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Sushma Bartaula-Brevik et al.
Stem cell research & therapy, 5(6), 143-143 (2014-12-22)
Inflammation plays a crucial role in tissue regeneration, wound healing, and the success of tissue-engineered constructs. The aim of this study was to investigate the influence of human umbilical vein endothelial cells (ECs) on leukocyte transmigration when co-cultured with primary
Kun Liu et al.
Autophagy, 11(2), 271-284 (2015-02-05)
Recent evidence that excessive lipid accumulation can decrease cellular levels of autophagy and that autophagy regulates immune responsiveness suggested that impaired macrophage autophagy may promote the increased innate immune activation that underlies obesity. Primary bone marrow-derived macrophages (BMDM) and peritoneal
Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity.
Callahan KP, Minhajuddin M, Corbett C, et al.
Leukemia, 28(10), 1960-1968 (2014)
K Hock et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 14(9), 2011-2022 (2014-08-08)
Bone marrow (BM) transplantation under costimulation blockade induces chimerism and tolerance. Cotransplantation of donor T cells (contained in substantial numbers in mobilized peripheral blood stem cells and donor lymphocyte infusions) together with donor BM paradoxically triggers rejection of donor BM
Zhiqiang Chang et al.
TheScientificWorldJournal, 2014, 794756-794756 (2014-07-12)
The adjuvant chemotherapy, such as cisplatin, doxorubicin, and methotrexate has significantly improved survival of osteosarcoma patients. However, the chemoresistance which arose with the chemotherapy blocks achieving favorable outcomes for some patients and finally led to relapse or metastatic disease. Studies
Mariana Portovedo et al.
PloS one, 10(3), e0119850-e0119850 (2015-03-19)
Autophagy is an important process that regulates cellular homeostasis by degrading dysfunctional proteins, organelles and lipids. In this study, the hypothesis that obesity could lead to impairment in hypothalamic autophagy in mice was evaluated by examining the hypothalamic distribution and
Rui Pedro Galvao et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(40), E4214-E4223 (2014-09-24)
How malignant gliomas arise in a mature brain remains a mystery, hindering the development of preventive and therapeutic interventions. We previously showed that oligodendrocyte precursor cells (OPCs) can be transformed into glioma when mutations are introduced perinatally. However, adult OPCs
Zhenxing Liu et al.
International journal of oncology, 46(2), 721-731 (2014-11-26)
Imidazole, an organic alkaloid, is an important pharmacophore in drug discovery. Anti-neoplastic potential of imidazole derivatives has been documented in several studies; however, mechanisms by which tumor cells respond to these stimuli remain to be elucidated. Autophagy and apoptosis have
Kaitlin H Maditz et al.
Journal of pediatric gastroenterology and nutrition, 60(4), 467-473 (2015-03-31)
In polycystic liver disease (PCLD), multiple cysts cause liver enlargement, structural damage, and loss of function. Soy protein and dietary ω-3 polyunsaturated fatty acids (n-3 PUFAs) have been found to decrease cyst proliferation and inflammation in polycystic kidney disease. Therefore
Ping Quan et al.
Anticancer research, 34(6), 2883-2897 (2014-06-13)
Endometrial stromal sarcoma (ESS) is a rare gynecological mesenchymal malignancy with only few therapeutic options. This study aimed to investigate the efficacy of the histone deacetylase (HDAC) inhibitor suberanilohydroxamic acid (SAHA) combined with inhibitors of the phosphoinositid-3-Kinase (PI3K) pathway in
Keith Melancon et al.
Transplantation, 96(12), 1073-1081 (2013-12-19)
Everolimus (EVR) has demonstrated good efficacy after renal transplantation. Racial disparities in clinical outcomes after de novo renal transplantation are well documented; whether the efficacy of EVR varies based on recipient ethnicity is unknown. We conducted a comparative risk assessment
Fausto Feres et al.
JAMA, 310(23), 2510-2522 (2013-11-02)
The current recommendation is for at least 12 months of dual antiplatelet therapy after implantation of a drug-eluting stent. However, the optimal duration of dual antiplatelet therapy with specific types of drug-eluting stents remains unknown. To assess the clinical noninferiority
A Theil et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 47(1), 48-55 (2014-11-06)
Cord blood has been used as a cell source for therapeutic purposes in children with type 1 diabetes and other disorders. Here, we explore the benefits of cord blood as an autologous source of T regulatory cells for immune cell
Suzanne Schubbert et al.
Cancer research, 74(23), 7048-7059 (2014-10-08)
Disease relapse remains the major clinical challenge in treating T-cell acute lymphoblastic leukemia (T-ALL), particularly those with PTEN loss. We hypothesized that leukemia-initiating cells (LIC) are responsible for T-ALL development and treatment relapse. In this study, we used a genetically
Qilong Gao et al.
Journal of applied toxicology : JAT, 35(5), 485-492 (2014-09-03)
The therapeutic goal of cancer treatment is now geared towards triggering tumour-selective cell death with autophagic cell death being required for the chemotherapy of apoptosis-resistant cancer. In this study, Carnosic acid (CA), a polyphenolic diterpene isolated from Rosemary (Rosemarinus officinalis)
Nader Husseinzadeh et al.
Gynecologic oncology, 133(2), 375-381 (2014-02-22)
The mechanistic (mammalian) targets of rapamycin (mTOR) inhibitors with known growth Inhibitory effect are currently in clinical trial for treatment of human cancer. The aim of this review is to present current incorporating these new drugs as single agents or
Jason M Dwyer et al.
Biological psychiatry, 73(12), 1189-1198 (2013-01-09)
Antidepressants that produce rapid and robust effects, particularly for severely ill patients, represent one of the largest unmet medical needs for the treatment of depression. Currently available drugs that modulate monoamine neurotransmission provide relief for only a subset of patients
Heidi L Kenerson et al.
PloS one, 10(2), e0117000-e0117000 (2015-02-04)
Insulin resistance is an important contributing factor in non-alcoholic fatty liver disease. AKT and mTORC1 are key components of the insulin pathway, and play a role in promoting de novo lipogenesis. However, mTORC1 hyperactivity per se does not induce steatosis
Thu N Huynh et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(27), 9034-9039 (2014-07-06)
Memory retrieval, often termed reconsolidation, can render previously consolidated memories susceptible to manipulation that can lead to alterations in memory strength. Although it is known that reconsolidation requires mammalian target of rapamycin complex 1 (mTORC1)-dependent translation, the specific contributions of
Lisa Nonnenmacher et al.
International journal of cancer, 136(4), E173-E187 (2014-08-16)
Glioblastoma is a highly aggressive, common brain tumor with poor prognosis. Therefore, this study examines a new therapeutic approach targeting oncogenic and survival pathways combined with common chemotherapeutics. The RIST (rapamycin, irinotecan, sunitinib, temozolomide) and the variant aRIST (alternative to
Pynskhem Bok Swer et al.
Indian journal of experimental biology, 52(4), 295-304 (2014-04-30)
Natural autophagy and autophagic cell death is being studied in the model system, D. discoideum, which has well known genetic and experimental advantages over the other known systems. There is no apoptotic machinery present in this organism which could interfere
J Nie et al.
Oncogene, 33(28), 3677-3687 (2013-09-03)
Dysregulation of cellular signaling pathways can lead to colon cancer. However, research on the key signaling effectors or regulators in colon carcinogenesis is limited. Casein kinase-2 interacting protein-1 (CKIP-1; also known as PLEKHO1) is crucial during adult bone formation and
Hongxia Chen et al.
BMC cancer, 15, 103-103 (2015-04-18)
Lymphangiogenesis plays a significant role in metastasis and recurrence of gastric cancer. There is no report yet focusing on the modulation of VEGF pathway and lymphangiogenesis of gastric cancer by targeting Akt/mTOR pathway. This study aims to demonstrate the relationship
Guoxin Ren et al.
Oncology reports, 31(6), 2804-2810 (2014-04-17)
Toll-like receptor 4 (TLR4) is expressed in head and neck squamous cell carcinoma (HNSCC) cells and is associated with HNSCC cancer progression. Rapamycin has been proven to be efficient for the treatment of HNSCC in vivo, yet the mechanism is not understood and
Rina Yagasaki et al.
Experimental eye research, 129, 127-134 (2014-12-03)
We aimed to determine the role of age-related changes in the mammalian target of rapamycin (mTOR) activity in endothelial cell growth during retinal vascular development in mice. Mice were administered the mTOR inhibitor rapamycin as follows: (i) for 6 days
Mirna Mourtada-Maarabouni et al.
Clinical lymphoma, myeloma & leukemia, 14(6), 468-473 (2014-04-08)
Inhibition of the mammalian target of rapamycin (mTOR) pathway is a promising strategy for the treatment of mantle cell lymphoma (MCL). ncRNA growth arrest-specific 5 (GAS5), a 5' terminal oligopyrimidine (5'TOP) RNA regulated by the mTOR pathway, is necessary and
Giuseppe Gangarossa et al.
Hippocampus, 24(12), 1466-1481 (2014-07-22)
The acute activation of the dopamine D1-like receptors (D1R) is involved in a plethora of functions ranging from increased locomotor activity to the facilitation of consolidation, storage, and retrieval of memories. Although much less characterized, epileptiform activities, usually triggered by
Markella Ponticos et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(1), 243-253 (2014-10-11)
The excessive deposition of extracellular matrix, including type I collagen, is a key aspect in the pathogenesis of connective tissue diseases such as systemic sclerosis (SSc; scleroderma). To further our understanding of the mechanisms governing the dysregulation of type I
Jae-Hyung Roh et al.
The American journal of cardiology, 113(10), 1639-1646 (2014-03-29)
Many studies have reported comparable risk of hard end points between percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) for unprotected left main coronary artery (ULMCA) stenosis. However, there are limited data regarding the morbidity associated with ULMCA
Seung-Il Choi et al.
Biochemical and biophysical research communications, 450(4), 1505-1511 (2014-07-22)
Granular corneal dystrophy type 2 (GCD2) is an autosomal dominant disorder that is caused by a point mutation in transforming growth factor-β-induced gene-h3 (TGFBI), which encodes transforming growth factor-β-induced protein (TGFBIp). Recently, we found that the autophagic clearance of mutant-TGFBIp
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