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Souichi Nakashima et al.
Bioorganic & medicinal chemistry, 18(6), 2337-2345 (2010-03-02)
The methanolic extract from the whole plants of Anastatica hierochuntica, an Egyptian herbal medicine, was found to inhibit melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. Among the constituents isolated, anastatin A, silybin A, isosilybins A and B, eriodictyol, luteolin
Hyunshun Shin et al.
Bioorganic & medicinal chemistry, 15(7), 2617-2623 (2007-02-14)
The first committed step in lipid A biosynthesis is catalyzed by uridine diphosphate-(3-O-(R-3-hydroxymyristoyl))-N-acetylglucosamine deacetylase (LpxC), a zinc-dependent deacetylase, and inhibitors of LpxC may be useful in the development of antibacterial agents targeting a broad spectrum of Gram-negative bacteria. Here, we
Chika Tateda et al.
The Plant cell, 26(10), 4171-4187 (2014-10-16)
In Arabidopsis thaliana, responses to pathogen-associated molecular patterns (PAMPs) are mediated by cell surface pattern recognition receptors (PRRs) and include the accumulation of reactive oxygen species, callose deposition in the cell wall, and the generation of the signal molecule salicylic
A Hage et al.
Applied microbiology and biotechnology, 52(6), 834-838 (2000-01-05)
Ligninolytic basidiomycetes were screened for their ability to reduce aryl acids to the corresponding aldehydes and alcohols. Seven fungal strains converted p-anisic acid in high molar yields to the reduced products. The white-rot fungus Bjerkandera sp. strain BOS55 was one
M Wessels et al.
Journal of natural products, 64(12), 1556-1558 (2002-01-05)
From the hydrophilic extract of the ascidian Polycarpa aurata three new compounds, N-(4-methoxybenzoyl)-N'-methylguanidine (1), butyl 2-(4-methoxyphenyl)-2-oxoacetate (2), and 2-(4-methoxyphenyl)-N-methyl-2-oxoacetamide (3), together with the known compounds methyl 2-(4-methoxyphenyl)-2-oxoacetate (4) and 4-methoxybenzoic acid were isolated. The structures of all isolates were determined
Wojciech Ostrowski et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 21-27 (2014-07-27)
Liquid chromatography coupled to mass spectrometry (MS) with electrospray ionization (ESI) is one of analytical techniques to obtain accurate results of low molecular weight aromatic compounds in biological samples of different origin. The interpretations of mass spectra of these aromatic
J Lynas et al.
The Biochemical journal, 325 ( Pt 3), 609-616 (1997-08-01)
A series of novel synthetic peptides, containing a C-terminal beta-amino alcohol linked to p-methoxybenzoic acid via an ester linkage, have been prepared and tested as inhibitors against typical members of the serine protease family. For example, the sequences Ac-Val-Pro-NH-CH-(CH2-C6H5)-CH2O-CO-C6H4-OCH3 (I)
P Xiao et al.
Hippocampus, 1(4), 373-380 (1991-10-01)
Aniracetam reversibly increased synaptic responses mediated by the AMPA but not the NMDA subclass of glutamate receptors in hippocampus and was considerably more potent than structurally similar nootropics. The drug had greater effects on field excitatory postsynaptic potentials (EPSPs) in
U Karlson et al.
Journal of bacteriology, 175(5), 1467-1474 (1993-03-01)
A red-pigmented coryneform bacterium, identified as Rhodococcus rhodochrous strain 116, that grew on 2-ethoxyphenol and 4-methoxybenzoate as sole carbon and energy sources was isolated. Phylogenetic analysis based on the 16S rDNA sequences indicates that the strain clusters more closely to
K Sekar et al.
Journal of molecular biology, 333(2), 367-376 (2003-10-08)
Phospholipase A2 catalyses the hydrolysis of the ester bond of 3-sn-phosphoglycerides. Here, we report the crystal structures of the free and anisic acid-bound triple mutant (K53,56,120M) of bovine pancreatic phospholipase A2. In the bound triple mutant structure, the small organic
Patricia Ferreira et al.
The Journal of biological chemistry, 284(37), 24840-24847 (2009-07-04)
Aryl-alcohol oxidase (AAO) is a FAD-containing enzyme in the GMC (glucose-methanol-choline oxidase) family of oxidoreductases. AAO participates in fungal degradation of lignin, a process of high ecological and biotechnological relevance, by providing the hydrogen peroxide required by ligninolytic peroxidases. In
S Pauillac et al.
Journal of immunological methods, 220(1-2), 105-114 (1998-12-05)
A rapid, simple and low cost procedure for preparing minute amount of hapten-protein conjugates was developed using 4-acetyl benzoic acid (ABA) and two other closely related small chromophoric haptens. The amide bond-generating mixed anhydride method of Erlanger was modified to
Georgios Papandreou et al.
Journal of pharmaceutical and biomedical analysis, 56(3), 615-622 (2011-07-12)
Simultaneous determination of aniracetam and its related impurities (2-pyrrolidinone, p-anisic acid, 4-p-anisamidobutyric acid and (p-anisoyl)-4-methyl-2-pyrrolidinone) was accomplished in the bulk drug and in a tablet formulation using a high performance liquid chromatographic method with UV detection. Separation was achieved on
H G Ibrahim et al.
Pharmaceutical research, 10(5), 737-742 (1993-05-01)
We investigated the effects of increased concentrations of the solutes, salicylic acid, benzoic acid, and o-, m-, and p-methoxy benzoic acids, on the anisotropic properties of a liquid crystal solvent. The lamellar liquid crystal was composed of 37% polyoxyethylene (20)
Jean J K Bankeu et al.
Journal of natural products, 74(6), 1370-1378 (2011-05-31)
Phytochemical investigation of the figs of Ficus mucuso led to the isolation of three new isoflavone dimer derivatives, mucusisoflavones A-C (1-3), together with 16 known compounds. Some of the isolates were tested in vitro for their inhibitory properties toward β-glucuronidase
Antony Gomes et al.
The Indian journal of medical research, 136(1), 40-45 (2012-08-14)
Phospholipase A2 (PLA2 ) is one of the major constituents of krait venom associated with several pathophysiological actions like myotoxicity, cardiotoxicity, neurotoxicity, etc. As there was no specific antiserum available against Bungarus fasciatus venom, this study was done with synthetic
P Martin et al.
Journal of pharmaceutical and biomedical analysis, 17(6-7), 1093-1100 (1999-01-12)
The extraction properties of two polymeric solid phase extraction materials, styryldivinyl benzene (SDB) and 'Oasis' have been compared with those of a base deactivated C8 bonded silica gel using a range of acidic and basic test analytes. In the case
Chao-Bin Xue et al.
Bioorganic & medicinal chemistry, 15(5), 2006-2015 (2007-01-30)
Phenoloxidase (PO), also known as tyrosinase, is a key enzyme in insect development, responsible for catalyzing the hydroxylation of tyrosine into o-diphenols and the oxidation of o-diphenols into o-quinones. Inhibition of PO may provide a basis for novel environmentally friendly
N Dodoff et al.
Journal of inorganic biochemistry, 60(4), 257-266 (1995-12-01)
The complexes [Pt(NH3)(pmbah)Cl2], [Pt(NH3)(pcbah)Cl2], [Pt(pmbah)2X2] and [Pt(pcbah)2X2] (pmbah = 4-methoxybenzoic acid hydrazide, pcbah = 4-chlorobenzoic acid hydrazide; X = Cl, Br, I) have been synthesized and characterized by elemental analysis, electric conductivity, 1H NMR, IR, and electronic spectra. A cis-square
Olakunle S Idowu et al.
Journal of AOAC International, 88(4), 1108-1113 (2005-09-13)
The kinetics of thermal decomposition of 4-carboxyl-2,6-dinitrobenzenediazonium ion (CDNBD), an arenediazonium ion newly developed as a derivatizing reagent for drug analysis, are described. The arenediazonium ion, in an optimized concentrated sulfuric acid/orthophosphoric acid medium, was incubated for various time intervals
Fabrizio Carta et al.
Bioorganic & medicinal chemistry letters, 21(8), 2521-2526 (2011-03-16)
The inhibition of the β-carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic fungi Cryptococcus neoformans (Can2) and Candida albicans (Nce103) with a series of 25 branched aliphatic and aromatic carboxylates has been investigated. Human isoforms hCA I and II were
K Sekar et al.
Acta crystallographica. Section D, Biological crystallography, 62(Pt 4), 392-397 (2006-03-23)
The lipolytic enzyme phospholipase A2 plays a crucial role in lipid metabolism and catalyzes hydrolysis of the fatty-acid ester bond at the sn-2 position of phospholipids. Here, the crystal structure (1.7 A resolution) of the triple mutant (K53,56,121M) of bovine
Y Yang et al.
Guang pu xue yu guang pu fen xi = Guang pu, 17(3), 16-19 (1997-06-01)
The title complex with the formula EuL3 x phen x H2O (phen=1, 10-phenathroline, HL=p-anisic acid) were synthesized and characterized by elemental analysis, molar conductivity, IR, UV, NMR etc.
H Twilfer et al.
European journal of biochemistry, 267(19), 5926-5934 (2000-09-21)
Using 4-methoxybenzoate monooxygenase from Pseudomonas putida, the substrate deuterium isotope effect on product formation and the solvent isotope effect on the stoichiometry of oxygen uptake, NADH oxidation, product and/or H2O2 (D2O2) formation for tight couplers, partial uncouplers, and uncouplers as
H Thoma et al.
Journal of chromatography, 309(1), 17-32 (1984-07-13)
A two-step ultrafiltration method combined with anion-exchange chromatography is described for the separation of lipophilic and strongly lipophobic acids occurring in human blood, serum and plasma. After treatment with diazomethane, the acid fractions are separated further by gas chromatography. The
Stephen G Bell et al.
Dalton transactions (Cambridge, England : 2003), 41(28), 8703-8714 (2012-06-15)
The crystal structures of the 4-methoxybenzoate bound forms of cytochrome P450 enzymes CYP199A2 and CYP199A4 from the Rhodopseudomonas palustris strains CGA009 and HaA2 have been solved. The structures of these two enzymes, which share 86% sequence identity, are very similar
M Shirane et al.
Brain research, 916(1-2), 211-221 (2001-10-13)
Aniracetam, a cognition enhancer, has been recently found to preferentially increase extracellular levels of dopamine (DA) and serotonin (5-HT) in the prefrontal cortex (PFC), basolateral amygdala and dorsal hippocampus of the mesocorticolimbic system in stroke-prone spontaneously hypertensive rats. In the
Mariana C F C B Damião et al.
Archiv der Pharmazie, 347(12), 885-895 (2014-10-07)
A novel class of benzo[d][1,3]dioxol-5-ylmethyl alkyl/aryl amide and ester analogues of capsaicin were designed, synthesized, and evaluated for their cytotoxic activity against human and murine cancer cell lines (B16F10, SK-MEL-28, NCI-H1299, NCI-H460, SK-BR-3, and MDA-MB-231) and human lung fibroblasts (MRC-5).
H Todoriki et al.
Journal of chromatography, 310(2), 273-281 (1984-10-12)
This paper describes the use of a high-performance liquid chromatograph equipped with an ultraviolet multi-detection system for the analysis of aromatic acids to help establish a high-risk screening system for disorders of organic acid metabolism. The peak height ratios of
N Chaves et al.
Journal of chemical ecology, 27(3), 611-621 (2001-07-10)
Eleven allelochemicals (ferulic acid, cinnamic acid, 4-hydroxybenzoic acid, hydroxycinnamic acid, methyl propionate, oxalic acid, methylmalonic acid, p-anisic acid, butyric acid, 3-hydroxybutyric acid, and azulene) were identified in the exudate of Cistus ladanifer L. We studied the effect of each on
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