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Xianxi Zhang et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 67(3-4), 1135-1138 (2006-11-14)
Chemical shifts of some reduced symmetry peripheral fused-ring-substituted phthalocyanines, namely Zn3B1N, Zncis2B2N, Zntrans2B2N, Zn1B3N and Zn3B0N, have been calculated at density functional B3LYP level using the gauge-independent atomic orbital (GIAO) method. The geometries were optimized using the 6-31G(d) basis set
Xin Wang et al.
Nature communications, 5, 5776-5776 (2014-12-17)
In their natural habitat, bacteria are consumed by bacterivorous nematodes; however, they are not simply passive preys. Here we report a defensive mechanism used by certain bacteria to mobilize nematode-trapping fungi to kill nematodes. These bacteria release urea, which triggers
Abbas M Walji et al.
ChemMedChem, 10(2), 245-252 (2014-12-04)
Developing new antiretroviral therapies for HIV-1 infection with potential for less frequent dosing represents an important goal within drug discovery. Herein, we present the discovery of ethyl (1-((4-((4-fluorobenzyl)carbamoyl)-1-methyl-2-(2-(5-methyl- 1,3,4-oxadiazole-2-carboxamido)propan-2-yl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)ethyl) carbonate (MK-8970), a highly optimized prodrug of raltegravir (Isentress). Raltegravir is a
B E Johansson et al.
Physics in medicine and biology, 44(9), 2161-2170 (1999-09-24)
The general collection efficiency in the dielectric liquids iso-octane (CaH18; 2-2-4 trimethylpentane) and tetramethylsilane (Si(CH3)4), used as sensitive media in a thimble liquid ionization chamber (LIC) with a liquid layer thickness of 1 mm, has been studied. Measurements were made
Yin-Chih Fu et al.
Acta biomaterialia, 10(11), 4583-4596 (2014-07-23)
Nanoparticles (NP) that target bone tissue were developed using PLGA-PEG (poly(lactic-co-glycolic acid)-polyethylene glycol) diblock copolymers and bone-targeting moieties based on aspartic acid, (Asp)(n(1,3)). These NP are expected to enable the transport of hydrophobic drugs. The molecular structures were examined by
V N Shankar et al.
Archives of biochemistry and biophysics, 387(2), 297-306 (2001-05-24)
The active vitamin D analog, 19-nor-1alpha,25-dihydroxyvitamin D2 (19-nor-1alpha,25-(OH)2D2), has a similar structure to the natural vitamin D hormone, 1a,25-dihydroxyvitamin D3 (1alpha,25-(OH)2D3), but lacks the C10-19 methylene group and possesses an ergosterol/ vitamin D2 rather than a cholesterol/vitamin D3 side chain.
B Johansson et al.
Physics in medicine and biology, 42(10), 1929-1938 (1997-11-19)
The general collection efficiency in pulsed radiation was studied for isooctane (C8H18) and tetramethylsilane (Si(CH3)4). These two liquids were used as sensitive media in a parallel-plate liquid ionization chamber with a 1 mm sensitive layer. Measurements were carried out using
Raphael Hoareau et al.
Journal of labelled compounds & radiopharmaceuticals, 57(13), 715-720 (2014-10-29)
We have investigated the use of cyclic sulfamidates as precursors to yield secondary amines as building blocks for subsequent reaction with carboxylic acids and acyl chlorides. The preparation of the protonated form of [(18)F]-N-(2-fluoro-ethyl)-N-methylamine from the corresponding cyclic sulfamidate proceeded
Quan Liu et al.
Journal of agricultural and food chemistry, 62(34), 8555-8561 (2014-08-05)
Weed infestation has been known to cause considerable reductions in crop yields, thereby hindering sustainable agriculture. Many plants in genus Euphorbia affect neighboring plants and other organisms by releasing chemicals into the environment. In view of the serious threat of
Seong Su Hong et al.
Fitoterapia, 99, 347-351 (2014-12-03)
The ethanolic extract of the needles of Pinus thunbergii was found to suppress antigen mediated degranulation of rat basophilic leukemia (RBL-2H3) cells. A new neolignan glycoside, named pinusthunbergiside A (1), as well as six known neolignan glycosides (2-7) were isolated
Xijuan Chen et al.
The Science of the total environment, 505, 39-46 (2014-10-13)
Aerobic degradation experiments of Triclosan were performed in activated sludge to identify possible transformation products for this compound. During 7 days, the formation of biotransformation products such as 2,4-Dichlorophenol, 4-Chlorocatechol, 5-Hydroxy-Triclosan and other Monohydroxy-Triclosan derivatives as well as Dihydroxy-Triclosan-derivatives were
Anastasia De Luca et al.
Oncotarget, 6(6), 4126-4143 (2015-01-18)
We designed and synthesized two novel nitrobenzoxadiazole (NBD) analogues of the anticancer agent 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (NBDHEX). The new compounds, namely MC3165 and MC3181, bear one and two oxygen atoms within the hydroxy-containing alkyl chain at the C4 position of the NBD
Heath D Watts et al.
The journal of physical chemistry. B, 115(9), 1958-1970 (2011-02-16)
Coniferyl alcohol is a monomeric building block of lignin, the second most abundant biopolymer. During lignification, the monomer forms a variety of linkages through free radical additions. A large NMR database has been constructed that reports the (1)H and (13)C
August Andersson et al.
FEBS letters, 545(2-3), 139-143 (2003-06-14)
The interaction between the peptide hormone motilin and bicelles has been investigated by pulsed field gradient-nuclear magnetic resonance methods and by the use of paramagnetic probes. Diffusion coefficients were measured for motilin, the phospholipids with and without motilin, and for
Ahmed Kamal et al.
Bioorganic chemistry, 59, 23-30 (2015-02-11)
A new series of C8-linked dithiocarbamate/piperazine bridged pyrrolo[2,1-c][1,4]benzodiazepine conjugates (5a-c, 6a,b) have been synthesized and evaluated for their cytotoxic potential and DNA-binding ability. The representative conjugates 5a and 5b have been screened for their cytotoxicity against a panel of 60
Kazutaka Shibatomi et al.
Chemistry, an Asian journal, 3(8-9), 1581-1584 (2008-06-21)
The Lewis acid catalyzed bromination of aromatic side chains was achieved efficiently by using 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) as the bromination reagent under mild conditions. Zirconium(IV) chloride showed the highest catalytic activity for this benzylic bromination. It was revealed that the present
Steroidal glycosides from the underground parts of Dracaena thalioides and their cytotoxic activity.
Liying Tang et al.
Phytochemistry, 107, 102-110 (2014-08-26)
Six spirostanol glycosides (1-6) and 12 known compounds (7-18) were isolated from the underground parts of Dracaena thalioides (Agavaceae). Their structures were determined by spectroscopic analysis, including 2D NMR spectroscopic data, and chemical transformations. The isolated compounds were evaluated for
Alicia J Sawdon et al.
Colloids and surfaces. B, Biointerfaces, 122, 738-745 (2014-09-07)
Polymeric prodrug micelles for delivery of acyclovir (ACV) were synthesized. First, ACV was used directly to initiate ring-opening polymerization of ɛ-caprolactone to form ACV-polycaprolactone (ACV-PCL). Through conjugation of hydrophobic ACV-PCL with hydrophilic methoxy poly(ethylene glycol) (MPEG) or chitosan, polymeric micelles
Thuy Nguyen et al.
Bioorganic & medicinal chemistry, 23(9), 2195-2203 (2015-03-24)
A series of substituted 1H-indole-2-carboxamides structurally related to compounds Org27569 (1), Org29647 (2) and Org27759 (3) were synthesized and evaluated for CB1 allosteric modulating activity in calcium mobilization assays. Structure-activity relationship studies showed that the modulation potency of this series
Elise Ivarsen et al.
Journal of AOAC International, 97(5), 1282-1290 (2015-04-24)
Clostridium perfringens is the causative agent of necrotic enteritis leading to significant losses in the poultry industry. Dichloromethane and n-hexane extracts of aerial parts of Artemisia annua (Asteraceae) exhibited activity against C. perfringens with minimum inhibitory concentrations (MIC) of 185
Nicolás Ubero-Pascal et al.
Microscopy research and technique, 68(5), 264-271 (2005-11-30)
Hexamethyldisilizane (HMDS) and tetramethylsilane are organic compounds that are volatile at ambient temperature and which can therefore be used for air-drying biological samples for SEM studies. The techniques using these compounds provide results that are comparable with those obtained by
Sandeep Gawaskar et al.
Bioorganic & medicinal chemistry, 22(23), 6638-6646 (2014-12-03)
Due to their beneficial side effect profile, NMDA receptor antagonists interacting selectively with the allosteric ifenprodil binding site of the GluN2B subunit are of major interest for the treatment of neurological and neurodegenerative disorders. A series of benzo[7]annulen-7-amines 6 was
Jannatul Firdous et al.
Acta biomaterialia, 10(11), 4606-4617 (2014-08-12)
Respiratory syncytial virus (RSV) is one of the most common causes of viral deaths in infants worldwide, yet no effective vaccines are available. Here, we report an osmotically active polysaccharide-based polysorbitol transporter (PST) prepared from sorbitol diacrylate and low-molecular-weight polyethylenimine
Shi-Ben Wang et al.
European journal of medicinal chemistry, 84, 574-583 (2014-07-26)
A series of new purines containing triazole and other heterocycle substituents was synthesized and evaluated for their preliminary anticonvulsant activity and neurotoxicity by using the maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ) and rotarod neurotoxicity (TOX) tests. Among the compounds studied
Monica Olivella et al.
Archiv der Pharmazie, 348(1), 68-80 (2014-11-22)
New nitrosopyrimidines were synthesized and evaluated as potential antibacterial agents. Different compounds structurally related with 4,6-bis(alkyl or arylamino)-5-nitrosopyrimidines were evaluated. Some of these nitrosopyrimidines displayed significant antibacterial activity against human pathogenic bacteria. Among them compounds 1c, 2a-c, and 9a-c exhibited
Esther Tejeda-Montes et al.
Biomaterials, 35(29), 8339-8347 (2014-07-06)
The search for alternative therapies to improve bone regeneration continues to be a major challenge for the medical community. Here we report on the enhanced mineralization, osteogenesis, and in vivo bone regeneration properties of a bioactive elastin-like recombinamer (ELR) membrane.
Amel Bouzabata et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 75, 166-172 (2014-12-03)
In Algeria, Myrtus communis L. is distributed throughout the Tell Atlas and the coastal regions of Algiers and Constantine. The leaves are used in respiratory disorders, diarrhea and hemorrhoids. The aims of this work were to evaluate the antifungal and
Philippe C Gros et al.
Organic & biomolecular chemistry, 4(23), 4331-4335 (2006-11-15)
The first regioselective C-4 lithiation of (S)-nicotine has been realized using TMSCH2Li as basic reagent in toluene. The reaction proceeded under mild conditions with a small excess of electrophile. The 4-chloro derivative was subsequently metallated at C-5 with the same
Zhifeng Li et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 988, 45-52 (2015-03-10)
An ultra performance liquid chromatography (UHPLC) coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (ESI-Q-TOF-MS/MS) was used in the structural determination of natural compounds in Gastrodia elata. A total of 64 compounds were identified or tentatively characterized. The strategy used
Costyl N Njiojob et al.
Journal of medicinal chemistry, 58(6), 2845-2854 (2015-02-26)
The success of near-infrared (NIR) fluorescence to be employed for intraoperative imaging relies on the ability to develop a highly stable, NIR fluorescent, nontoxic, biocompatible, and highly excreted compound that retains a reactive functionality for conjugation to a cancer-recognizing peptide.
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