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Showing 1-30 of 6381 results for "28-3285" within Papers
Hina Y Bhutta et al.
PloS one, 10(3), e0122273-e0122273 (2015-03-24)
In addition to classic functions of facilitating hepatobiliary secretion and intestinal absorption of lipophilic nutrients, bile acids (BA) are also endocrine factors and regulate glucose and lipid metabolism. Recent data indicate that antiobesity bariatric procedures e.g. Roux-en-Y gastric bypass surgery
Alessandra Fiorio Pla et al.
BMC cancer, 14, 939-939 (2014-12-17)
Prostate cancer is the second leading cause of male cancer death in developed countries. Although the role of angiogenesis in its progression is well established, the efficacy of anti-angiogenic therapy is not clearly proved. Whether this could depend on differential
Orwa Aboud et al.
Frontiers in cellular neuroscience, 9, 103-103 (2015-04-11)
Reports from neural cell cultures and experimental animal studies provide evidence of age- and disease-related changes in retrograde transport of spent or misfolded proteins destined for degradation or recycling. However, few studies address these issues in human brain from those
Lorena Garaicoechea et al.
PloS one, 10(8), e0133665-e0133665 (2015-08-13)
Noroviruses are a major cause of acute gastroenteritis, but no vaccines or therapeutic drugs are available. Llama-derived single chain antibody fragments (also called VHH) are small, recombinant monoclonal antibodies of 15 kDa with several advantages over conventional antibodies. The aim
Bassam Abomoelak et al.
Journal of bacteriology, 191(19), 5941-5952 (2009-08-04)
Latent tuberculosis represents a high-risk burden for one-third of the world population. Previous analysis of murine tuberculosis identified a novel transcriptional regulator encoded by Rv0348 that could control the establishment of persistent tuberculosis. Disruption of the Rv0348 gene from the
M F van Tilburg et al.
International journal of biometeorology, 59(5), 561-573 (2014-08-05)
The Saanen is a highly productive breed, and for this reason, it has been raised in Brazil, but mostly under climate conditions completely different from where the breed originated. The objective of this study was to investigate variations in semen
Munetsugu Hara et al.
Scientific reports, 5, 11204-11204 (2015-06-16)
Methyl-CpG-binding protein 2 (MeCP2) is an epigenetic regulator of gene expression that is essential for normal brain development. Mutations in MeCP2 lead to disrupted neuronal function and can cause Rett syndrome (RTT), a neurodevelopmental disorder. Previous studies reported cardiac dysfunction
Silvia Moretti et al.
PLoS pathogens, 10(11), e1004462-e1004462 (2014-11-07)
Since IL-37 transgenic mice possesses broad anti-inflammatory properties, we assessed whether recombinant IL-37 affects inflammation in a murine model of invasive pulmonary aspergillosis. Recombinant human IL-37 was injected intraperitoneally into mice prior to infection and the effects on lung inflammation
Louise M Collins et al.
Molecular neurobiology, 51(3), 1432-1442 (2014-07-30)
Small molecule histone deacetylase inhibitors (HDIs) hold much promise as pharmacological modifiers of the epigenetic status of the central nervous system (CNS), given their ability to cross the blood-brain barrier. This is particularly relevant given the lack of disease-modifying therapies
Huatuo Zhu et al.
Scientific reports, 5, 12227-12227 (2015-07-18)
Ulcerative colitis (UC) is a common inflammatory bowel disease (IBD) producing intestinal inflammation and tissue damage. The precise aetiology of UC remains unknown. In this study, we applied a rank-based expression profile comparative algorithm, gene set enrichment analysis (GSEA), to
Vera Gesheva et al.
International immunopharmacology, 26(1), 162-168 (2015-03-25)
New generated subunit vaccines are characterized by increased safety and lack of side effects, however they suffer from weak immunogenicity. The adjuvants are substances that have the ability to enhance the magnitude and duration of the immune response and to
Joan Eilstein et al.
Archives of toxicology, 88(9), 1681-1694 (2014-03-25)
Skin function is not limited to a physical barrier. According to its total surface area, it is also considered as an extra-hepatic metabolizing organ. In vitro engineered human skins have been developed to replace limited ex vivo normal human skin
Monica Locatelli et al.
Journal of agricultural and food chemistry, 63(32), 7294-7303 (2015-08-01)
Hazelnuts belonging to different cultivars or cultivated in different geographic areas can be differentiated by their chemical profile; however, the roasting process may affect the composition of raw hazelnuts, thus compromising the possibility to identify their origin in processed foods.
Gang Hou et al.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 27, 13-17 (2014-08-19)
The definitive diagnosis of endobronchial tuberculosis (EBTB) is challenging because the disease manifests in various non-specific ways, and acid-fast bacilli (AFB) are often undetectable by sputum smear. The objective of this study was to evaluate the efficacy of real-time PCR
Michele C Darrow et al.
The Journal of biological chemistry, 290(28), 17451-17461 (2015-05-23)
Huntington disease, a neurodegenerative disorder characterized by functional deficits and loss of striatal neurons, is linked to an expanded and unstable CAG trinucleotide repeat in the huntingtin gene (HTT). This DNA sequence translates to a polyglutamine repeat in the protein
Masayuki Koizumi et al.
Journal of atherosclerosis and thrombosis, 21(9), 904-916 (2014-04-15)
Vascular senescence, which is accelerated in individuals with chronic kidney disease (CKD), contributes to the development of cardio-renal syndrome, and various uremic toxins may play important roles in the mechanisms underlying this phenomenon. We recently reported that indoxyl sulfate (IS)
Richard S Rogers et al.
mAbs, 7(5), 881-890 (2015-07-18)
Regulatory agencies have recently recommended a Quality by Design (QbD) approach for the manufacturing of therapeutic molecules. A QbD strategy requires deep understanding at the molecular level of the attributes that are crucial for safety and efficacy and for insuring
Cristina W Cunha et al.
PloS one, 10(7), e0131129-e0131129 (2015-07-18)
Herpes simplex virus 1 (HSV-1) ICP0 is a multi-functional phosphoprotein expressed with immediate early kinetics. An ICP0 deletion mutant, HSV-1 dl1403, has been widely used to study the roles of ICP0 in the HSV-1 replication cycle including gene expression, latency
Divya Pathania et al.
British journal of pharmacology, 172(1), 50-63 (2014-07-23)
Pancreatic cancer is characterized by alterations in several key signalling proteins, including increased expression and activity of the Src tyrosine kinase and focal adhesion kinase (FAK), which have been linked to its chemoresistance. Sustained Src inhibition reactivates survival pathways regulated
Devadoss J Samuvel et al.
PloS one, 10(10), e0141781-e0141781 (2015-10-30)
Sphingosine-1-phosphate receptor 1 (S1P1) mediated regulation of lymphocyte egress from lymphoid organs is recognized as the mechanism of FTY720 (Fingolimod, Gilenya) efficacy in relapsing-remitting forms of multiple sclerosis (RRMS). In this study we describe a novel S1P1 agonist AKP-11, next
Emiley A Eloe-Fadrosh et al.
mBio, 6(2) (2015-04-16)
A mechanistic understanding of the purported health benefits conferred by consumption of probiotic bacteria has been limited by our knowledge of the resident gut microbiota and its interaction with the host. Here, we detail the impact of a single-organism probiotic
Filipe V Jacinto et al.
Genes & development, 29(12), 1224-1238 (2015-06-18)
Nucleoporins (Nups) are a family of proteins best known as the constituent building blocks of nuclear pore complexes (NPCs), membrane-embedded channels that mediate nuclear transport across the nuclear envelope. Recent evidence suggests that several Nups have additional roles in controlling
Raquel Ordoñez et al.
Journal of pineal research, 59(2), 178-189 (2015-05-16)
Autophagy is a process that maintains homeostasis during stress, although it also contributes to cell death under specific contexts. Ceramides have emerged as important effectors in the regulation of autophagy, mediating the crosstalk with apoptosis. Melatonin induces apoptosis of cancer
Xinli Liu et al.
International immunopharmacology, 25(2), 416-424 (2015-02-24)
Non-small cell lung cancer (NSCLC) is highly prevalent and needs novel therapies. Melanoma-associated antigen 3 (MAGE-A3) is a lung cancer antigen and calreticulin (CALR) can modulate immune responses. Our previous study has shown that up-regulated MAGE-A3 and CALR expression inhibits
Prakash Parajuli et al.
AMB Express, 4, 31-31 (2014-06-21)
Epothilones are extremely cytotoxic chemotherapeutic agents with epoxide, thiazole, and ketone groups that share equipotent kinetic similarity with taxol. The in vitro glycosylation catalyzed by uridine diphosphate glucosyltransferase (YjiC) from Bacillus licheniformis generated six novel epothilone A glycoside analouges including
Joanne E Mallinson et al.
The Journal of physiology, 593(5), 1239-1257 (2015-01-27)
Statins are associated with muscle myalgia and myopathy, which probably reduce habitual physical activity. This is particularly relevant to older people who are less active, sarcopaenic and at increased risk of statin myalgia. We hypothesised that statin myalgia would be
Zhiqiang Jia et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(8), 1312-1321 (2015-07-04)
The aims of this study were, first, to investigate the toxicity of zearalenone (ZEN) through the analysis of biochemical parameters, oxidative stress, pathological changes and inflammatory response in the kidney of gestation sows and offspring; and, second, to evaluate the
Peter S Hasenhuetl et al.
Molecular pharmacology, 88(1), 12-18 (2015-04-16)
The membrane transporters for the monoamines serotonin (SERT) and dopamine (DAT) are prominent targets of various psychoactive substances, including competitive inhibitors, such as tricyclic antidepressants, methylphenidate, and cocaine. Upon rapid application of a substrate, SERT and DAT display an inwardly
Maria Fernanda Hornos Carneiro et al.
Environmental toxicology, 30(12), 1423-1433 (2014-06-20)
Thimerosal is an ethyl mercury-containing compound used mainly in vaccines as a bactericide. Although the kidney is a key target for mercury toxicity, thimerosal nephrotoxicity has not received the same attention as other mercury species. The aim of this study
J Kowshik et al.
PloS one, 9(10), e109114-e109114 (2014-10-09)
Identifying agents that inhibit STAT-3, a cytosolic transcription factor involved in the activation of various genes implicated in tumour progression is a promising strategy for cancer chemoprevention. In the present study, we investigated the effect of dietary astaxanthin on JAK-2/STAT-3
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