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Dae-Jung Kang et al.
Biotechnology letters, 37(9), 1895-1904 (2015-05-23)
Resting cells of Pseudonocardia sp. KCTC 1029BP were used for the bioconversion of vitamin D3 to calcifediol which is widely used to treat osteomalacia and is industrially produced by chemical synthesis. To obtain the maximum bioconversion yield of calcifediol by
Zaidoon Al-Jaderi et al.
Toxins, 7(11), 4730-4744 (2015-11-19)
Experimental autoimmune encephalomyelitis (EAE) is a CD4⁺ T cell mediated inflammatory demyelinating disease that is induced in mice by administration of peptides derived from myelin proteins. We developed EAE in SJL mice by administration of PLP139-151 peptide. The effect of
Mei Ding et al.
Experimental and therapeutic medicine, 8(6), 1737-1744 (2014-11-06)
Xuezhikang (XZK), an extract of red yeast rice, has been widely used for the management of hyperlipidemia and coronary heart disease (CHD); however, the effects of XZK treatment on kidney injury have not yet been fully identified. The aim of
Jianfeng Zhang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(3), 1219-1229 (2015-03-15)
Transplantation of bone-marrow derived stem/progenitor cells has an established therapeutic effect on cardiac muscle repair after injury. However, the exact mechanism that underlies this phenomenon is not completely understood. Here we transplanted mesenchymal stem cells (MSCs), a major population from
Umon Agata et al.
Journal of nutritional science and vitaminology, 59(1), 29-36 (2013-03-29)
Low calcium (Ca) intake is the one of risk factors for both bone loss and medial elastocalcinosis in an estrogen deficiency state. To examine the effect of different amounts of Ca intake on the relationship between bone mass alteration and
Bao-Xin Liu et al.
Medicine, 94(25), e991-e991 (2015-06-25)
Osteoporosis and related fragility fractures represent a serious and global public health problem. To evaluate whether the modified eighth section of Eight-section Brocade (MESE) exercise could improve the symptom and indexes associated with osteoporosis in postmenopausal women. Guangzhou and Liuzhou
A G Fuchs et al.
Journal of helminthology, 88(4), 459-467 (2013-06-08)
Bisphosphonates have been proposed as pharmacological agents against parasite and cancer cell growth. The effect of these compounds on helminthic cell viability and acellular compartment morphology, however, has not yet been studied. The effects of different types of bisphosphonates, namely
Melissa Jensen et al.
Journal of pediatric gastroenterology and nutrition, 61(2), 187-189 (2015-02-05)
Oral high-dose repletion vitamin D therapy, also known as stoss therapy, can be effective in the treatment of nutritional vitamin D deficiency rickets in infants and young children without liver disease and in patients with cystic fibrosis. There is no
Isa Gabriela de Medeiros Cavalcante et al.
Experimental gerontology, 66, 10-16 (2015-04-02)
This study aimed to evaluate the effect of vitamin D3 megadose supplementation and influence of BsmI polymorphism in the VDR gene on the inflammatory profile and oxidative stress in elderly women with vitamin D deficiency. A double blind, randomized, placebo-controlled
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated
P De Groote et al.
Cell death and differentiation, 22(6), 1012-1024 (2014-11-29)
Receptor-interacting protein kinase 4 (RIPK4)-deficient mice have epidermal defects and fusion of all external orifices. These are similar to Bartsocas-Papas syndrome and popliteal pterygium syndrome (PPS) in humans, for which causative mutations have been documented in the RIPK4 and IRF6
Li-hong Gao et al.
Acta pharmacologica Sinica, 36(9), 1065-1073 (2015-08-19)
To investigate the effects of calcium and vitamin D supplementation on bone turnover marker levels, muscle strength and quality of life in postmenopausal Chinese women. A total of 485 healthy postmenopausal Chinese women (63.44±5.04 years) were enrolled in this open-label
Jing Zhang et al.
Calcified tissue international, 96(1), 80-87 (2014-11-25)
Thyroid hormones (THs) including thyroxine (T4) and triiodothyronine (T3) play critical roles in bone remodeling. However, the role and mechanism of THs in vascular calcification (VC) have been unclear. To explore the pathophysiological roles of T3 on VC, we investigated
Z H Ren et al.
Journal of animal science, 93(1), 127-134 (2014-11-19)
The aim of this study was to evaluate the effects of antibacterial peptide (ABP) sufficiency on cellular immune functions by determining the spleen cell cycle and apoptosis, peripheral blood T cell subsets, and T cell proliferation function in weaned piglets.
K L Little et al.
Journal of animal science, 93(3), 1284-1297 (2015-05-29)
The objectives of this experiment were to determine growth performance, visceral mass differences, carcass characteristics, fresh meat quality, and carcass cutability of growing-finishing pigs fed diets containing high-protein canola meal (CM-HP) or conventional canola meal (CM-CV). Seven dietary treatments were
Umon Agata et al.
Journal of nutritional science and vitaminology, 61(5), 391-399 (2015-12-08)
Reduced estrogen secretion and low calcium (Ca) intake are risk factors for bone loss and arterial calcification in female rodents. To evaluate the effects of Ca intake at different amounts on bone mass changes and arterial calcification, 8-wk-old female Wistar
Ahmed Alsaqr et al.
AAPS PharmSciTech, 16(4), 963-972 (2015-01-23)
Transdermal delivery of therapeutic amounts of vitamin D3 is proposed to overcome its variable oral bioavailability, especially for people who suffer from fat malabsorption. The main challenge for this delivery route is to overcome the barrier properties of skin, especially
Fuyuko Koibuchi et al.
Biological & pharmaceutical bulletin, 37(7), 1241-1247 (2014-07-06)
Emerging evidence indicates that stress hormone glucocorticoids (GC) are an important modulator of brain development and function. To investigate whether GCs modulate neurosteroid biosynthesis in neural cells, we studied the effects of GCs on steroidogenic gene expression in human glioma
Anders Burild et al.
Scandinavian journal of clinical and laboratory investigation, 74(5), 418-423 (2014-04-23)
Serum 25-hydroxy-vitamin D is the established biomarker of vitamin D status although serum concentrations of vitamin D and 24,25-dihydroxyvitamin D may also be of interest to understand the in vivo kinetics of serum 25-hydroxyvitamin D. An LC-MS/MS method was developed
Upasana Banerjee et al.
Bioorganic & medicinal chemistry letters, 22(3), 1330-1334 (2012-01-10)
A structure-activity relationship study focusing on the A-ring of vitamin D3 (VD3) was undertaken to elucidate its role in inhibiting the Hedgehog pathway and in mediating anti-cancer effects. Analogues resulting from simple functional group substitution at 3' position of VD3
Alexander Holderied et al.
Laboratory investigation; a journal of technical methods and pathology, 95(3), 273-282 (2014-12-23)
The metabolic and hemodynamic alterations in diabetes activate podocytes to increase extracellular matrix (ECM) production, leading to thickening of the glomerular basement membrane (GBM). We hypothesized that diabetes would activate parietal epithelial cells (PECs) in a similar manner and cause
Lara Coelho et al.
Nutrition journal, 14, 81-81 (2015-08-19)
HIV infection and antiretroviral therapy (ART) may create unique risk factors for vitamin D insufficiency, including alterations of vitamin D metabolism by ART. We prospectively compared demographic and clinical parameters between vitamin D sufficient and insufficient HIV-infected (HIV+) adults, and
Nicholas A McKeag et al.
JACC. Heart failure, 2(3), 308-317 (2014-06-24)
This study sought to investigate the effect of a multiple micronutrient supplement on left ventricular ejection fraction (LVEF) in patients with heart failure. Observational studies suggest that patients with heart failure have reduced intake and lower concentrations of a number
Ming Kong et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(9), G883-G893 (2014-09-13)
Vitamin D deficiency (VDD) or insufficiency is recognized for its association with nonalcoholic steatohepatitis (NASH), whereas the underlying mechanism remains unknown. Using animal models, we found that vitamin D deficiency promoted the high-fat diet (HFD)-initiated simple steatosis into typical NASH
Bing Li et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(2), 433-440 (2015-01-24)
Transplantation of mesenchymal stem cells (MSCs) has therapeutic effects on various diseases, while its effect on developing cirrhosis as well as the underlying mechanism remained largely unknown. Twenty C57BL/6 mice were randomly separated into 2 groups of ten each. One
Mariana Costa Silva et al.
Bone, 81, 338-342 (2015-07-26)
Oral supplements are important to prevent and treat vitamin D deficiency. Despite the growing number of prescriptions, vitamin D's absorptive mechanisms are not clearly elucidated. By evaluating the effect of ezetimibe on vitamin D absorption, we aim to determine if
Joan Hui Juan Lim et al.
The Journal of infectious diseases, 212(4), 635-644 (2015-01-24)
Vitamin D level is linked to susceptibility to infections, but its relevance in candidemia is unknown. We aimed to investigate the in vivo sequelae of vitamin D3 supplementation in systemic Candida infection. Implicating the role of vitamin D in Candida
Maria J Ramalho et al.
Beilstein journal of nanotechnology, 6, 1306-1318 (2015-07-23)
Poly(lactic-co-glycolic acid) (PLGA) nanoparticles were studied as drug delivery vehicles for calcitriol, the active form of vitamin D3. In vitro effects of calcitriol encapsulated in PLGA nanoparticles were evaluated with respect to free calcitriol on human pancreatic cell lines, S2-013
Bassem Refaat et al.
Journal of experimental & clinical cancer research : CR, 34, 71-71 (2015-07-25)
Vitamin D3 and its analogues have recently been shown to enhance the anti-tumour effects of 5- Fluorouracil (5-FU) both in vitro and in xenograft mouse model of colon cancer. This study measured the potential mechanism(s) by which vitamin D3 could
Yuko Murakami et al.
Microbes and infection, 16(2), 114-122 (2013-11-02)
Using a high-throughput screening system involving HCV JFH-1-Huh 7.5.1 cells, we determined that the ligands of class II nuclear receptors, retinoids and rexinoids inhibit HCV infection. Retinoids, ligands of retinoic acid receptor (RAR), and rexinoids, ligands of retinoid X receptor
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