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82762

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Weilin Guo et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 988, 157-165 (2015-03-18)
Intranasal delivery is emerging as a promising alternative for oral or intravenous administration of central nervous system (CNS) drugs, such as pramipexole which is widely used for the treatment of Parkinson's disease. To evaluate the effectiveness of intranasal delivery of...
Cristina Pavan et al.
Particle and fibre toxicology, 11, 76-76 (2014-12-20)
The hemolytic activity of inhaled particles such as silica has been widely investigated in the past and represents a usual toxicological endpoint to characterize particle reactivity despite the fact that red blood cells (RBCs) are not involved in the pathogenesis...
Anne Scheffler et al.
Toxicology letters, 234(2), 81-91 (2015-02-24)
After consumption of red clover-based dietary supplements, plasma concentrations of the isoflavone irilone (IRI) equal that of the well-investigated daidzein. Since some isoflavones are genotoxic, the potential of IRI to induce mutations was investigated. Gene mutations were determined by hypoxanthine-guanine...
Magdalena Poplawska et al.
Journal of pharmaceutical and biomedical analysis, 94, 45-53 (2014-02-18)
The new compound - flibanserin - begun to appear as a synthetic adulterant in counterfeit herbal supplements used to stimulate women sexual drive. It was detected in two samples submitted to the Polish National Medicines Institute for analysis. The second...
Rocchina Sabia et al.
Journal of chromatography. A, 1363, 144-149 (2014-08-21)
Diazepam and the structurally related 1,4-benzodiazepin-2-ones tetrazepam, prazepam and flunitrazepam are chiral molecules because they adopt a ground state conformation featuring a non-planar seven membered ring devoid of any reflection-symmetry element. The two conformational enantiomers of this class of benzodiazepines...
Bernhard Kluger et al.
Analytical chemistry, 86(23), 11533-11537 (2014-11-06)
An untargeted metabolomics workflow for the detection of metabolites derived from endogenous or exogenous tracer substances is presented. To this end, a recently developed stable isotope-assisted LC-HRMS-based metabolomics workflow for the global annotation of biological samples has been further developed...
Anastasia Koltsakidou et al.
Journal of chromatography. A, 1377, 46-54 (2014-12-30)
In the present report, a simple and cost-effective method for the determination of twelve US EPA priority polycyclic aromatic hydrocarbons (PAHs) in honey samples after salting-assisted liquid-liquid extraction and UHPLC with fluorescence detection is proposed. The sample treatment is based...
Nadège Minois et al.
PloS one, 9(7), e102435-e102435 (2014-07-11)
Spermidine is a natural polyamine involved in many important cellular functions, whose supplementation in food or water increases life span and stress resistance in several model organisms. In this work, we expand spermidine's range of age-related beneficial effects by demonstrating...
Yiming Zhang et al.
Journal of immunotoxicology, 12(1), 81-91 (2014-05-16)
Innate defenses against environmental particulate exposures can become deficient when physiological background of the organism is unbalanced. Even those exposures considered innocuous may then become harmful. For example, one of the important inherent risks of pregnancy is increased inflammatory responsiveness...
Ming Lei et al.
Journal of pharmaceutical sciences, 104(3), 995-1004 (2014-12-30)
The biopharmaceutical industry increasingly demands thorough characterization of protein conformation and conformational dynamics to ensure product quality and consistency. Here, we present a chromatography-based method that is able to characterize protein conformation and conformational dynamics at peptide level resolution in...
Sachine Yoshida et al.
Journal of neuroscience methods, 243, 63-67 (2015-02-04)
Mouse pups are invaluable model animals for understanding the molecular and neural basis underlying behavioral development. Stereotaxic operations with anesthetic control are useful tools in systems neuroscience. However, there are no commercially available anesthetic or stereotaxic devices for mouse pups....
W Leconet et al.
Oncogene, 33(47), 5405-5414 (2013-11-19)
AXL receptor tyrosine kinase (RTK) is implicated in proliferation and invasion of many cancers, particularly in pancreatic ductal adenocarcinoma (PDAC), for which new therapeutic options are urgently required. We investigated whether inhibition of AXL activity by specific monoclonal antibodies (mAbs)...
Mattia Gasperotti et al.
Talanta, 128, 221-230 (2014-07-26)
An increasing number of studies have concerned the profiling of polyphenol microbial metabolites, especially in urine or plasma, but only a few have regarded their accurate quantification. This study reports on a new ultra-performance liquid chromatography tandem mass spectrometry method...
M M Parrilla Vázquez et al.
Journal of chromatography. A, 1356, 1-9 (2014-07-06)
Two dispersive liquid-liquid microextraction (DLLME) approaches including temperature-controlled ionic liquid dispersive liquid-liquid microextraction (TCIL-DLLME) and ultrasound-assisted ionic liquid dispersive liquid-liquid microextraction (US-IL-DLLME) were compared for the extraction of six benzoylurea insecticides (diflubenzuron, triflumuron, hexaflumuron, teflubenzuron, lufenuron and flufenoxuron) from wastewater...
Yu Bon Man et al.
The Science of the total environment, 505, 261-268 (2014-12-03)
This study was to investigate removal efficiencies and profiles of 14 polybrominated diphenyl ether (PBDE) congeners by two different types of sewage treatment work (STW) in Hong Kong: Stonecutters Island STW (SCISTW) which uses chemically enhanced primary treatment (CEPT) process...
Farhadul Islam et al.
Phytotherapy research : PTR, 29(4), 573-581 (2015-01-15)
Anticancer activities of p-menth-1-ene-4,7-diol (EC-1) isolated from Eucalyptus camaldulensis Dhnh. were studied on Ehrlich ascites carcinoma (EAC) cells by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. Anticancer activities also analyzed in EAC-bearing mice by assessment of cancer growth inhibition, changes in...
Mingxia Liu et al.
The Journal of biological chemistry, 290(12), 7861-7870 (2015-01-30)
Apolipoprotein M (apoM), a plasma sphingosine 1-phosphate (S1P) carrier, associates with plasma HDL via its uncleaved signal peptide. Hepatocyte-specific apoM overexpression in mice stimulates formation of both larger nascent HDL in hepatocytes and larger mature apoM/S1P-enriched HDL particles in plasma...
Codrin Andrei et al.
PloS one, 9(10), e109836-e109836 (2014-10-30)
A substantial and stable increase of the current density Jsc of ruthenium (Ru) dye sensitized solar cells (DSC) of up to 16.18% and of the power efficiency of up to 25.5% is demonstrated in this article via plasmonic enhancement. The...
Junzhi Wang et al.
Nature communications, 5, 5449-5449 (2014-11-12)
Maser is an acronym for microwave amplification by stimulated emission of radiation; in astronomy mega-masers are masers in galaxies that are ≥ 10(6) times more luminous than typical galactic maser sources. Observational studies of mega-masers can help us to understand...
Malcolm E Tessensohn et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 16(1), 160-168 (2014-11-25)
Voltammetric experiments with 9,10-anthraquinone and 1,4-benzoquinone performed under controlled moisture conditions indicate that the hydrogen-bond strengths of alcohols in aprotic organic solvents can be differentiated by the electrochemical parameter ΔEp (red) =|Ep (red(1)) -Ep (red(2)) |, which is the potential...
X Yang et al.
Journal of veterinary pharmacology and therapeutics, 38(1), 55-64 (2014-11-08)
A multi-compartment physiologically based pharmacokinetic (PBPK) model to describe the disposition of cyadox (CYX) and its metabolite quinoxaline-2-carboxylic acid (QCA) after a single oral administration was developed in rats (200 mg/kg b.w. of CYX). Considering interspecies differences in physiology and...
V Cijo George et al.
Journal of food science and technology, 52(4), 2328-2335 (2015-04-02)
Annona muricata is a naturally occurring edible plant with wide array of therapeutic potentials. In India, it has a long history of traditional use in treating various ailments. The present investigation was carried out to characterize the phytochemicals present in...
A Kaufmann et al.
Analytica chimica acta, 862, 41-52 (2015-02-16)
An ultra-high performance liquid chromatography based method, coupled to high resolution mass spectrometry (UHPLC-HRMS), was developed to permit the detection and quantification of various nitrofuran and chloramphenicol residues in a number of animal based food products. This method is based...
Jun-Feng Li et al.
PloS one, 9(4), e95095-e95095 (2014-04-17)
Accurate estimation of hepatic necroinflammation caused by chronic hepatitis C (CHC) is crucial for prediction of prognosis and design of therapeutic strategy, which is particularly true for CHC patients with normal alanine aminotransferase (ALT) level. Recent studies have shown that...
Anne Bayer et al.
Environmental science and pollution research international, 21(18), 10830-10839 (2014-06-06)
Pharmaceuticals and other anthropogenic trace contaminants reach wastewaters and are often not satisfactorily eliminated in sewage treatment plants. These contaminants and/or their degradation products may reach surface waters, thus influencing aquatic life. In this study, the behavior of five different...
Romain Simon et al.
Journal of pharmaceutical and biomedical analysis, 94, 84-91 (2014-02-21)
Glomeruli play a major role in the kidney function since they are involved in primary urine formation. It is then crucial to dispose of methods to monitor glomerular injury, especially in drug development. In this context, quantification of podocin could...
Aashish Soni et al.
Nucleic acids research, 42(10), 6380-6392 (2014-04-22)
In mammalian cells, ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) are repaired in all phases of the cell cycle predominantly by classical, DNA-PK-dependent nonhomologous end joining (D-NHEJ). Homologous recombination repair (HRR) is functional during the S- and G2-phases, when a...
Yasmin M Vasquez et al.
Molecular endocrinology (Baltimore, Md.), 29(3), 421-433 (2015-01-15)
The forkhead box O1A (FOXO1) is an early-induced target of the protein kinase A pathway during the decidualization of human endometrial stromal cells (HESCs). In this study we identified the cistrome and transcriptome of FOXO1 and its role as a...
Manjusha Saxena et al.
Pakistan journal of biological sciences : PJBS, 16(24), 1971-1977 (2014-02-13)
Tridax procumbens L., Asteraceae, has been extensively used for various ailments in the Ayurvedic system of medicine. Previous studies have revealed remarkable phytoconstituents from Tridax procumbens L. with significant antioxidant activity. The aim of the present study is to measure...
David M G Anderson et al.
Analytical and bioanalytical chemistry, 407(8), 2311-2320 (2015-02-11)
MALDI imaging requires careful sample preparation to obtain reliable, high-quality images of small molecules, peptides, lipids, and proteins across tissue sections. Poor crystal formation, delocalization of analytes, and inadequate tissue adherence can affect the quality, reliability, and spatial resolution of...
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