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Shoko Sawano et al.
Animal science journal = Nihon chikusan Gakkaiho, 85(12), 994-1000 (2014-09-05)
Regenerative intramuscular motor-innervation is thought to reside in the spatiotemporal expression of axon-guidance molecules. Our previous studies showed that resident myogenic stem cells, satellite cells, up-regulate a secreted neural-chemorepellent semaphorin 3A (Sema3A) during the early-differentiation period, in response to hepatocyte
Kenji Sakota et al.
The journal of physical chemistry. B, 119(32), 10334-10340 (2015-07-29)
Macromolecular crowding alters many biological processes ranging from protein folding and enzyme reactions in vivo to the precipitation and crystallization of proteins in vitro. Herein, we have investigated the effect of specific monovalent Hofmeister salts (NaH2PO4, NaF, NaCl, NaClO4, and
José Patricio Casanova et al.
Behavioural brain research, 296, 70-77 (2015-09-01)
A growing body of evidence suggests that learned fear may be related to the function of the interoceptive insular cortex. Using an auditory fear conditioning paradigm in rats, we show that the inactivation of the posterior insular cortex (pIC), the
Monika E Dolega et al.
Biomaterials, 52, 347-357 (2015-03-31)
3D culture systems are a valuable tool for modeling morphogenesis and carcinogenesis of epithelial tissue in a structurally appropriate context. We present a novel approach for 3D cell culture based on a flow-focusing microfluidic system that encapsulates epithelial cells in
Juhyung Lee et al.
Biochemical and biophysical research communications, 447(1), 121-127 (2014-04-08)
Cyclin-dependent kinase 5 (CDK5), a member of atypical serine/threonine cyclin-dependent kinase family, plays a crucial role in pathophysiology of neurodegenerative disorders. Its kinase activity and substrate specificity are regulated by several independent pathways including binding with its activator, phosphorylation and
M Nurhasan et al.
Prostaglandins, leukotrienes, and essential fatty acids, 96, 57-61 (2015-03-11)
Fatty acid analysis requires standardized collection and storage of samples, which can be a challenge under field conditions. This study describes the effect of storage temperature on fatty acid composition in two sets of whole blood samples collected from 66
Raffaella Alò et al.
Brain research bulletin, 118, 65-77 (2015-09-27)
Recent evidences indicate that cerebral neurotrophic factors like vascular endothelial growth factor plus signaling pathways of the glutamatergic neuroreceptor system (L-Glu) are determinant modulators of depression-like states. In the present study, the type of interaction(s) exerted by the AMPAergic antagonist
Jiyoung Kim et al.
Macromolecular bioscience, 15(8), 1081-1090 (2015-04-02)
The accurate diagnosis and proper therapy for cancer are essential to improve the success rate of cancer treatment. Here, we demonstrated that the vitamin Bc -bearing hydrophilic photosensitizer conjugate folic acid-polyethylene glycol-pheophorbideA (FA-PEG-PheoA) has been synthesized for the intracellular diagnosis
F I Al-Jenoobi et al.
Drug research, 65(6), 312-316 (2014-07-06)
The present study was conducted to investigate the effect of commonly used herb Commiphora myrrha on the pharmacokinetic profile of theophylline (narrow therapeutic index drug) in rabbits. In the experimental groups, theophylline (16 mg/kg) was given orally to the rabbits.
Jeffrey H Walton et al.
Biochemical and biophysical research communications, 463(4), 479-482 (2015-05-23)
Dynamic Contrast Enhanced (DCE) MRI is increasingly being used to assess changes in capillary permeability. Most quantitative techniques used to measure capillary permeability are based on the Fick equation that requires measurement of signal reflecting both plasma and tissue concentrations
Watcharaporn Kamjumphol et al.
The American journal of tropical medicine and hygiene, 93(5), 1058-1065 (2015-09-02)
The resilience of Burkholderia pseudomallei, the causative agent of melioidosis, was evaluated in control soil microcosms and in soil microcosms containing NaCl or FeSO4 at 30°C. Iron (Fe(II)) promoted the growth of B. pseudomallei during the 30-day observation, contrary to
Carolien Grammen et al.
International journal of pharmaceutics, 475(1-2), 238-244 (2014-09-02)
The purpose of this work was to design and evaluate a vaginal film delivery system for UAMC01398, a novel non-nucleoside reverse transcriptase inhibitor currently under investigation for use as an anti-HIV microbicide. UAMC01398 (1mg) films consisting of hydroxypropylmethylcellulose (HPMC) and
Yitong J Zhang et al.
Journal of pharmaceutical sciences, 104(5), 1815-1824 (2015-03-11)
Artemisinin (ART), a well-known antimalaria drug, also exhibits anticancer activities. We previously reported a group of novel dimeric artemisinin piperazine conjugates (ADPs) possessing pH-dependent aqueous solubility and a proof-of-concept lipid nanoparticle formulation based on natural egg phosphatidylcholine (EPC). EPC may
Alexander S McLawhorn et al.
Clinical orthopaedics and related research, 473(10), 3183-3189 (2015-06-07)
The enhanced posterior soft tissue repair has reduced the frequency of dislocation after primary THA performed through the posterolateral approach. However, the long-term integrity of the repair is unknown and could influence surgeon choice regarding surgical technique and THA approach.
Le Ngoc Tran et al.
Journal of chromatography. A, 1356, 289-293 (2014-07-20)
An organic-inorganic silica/zirconia hybrid monolithic capillary column was prepared by sol-gel process in a fused-silica capillary by using triethoxysilylpropylcarbamate (TEOSPC) derivative of clindamycin phosphate (CLIP) as a chiral selector. A sol solution consisting of 6 × 10(-3)M of polyethylene glycol
Kam H To et al.
Journal of bacteriology, 196(21), 3683-3689 (2014-08-06)
For most phages, holins control the timing of host lysis. During the morphogenesis period of the infection cycle, canonical holins accumulate harmlessly in the cytoplasmic membrane until they suddenly trigger to form lethal lesions called holes. The holes can be
Christian Schmidl et al.
Blood, 123(17), e68-e78 (2014-03-29)
CD4(+)CD25(+)FOXP3(+) human regulatory T cells (Tregs) are essential for self-tolerance and immune homeostasis. Here, we describe the promoterome of CD4(+)CD25(high)CD45RA(+) naïve and CD4(+)CD25(high)CD45RA(-) memory Tregs and their CD25(-) conventional T-cell (Tconv) counterparts both before and after in vitro expansion by
Amy V Gore et al.
The journal of trauma and acute care surgery, 79(1), 48-52 (2015-06-20)
Rodent lungs undergo full histologic recovery within 1 week following unilateral lung contusion (LC). However, when LC is followed by hemorrhagic shock (HS), healing is impaired. We hypothesize that the intravenous administration of mesenchymal stem cells (MSCs) in animals undergoing
Jodee L Johnson et al.
Pancreas, 44(1), 144-151 (2014-09-23)
This study aimed to evaluate the ability of luteolin (Lut), gemcitabine (Gem), and their combination (Lut + Gem) to prevent the growth of pancreatic tumors in vivo. The antitumor effect of intraperitoneally administered Lut, Gem, and Lut + Gem was
B Álvarez et al.
Developmental and comparative immunology, 51(2), 238-250 (2015-04-22)
A cDNA clone encoding a 380 a-a type 1 transmembrane protein with homology to human Siglec-3/CD33 was obtained from a swine small intestine library. An analysis of protein sequence identified two immunoglobulin-like domains, a transmembrane region, and a carboxi-terminal tail
Christina L Gardner et al.
Journal of virology, 87(15), 8582-8590 (2013-05-31)
Recently, we compared amino acid sequences of the E2 glycoprotein of natural North American eastern equine encephalitis virus (NA-EEEV) isolates and demonstrated that naturally circulating viruses interact with heparan sulfate (HS) and that this interaction contributes to the extreme neurovirulence
Wei Tao et al.
Advanced healthcare materials, 4(8), 1203-1214 (2015-03-25)
A novel blended nanoparticle (NP) system for the delivery of anticancer drugs and its surprisingly high efficacy for cancer chemotherapy by blending a targeting polymer folic acid-poly(ethylene glycol)-b-poly(lactide-co-glycolide) (FA-PEG-b-PLGA) and a miscible structurally similar polymer D-α-tocopheryl polyethylene glycol 1000 succinate-poly(lactide-co-glycolide)
Mehran Mehri
Poultry science, 93(7), 1862-1867 (2014-05-09)
The optimization algorithm of a model may have significant effects on the final optimal values of nutrient requirements in poultry enterprises. In poultry nutrition, the optimal values of dietary essential nutrients are very important for feed formulation to optimize profit
Jie Zhang et al.
The Biochemical journal, 461(3), 497-508 (2014-05-13)
Lantibiotics are ribosomally synthesized antimicrobial peptides containing unusual amino acids. As promising alternatives to conventional antibiotics, they have a high potential for alleviating the problem of emergent antibiotic resistance, with possible applications in many industries that have antibacterial demand. Bovicin
Fatma Elzahraa Abdelrahman et al.
International journal of pharmaceutics, 490(1-2), 281-291 (2015-06-01)
The aim of this study was to enhance the risperidone delivery to the brain through the transnasal route via optimization of cubosomal gel. Cubosomes were prepared using glycerol mono-oleate (GMO), Pluronic F127 (PF127) and Tween 80 (T80). The prepared formulae
Albert T Hsu et al.
Shock (Augusta, Ga.), 44(2), 128-136 (2015-05-27)
Primed neutrophils that are capable of releasing matrix metalloproteinases (MMPs) into the circulation are thought to play a significant role in the pathophysiology of acute respiratory distress syndrome (ARDS). We hypothesized that direct measurement of plasma MMP-9 activity may be
Andreas Reisch et al.
ACS nano, 9(5), 5104-5116 (2015-04-22)
Ultrasmall polymer nanoparticles are rapidly gaining importance as nanocarriers for drugs and contrast agents. Here, a straightforward modular approach to efficiently loaded and stable sub-20-nm polymer particles is developed. In order to obtain ultrasmall polymer nanoparticles, we investigated the influence
Esmail Riahi et al.
Neurobiology of learning and memory, 119, 93-101 (2015-02-15)
The hippocampus receives sparse orexinergic innervation from the lateral hypothalamus and expresses a high level of orexin receptor. The function of orexin receptor in the regulation of hippocampal neural activity has never been investigated. In this study, in vivo single
Gina L Lonati et al.
The Journal of experimental biology, 218(Pt 16), 2620-2630 (2015-08-21)
Understanding toothed whale (odontocete) diving gas dynamics is important given the recent atypical mass strandings of odontocetes (particularly beaked whales) associated with mid-frequency naval sonar. Some stranded whales have exhibited gas emboli (pathologies resembling decompression sickness) in their specialized intramandibular
Chih-Kuang Chuang et al.
Orphanet journal of rare diseases, 9, 135-135 (2014-09-03)
The identification of acid mucopolysaccharide by the liquid chromatography/tandem mass spectrometry method (LC-MS/MS) of the predominant disaccharide units of glycosaminoglycans (GAGs) (chondroitin sulfate, CS; dermatan sulfate, DS; heparan sulfate, HS) after methanolysis is validated and applicable for mucopolysaccharidosis (MPS) type
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