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Shao Fu et al.
AAPS PharmSciTech, 15(5), 1228-1237 (2014-06-04)
The purpose of this study is to characterize the inter-grade and inter-batch variability of sodium alginate used in the formulation of matrix tablets. Four different grades and three batches of one grade of sodium alginate were used to prepare matrix
Jonathan S Jahr et al.
American journal of therapeutics, 20(2), 189-199 (2013-03-08)
Hospitals are subject to more economic pressures than ever before. On the one hand, cost containment or cost reduction is paramount, particularly in relation to costly branded pharmaceuticals. On the other hand, quality measures and value-based reimbursement penalizes poor patient
Arthur E Kümmerle et al.
Bioorganic & medicinal chemistry letters, 19(17), 4963-4966 (2009-08-04)
A set of six azaheterocycles were designed as conformationally-constrained N-acylhydrazones and tested as analgesics.
Agnieszka Karbownik et al.
European journal of drug metabolism and pharmacokinetics, 40(2), 163-170 (2014-03-29)
The study aimed to examine the effect of sunitinib on the plasma exposure of intravenous paracetamol and its major metabolite, paracetamol glucuronide. Both drugs share metabolic pathways in the liver, and the drug interactions between sunitinib and paracetamol administered in
Sheng Yu et al.
Journal of the American Medical Informatics Association : JAMIA, 22(5), 993-1000 (2015-05-02)
Analysis of narrative (text) data from electronic health records (EHRs) can improve population-scale phenotyping for clinical and genetic research. Currently, selection of text features for phenotyping algorithms is slow and laborious, requiring extensive and iterative involvement by domain experts. This
Valentina Onnis et al.
Journal of medicinal chemistry, 53(5), 2286-2298 (2010-02-11)
Fatty acid amide hydrolase (FAAH) is the key hydrolytic enzyme for the endogenous cannabinoid receptor ligand anandamide. The synthesis and evaluation for their FAAH inhibitory activities of a series of 18 paracetamol esters are described. Structure-activity relationship studies indicated that
M Cheelo et al.
Archives of disease in childhood, 100(1), 81-89 (2014-11-28)
While paracetamol exposure in pregnancy and early infancy has been associated with asthma, it remains unclear whether this is confounded by respiratory tract infections, which have been suggested as an alternative explanation. We undertook a systematic review and meta-analysis of
Rodney N Nishimoto
Anesthesia progress, 61(3), 99-102 (2014-09-06)
This was judged to be the first place winning submission for the American Dental Society of Anesthesiology Student Essay Award. Acetaminophen is an old drug that is now available in an intravenous formulation. Its advantages and disadvantages are reviewed, including
Elias Begas et al.
Journal of chromatographic science, 52(7), 590-595 (2013-06-27)
Methotrexate (MTX) is a dihydrofolate reductase inhibitor that is used for the treatment of tumors and autoimmune diseases. Several automated binding assays are used in clinical practice and numerous chromatographic methods have been developed toward higher specificity and sensitivity. In
Hans-Christoph Diener et al.
The journal of headache and pain, 15, 76-76 (2014-11-20)
Most patients with episodic tension-type headache treat headache episodes with over-the-counter medication. Combination analgesics containing caffeine may be more effective and as well tolerated as monotherapy. The aim of this study was to evaluate the efficacy of the combination of
Kit Baley et al.
AANA journal, 82(1), 53-64 (2014-03-25)
Pediatric surgical patients are a population at risk of inadequate pain management. The American Society of Anesthesiologists' 2012 Practice Guidelines for Acute Pain Management in the Perioperative Setting recommend a multimodal approach as the most effective way to prevent and
Christopher J Derry et al.
The Cochrane database of systematic reviews, 6(6), CD010210-CD010210 (2013-06-25)
Combining two different analgesics in fixed doses in a single tablet can provide better pain relief than either drug alone in acute pain. This appears to be broadly true across a range of different drug combinations, in postoperative pain and
David R Janz et al.
Critical care medicine, 43(3), 534-541 (2014-12-05)
This trial evaluated the efficacy of acetaminophen in reducing oxidative injury, as measured by plasma F2-isoprostanes, in adult patients with severe sepsis and detectable plasma cell-free hemoglobin. Single-center, randomized, double-blind, placebo-controlled phase II trial. Medical ICU in a tertiary, academic
Harley T Syyong et al.
American journal of respiratory cell and molecular biology, 52(3), 304-314 (2014-07-24)
A characteristic feature of asthma is exaggerated airway narrowing, termed airway hyper-responsiveness (AHR) due to contraction of airway smooth muscle (ASM). Although smooth muscle (SM)-specific asthma susceptibility genes have been identified, it is not known whether asthmatic ASM is phenotypically
Tong Wang et al.
The Analyst, 140(15), 5176-5183 (2015-06-03)
Cobalt nanoparticle modified indium tin oxide (CoNP/ITO) electrodes fabricated by ion implantation were applied for the detection of reduced glutathione (GSH). The CoNP/ITO electrode was characterized by scanning electron microscopy (SEM), energy dispersive X-ray (EDX) detector and X-ray photoelectron spectroscopy
Eda Ozcelik et al.
Pharmacognosy magazine, 10(Suppl 2), S217-S224 (2014-07-06)
Liver diseases have become a major problem of the worldwide. More than 50% of all cases of liver failure can be attributed to drugs. Among these, acetaminophen is the most common cause. The aim of this study was to investigate
Romain Hernu et al.
Intensive care medicine, 41(8), 1402-1410 (2015-06-17)
Physicians play an important role in strategies to control health care spending. Being aware of the cost of prescriptions is surely the first step to incorporating cost-consciousness into medical practice. The aim of this study was to evaluate current intensivists'
Huan Yang et al.
The Journal of experimental medicine, 212(1), 5-14 (2015-01-07)
Innate immune receptors for pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) orchestrate inflammatory responses to infection and injury. Secreted by activated immune cells or passively released by damaged cells, HMGB1 is subjected to redox modification that distinctly influences its
Mahmoud Mohammadi et al.
Indian pediatrics, 40(12), 1183-1186 (2004-01-15)
The present study was done to explore the relationship between the cerebrospinal fluid (CSF) glucose concentration, body temperature, seizure duration, and acetaminophen administration. Retrospective record review of 117 consecutive febrile convulsive infants aging 3 to 18 months admitted to Bahrami
[Effectiveness of analgesic combinations in the self-medication].
Eve C A Morgenstern et al.
MMW Fortschritte der Medizin, 155(9), 49-51 (2013-08-21)
When is research clinical advice? Interpreting an exploratory study of paracetamol overdose.
Geoffrey K Isbister et al.
Clinical toxicology (Philadelphia, Pa.), 51(10), 1242-1242 (2013-11-14)
Krishna Devarakonda et al.
Journal of pain research, 8, 647-656 (2015-10-29)
To characterize the single-dose and steady-state pharmacokinetics (PK) of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (IR/ER HB/APAP), IR HB/ibuprofen, and IR tramadol HCl/APAP. In this single-center, open-label, randomized, four-period crossover study, healthy participants received four treatments under fasted conditions: 1) a single
Luciano Rezende Vilela et al.
Mediators of inflammation, 2015, 523418-523418 (2015-05-23)
Cocaine is a commonly abused illicit drug that causes significant morbidity and mortality. The most severe and common complications are seizures, ischemic strokes, myocardial infarction, and acute liver injury. Here, we demonstrated that acute cocaine intoxication promoted seizure along with
Hitoshi Maeda et al.
The Journal of pharmacology and experimental therapeutics, 352(2), 244-257 (2014-11-16)
Since reactive oxygen species (ROS) derived from Kupffer cells (KC), especially CD68(+) KC, play a key role in the induction of hepatic oxidative stress and injuries, we developed a polythiolated- and mannosylated human serum albumin (SH-Man-HSA), which functions as a
Constantine J Karvellas et al.
Critical care medicine, 42(5), 1157-1167 (2013-12-20)
To determine if intracranial pressure monitor placement in patients with acute liver failure is associated with significant clinical outcomes. Retrospective multicenter cohort study. Academic liver transplant centers comprising the U.S. Acute Liver Failure Study Group. Adult critically ill patients with
Clive Gentry et al.
Scientific reports, 5, 12771-12771 (2015-08-01)
Acetaminophen (APAP) is an effective antipyretic and one of the most commonly used analgesic drugs. Unlike antipyretic non-steroidal anti-inflammatory drugs, APAP elicits hypothermia in addition to its antipyretic effect. Here we have examined the mechanisms responsible for the hypothermic activity
Mayu Kakehi et al.
Toxicological sciences : an official journal of the Society of Toxicology, 147(2), 360-369 (2015-07-17)
There are various interspecies differences in xenobiotic-metabolizing enzymes. It is known that cats show slow glucuronidation of drugs such as acetaminophen and strong side effects due to the UGT1A6 pseudogene. Recently, the UGT1A6 pseudogene was found in the Northern elephant
Lisette Charbonnier et al.
PloS one, 10(7), e0131727-e0131727 (2015-07-15)
We are continuously exposed to food and during the day we make many food choices. These choices play an important role in the regulation of food intake and thereby in weight management. Therefore, it is important to obtain more insight
U Eranka Illangakoon et al.
International journal of pharmaceutics, 477(1-2), 369-379 (2014-12-03)
A series of polyvinylpyrrolidone fibers loaded with paracetamol (PCM) and caffeine (CAF) was fabricated by electrospinning and explored as potential oral fast-dissolving films. The fibers take the form of uniform cylinders with smooth surfaces, and contain the drugs in the
Takafumi Tomida et al.
Toxicology letters, 236(1), 16-24 (2015-05-03)
The utility of HepaRG cells as an in vitro cell-based assay system for assessing drug-induced liver injury (DILI) risk was investigated. Seventeen DILI-positive and 15 DILI-negative drugs were selected for the assay. HepaRG cells were treated with each drug for
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