Merck
Search Within
Applied Filters:
Keyword:'34875'
Showing 1-30 of 133 results for "

34875

" within Papers
Sort by Relevance
João Cleverson Gasparetto et al.
PloS one, 10(3), e0118922-e0118922 (2015-03-11)
For decades guaco species have been empirically used for the treatment of respiratory diseases. However, studies have shown that the toxic and therapeutic effects of the main guaco metabolites are dose-dependent, and none clinical study was done to evaluate the
J-F Li et al.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 33(10), 1725-1732 (2014-05-09)
Hepatic steatosis affects disease progression in patients with chronic hepatitis C virus (HCV) infection. We investigated the plasma sphingolipid profile in patients with chronic hepatitis C (CHC) and whether there was an association between HCV-related steatosis and plasma sphingolipids. We
Topical dissolution treatment of cholesterol gallstones with methyl tert-butyl ether.
J L Thistle
Seminars in liver disease, 10(3), 187-190 (1990-08-01)
Scott Phillips et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 4(2), 115-126 (2008-06-24)
This paper reviews the published information assessing the kinetics and potential for adverse health effects related to exposure to the fuel oxygenate, methyl tert-butyl ether (MTBE). Data were obtained from previously published reports, using human data where possible. If human
Liangpo Liu et al.
Journal of separation science, 38(2), 247-253 (2014-11-12)
In this study, a novel method for the analysis of perfluorinated compounds in whole blood has been developed and validated. The method was developed by using a conventional reversed-phase C18 column as a trapping column for the elimination of background
I Zabaleta et al.
Journal of chromatography. A, 1387, 13-23 (2015-02-25)
An analytical method for the simultaneous determination in fish liver and muscle tissue and mussel samples of 14 perfluorinated compounds (PFCs), including three perfluoroalkylsulfonates (PFSAs), seven perfluorocarboxylic acids (PFCAs), three perfluorophosphonic acids (PFPAs) and perfluorooctanesulfonamide (PFOSA), and 10 potential precursors
Ceinwen A Schreiner et al.
Regulatory toxicology and pharmacology : RTP, 70(2 Suppl), S29-S34 (2014-05-24)
Micronucleus and sister chromatid exchange (SCE) tests were performed for vapor condensate of baseline gasoline (BGVC), or gasoline with oxygenates, methyl tert-butyl ether (G/MTBE), ethyl tert butyl ether (G/ETBE), t-amyl methyl ether (G/TAME), diisopropyl ether (G/DIPE), t-butyl alcohol (TBA), or
Susan M Christner et al.
Journal of pharmaceutical and biomedical analysis, 100, 199-204 (2014-08-30)
Epothilones are relatively new tubulin-poison anticancer drugs. Iso-fludelone (KOS-1803) is a synthetic third generation epothilone drug discovered at Memorial Sloan Kettering Cancer Center, and currently in phase I clinical trials. We report an LC-MS/MS assay for the sensitive, accurate and
Yuru Wang et al.
Environmental science & technology, 48(24), 14534-14542 (2014-11-26)
A sulfate radical-based advanced oxidation process (SR-AOP) has received increasing application interest for the removal of water/wastewater contaminants. However, limited knowledge is available on its side effects. This study investigated the side effects in terms of the production of total
Enrico Gerace et al.
Forensic science international, 243, 68-73 (2014-05-23)
The distribution of mephedrone in the body fluids and tissues of a subject found dead after the concomitant intake of cocaine and mephedrone is reported. Mephedrone (4-methylmethcathinone) is a designer drug of the phenethylamine family that is able to cause
Rikako Takahiro et al.
Biological & pharmaceutical bulletin, 38(1), 58-65 (2015-03-07)
The aim of this study was to characterize the kinetics of metabolite formation of the phosphodiesterase type-5 (PDE5) inhibitors sildenafil and tadalafil by CYP3A4, CYP3A5, and CYP3A7 isoforms. The formations of N-desmethyl sildenafil and desmethylene tadalafil were examined using CYP3A
Damayanthi Devineni et al.
Clinical therapeutics, 37(3), 610-628 (2015-02-11)
Canagliflozin is a sodium-glucose cotransporter 2 inhibitor approved for the treatment of type 2 diabetes mellitus (T2DM). Because T2DM is often associated with renal or hepatic impairment, understanding the effects of these comorbid conditions on the pharmacokinetics of canagliflozin, and
Sylvain Merel et al.
Chemosphere, 127, 238-245 (2015-03-10)
N,N-diethyl-m-toluamide (DEET), the active component of many insect repellents, is among the most frequently detected compounds in aqueous environments with concentrations reported in the ng L(-1) to μg L(-1) range. However, DEET is often detected in blanks and reported concentrations
Julie A Ray et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 970, 102-107 (2014-09-24)
Accurate measurement of aldosterone is important for the standardized testing of primary hyperaldosteronism. Commercial immunoassays show substantial between-method variations resulting in significant clinical consequences. We developed a specific two dimensional (2D)-LC-MS/MS method for measuring aldosterone in human serum and plasma
J Scott Boone et al.
Journal of chromatography. A, 1345, 68-77 (2014-05-06)
A trace analytical method was developed for the determination of seventeen specific perfluorinated chemicals (PFCs) in environmental and drinking waters. The objectives were to optimize an isotope-dilution method to increase the precision and accuracy of the analysis of the PFCs
Sahar Ghasemi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 971, 112-119 (2014-10-04)
Methyl-tert-butyl ether (MTBE) is widely used as an antiknock additive for increasing octane number of gasoline. Recently, the in vivo studies demonstrated that MTBE has genotoxic potential and able to form adducts with DNA. In the work, the interactions of
Sarah K Abbott et al.
Lipids, 48(3), 307-318 (2013-01-29)
We have developed a protocol suitable for high-throughput lipidomic analysis of human brain samples. The traditional Folch extraction (using chloroform and glass-glass homogenization) was compared to a high-throughput method combining methyl-tert-butyl ether (MTBE) extraction with mechanical homogenization utilizing ceramic beads.
Ping Du et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 28-35 (2014-07-27)
Docetaxel lipid microsphere (DT-LM) is a novel formulation of docetaxel without Tween-80. A sensitive, robust and reproducible ultrafiltration (UF) followed by UPLC-MS/MS method was developed and validated for the quantification of unbound docetaxel in human plasma using paclitaxel as IS.
Jérôme Cotton et al.
Journal of agricultural and food chemistry, 62(46), 11335-11345 (2014-10-31)
Analytical methods for food control are mainly focused on restricted lists of well-known contaminants. This paper shows that liquid chromatography-high-resolution mass spectrometry (LC/ESI-HRMS) associated with the data mining tools developed for metabolomics can address this issue by enabling (i) targeted
Laura J Owen et al.
Annals of clinical biochemistry, 50(Pt 5), 489-491 (2013-07-31)
Supported liquid extraction (SLE) techniques are relatively new compared to other sample preparation approaches such as solid phase extraction (SPE), liquid-liquid extraction (LLE) and protein precipitation (PPE). We investigated the use of SLE as an alternative to SPE for the
Sylvain Merel et al.
Journal of hazardous materials, 282, 75-85 (2014-09-30)
In response to water scarcity, strategies relying on multiple processes to turn wastewater effluent into potable water are being increasingly considered by many cities. In such context, the occurrence of contaminants as well as their fate during treatment processes is
Cuihua Liu et al.
Journal of the science of food and agriculture, 95(1), 111-119 (2014-04-12)
Terpenoids are major components of carotenoids, limonoids and aromas in citrus fruits, resulting in fruit coloration, bitterness and aroma. In this study the carotenoid, limonoid and volatile profiles of red-flesh Chuhong pummelo (CH) and pale green-flesh Feicui pummelo (FC) were
Juan C Domínguez-Romero et al.
Journal of chromatography. A, 1361, 34-42 (2014-08-21)
Sample preparation is a critical step in large-scale multiclass analysis such as sport drug testing. Due to the wide heterogeneity of the analytes and the complexity of the matrix, the selection of a correct sample preparation method is essential, looking
Chang Li et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 75, 8-13 (2014-12-03)
3-monochoropropane-1, 2-diol (3-MCPD) esters from edible oils are considered to be a possible risk factor for adverse effects in human. In the present study, the exposure assessment of 3-MCPD esters to Chinese population was performed. A total of 143 edible
Nils Reiche et al.
Environmental monitoring and assessment, 185(9), 7133-7144 (2013-01-19)
Phytoscreening of phytoremediation-based plantings is discussed as a promising monitoring tool in literature. We developed and applied an analytical procedure for the in vivo sampling of methyl tert-butyl ether (MTBE) in the common reed (Phragmites australis) from a phytoremediation site
Y G Zhao et al.
Marine pollution bulletin, 83(1), 148-154 (2014-04-30)
Surface sediment and biota were collected from 12 sampling sites - seven along the Pearl River Delta and five along the Hong Kong coastline. Perfluorinated compound (PFC) concentrations were detected using a high-performance-liquid-chromatogram-tandem-mass-spectrometry system. Analytical results indicated that the total
É V Trifonova et al.
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, (4)(4), 16-20 (2013-02-14)
In article the data on interrelation between gallbladder contractility and a level of hormones of a thyroid gland (threeiodethyronine, thyroxine, thyrotropin hormone (TTH) and antibodies to thyreoperoxidase (AT to TPO)) in plasma of blood at 470 healthy persons and 540
Nicolas Lopes Ferreira et al.
Applied microbiology and biotechnology, 72(2), 252-262 (2006-06-29)
Fuel oxygenates, mainly methyl tert-butyl ether (MTBE) but also ethyl tert-butyl ether (ETBE), are added to gasoline in replacement of lead tetraethyl to enhance its octane index. Their addition also improves the combustion efficiency and therefore decreases the emission of
Andy Hutson et al.
Chemosphere, 89(10), 1218-1223 (2012-08-28)
Chemical oxidation regeneration of granular activated carbon (GAC) is a developing technology that can be carried out utilizing thermally-activated persulfate. During chemical regeneration of GAC, aggressive oxidative conditions lead to high acidity (pH<2) and the accumulation of sodium persulfate residuals
Li Zhen Zhang et al.
Food chemistry, 174, 495-501 (2014-12-23)
Commonly consumed foxtail millet varieties Jingu28 and Jingu34 were compared in terms of phytochemical composition, antioxidant property, and antiproliferative activity. The cellular antioxidant activity (CAA) was evaluated based on HepG2 cell cultivation. Antiproliferative properties against HepG2 and MDA cell were
Page 1 of 5
Page 1 of 5