanine-alanine-chloromethyl ketone (z-FA-CMK) was toxic. The inhibition of T cell proliferation mediated by z-FA-FMK requires
Jonathan T McGuane et al.
The American journal of pathology, 185(5), 1409-1422 (2015-04-25)
The factors that predispose one-tenth of reproductive-aged women to endometriosis are poorly understood. We determined that genetic deficiency in transforming growth factor β1 impairs endometriosis-like lesion growth in mice. Given that seminal plasma is an abundant source of transforming growth
Ya Xie et al.
Oncology letters, 8(5), 1993-1999 (2014-10-08)
Obesity, diabetes and insulin resistance are marked risk factors that promote the development of type I endometrial cancer. Previous studies have demonstrated that insulin-like growth factor 1 (IGF-1) and IGF-2 promote cell proliferation in endometrial cancer cells, while metformin reverses
R Vivian Allahyari et al.
Scientific reports, 9(1), 565-565 (2019-01-27)
Following injury to the central nervous system, astrocytes perform critical and complex functions that both promote and antagonize neural repair. Understanding the molecular signaling pathways that coordinate their diverse functional properties is key to developing effective therapeutic strategies. In the
Ghayda Mirzaa et al.
Nature genetics, 46(5), 510-515 (2014-04-08)
Activating mutations in genes encoding phosphatidylinositol 3-kinase (PI3K)-AKT pathway components cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH, OMIM 603387). Here we report that individuals with MPPH lacking upstream PI3K-AKT pathway mutations carry de novo mutations in CCND2 (encoding cyclin D2) that are clustered
Jonathan Vosper et al.
Oncotarget, 6(5), 2889-2902 (2015-01-22)
Statins, such as lovastatin, can induce a cell cycle arrest in the G1 phase. This robust antiproliferative activity remains intact in many cancer cells that are deficient in cell cycle checkpoints and leads to an increased expression of CDK inhibitor
Maria Svensson et al.
Hippocampus, 25(11), 1351-1360 (2015-04-09)
Strategies employing different techniques to inhibit or stimulate neurogenesis have implicated a role for adult-born neurons in the therapeutic effect of antidepressant drugs, as well as a role in memory formation. Electroconvulsive seizures (ECS), an animal model of electroconvulsive therapy
K Ito et al.
Oncogene, 33(14), 1862-1871 (2013-04-30)
Cell proliferation and differentiation are closely coupled. However, we previously showed that overexpression of cyclin-dependent kinase (Cdk6) blocks chondrocyte differentiation without affecting cell-cycle progression in vitro. To investigate whether Cdk6 inhibits chondrocyte differentiation in vivo, we generated chondrocyte-specific Cdk6 transgenic
Sabine M Brouxhon et al.
Molecular carcinogenesis, 53(11), 893-906 (2013-06-19)
Recent literature suggests that sEcad exerts pro-oncogenic effects, possibly acting as a ligand for the human epidermal growth factor family. Here we show that sEcad is a novel candidate protein for drug targeting since it is increased in human and
Sianne Oktaria et al.
Physics in medicine and biology, 60(20), 7847-7859 (2015-09-26)
Despite the use of multimodal treatments incorporating surgery, chemotherapy and radiotherapy, local control of gliomas remains a major challenge. The potential of a new treatment approach called indirect radio-chemo-beta therapy using the synergy created by combining methotrexate (MTX) with bromodeoxyuridine
Page 1 of 10
Page 1 of 10