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Zhi-Wei Chen et al.
Nucleic acids research, 42(18), 11560-11569 (2014-09-25)
Human single-strand (ss) DNA binding proteins 1 (hSSB1) has been shown to participate in DNA damage response and maintenance of genome stability by regulating the initiation of ATM-dependent signaling. ATM phosphorylates hSSB1 and prevents hSSB1 from ubiquitin-proteasome-mediated degradation. However, the
Kathrin Arnhard et al.
Analytical and bioanalytical chemistry, 407(2), 405-414 (2014-11-05)
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become an indispensable analytical technique in clinical and forensic toxicology for detection and identification of potentially toxic or harmful compounds. Particularly, non-target LC-MS/MS assays enable extensive and universal screening requested in systematic toxicological analysis.
Naomi L Kruhlak et al.
Toxicology mechanisms and methods, 18(2-3), 217-227 (2008-01-01)
ABSTRACT Drug-induced phospholipidosis (PL) is a condition characterized by the accumulation of phospholipids and drug in lysosomes, and is found in a variety of tissue types. PL is frequently manifested in preclinical studies and may delay or prevent the development
Khrystyna Yu Sukhanova et al.
Pharmacological reports : PR, 66(3), 363-372 (2014-06-07)
ATP is one of the principal sympathetic neurotransmitters which contracts vascular smooth muscle cells (SMCs) via activation of ionotropic P2X receptors (P2XRs). We have recently demonstrated that contraction of the guinea pig small mesenteric arteries evoked by stimulation of P2XRs
Md Maniruzzaman Manir et al.
Bioorganic & medicinal chemistry, 20(7), 2376-2381 (2012-03-02)
Four new quercetin acylglycosides, designated camelliquercetisides A-D, quercetin 3-O-[α-L-arabinopyranosyl(1→3)][2-O″-(E)-p-coumaroyl][β-D-glucopyranosyl(1→3)-α-L-rhamnopyranosyl(1→6)]-β-D-glucoside (17), quercetin 3-O-[2-O″-(E)-p-coumaroyl][β-D-glucopyranosyl(1→3)-α-L-rhamnopyranosyl(1→6)]-β-D-glucoside (18), quercetin 3-O-[α-L-arabinopyranosyl(1→3)][2-O″-(E)-p-coumaroyl][α-L-rhamnopyranosyl(1→6)]-β-d-glucoside (19), and quercetin 3-O-[2-O″-(E)-p-coumaroyl][α-L-rhamnopyranosyl(1→6)]-β-D-glucoside (20), together with caffeine and known catechins, and flavonoids (1-16) were isolated from the leaves of Camellia sinensis. Their structures were
Dieter Zimmer et al.
Bioanalysis, 5(6), 711-719 (2013-03-15)
The scientifically and logistically best way of application of the internal standard (IS) in the analysis of dried blood spots (DBS) analysis is still a matter of debate and investigation. Most commonly the IS is added in the solvent used
Margarida Galhetas et al.
Journal of colloid and interface science, 433, 94-103 (2014-08-13)
The high carbon contents and low toxicity levels of chars from coal and pine gasification provide an incentive to consider their use as precursors of porous carbons obtained by chemical activation with K2CO3. Given the chars characteristics, previous demineralization and
Pragalathan Naidoo et al.
Pharmacological reports : PR, 66(4), 585-593 (2014-06-21)
The aim of the present study was to develop an alternative non-obese non-genetic rat model of type 2 diabetes (T2D). Six-week-old male SD rats were randomly divided into six groups, namely: Normal Control (NC), Diabetic Control (DBC), Caffeine 5mg/kg BW+STZ
Chuanhai Cao et al.
Journal of Alzheimer's disease : JAD, 42(3), 973-984 (2014-07-16)
The purpose of this study was to investigate the potential therapeutic qualities of Δ9-tetrahydrocannabinol (THC) with respect to slowing or halting the hallmark characteristics of Alzheimer's disease. N2a-variant amyloid-β protein precursor (AβPP) cells were incubated with THC and assayed for
Mirosława Zydroń et al.
Journal of separation science, 27(14), 1166-1172 (2004-11-13)
An SPE method, using RP18 phases, for the simultaneous extraction of caffeine, theobromine, theophylline, paraxanthine, 1-methylxanthine, 3-methylxanthine, 7-methylxanthine, 1-methyluric acid, 1,3-dimethyluric acid, 1,7-dimethyluric acid, and 1,3,7-trimethyluric acid from urine has been developed. Besides a gradient HPLC system for the analysis
Timing of caffeine therapy in very low birth weight infants.
Barbara Schmidt et al.
The Journal of pediatrics, 164(5), 957-958 (2014-03-19)
Ziv Lifshitz et al.
Infection and immunity, 82(9), 3740-3752 (2014-06-25)
Coxiella burnetii, the causative agent of Q fever, is a human intracellular pathogen that utilizes the Icm/Dot type IVB secretion system to translocate effector proteins into host cells. To identify novel C. burnetii effectors, we applied a machine-learning approach to
George P Lahm et al.
Bioorganic & medicinal chemistry letters, 17(22), 6274-6279 (2007-09-22)
Rynaxypyr is a highly potent and selective activator of insect ryanodine receptors with exceptional activity on a broad range of Lepidoptera. A strong correlation between insecticidal activity and ryanodine receptor activation is observed along with selective activity against insect over
Jie Ping et al.
Toxicology, 321, 53-61 (2014-04-11)
Prenatal caffeine ingestion is one of the risk factors for intrauterine growth retardation (IUGR). Adrenal plays a pivotal role, mainly through steroidogenesis, in the regulation of intrauterine homeostasis and in fetal development and maturation. We have shown that prenatal caffeine
S Shah et al.
The European respiratory journal, 27(5), 1066-1068 (2006-05-19)
Hepatic veno-occlusive disease is defined as nonthrombotic fibrous obliterative endophlebitis of small centrilobular hepatic venules. Clinically, patients present with elevated liver enzymes and a triad of jaundice, hepatomegaly and ascites. Although reported as a complication of other solid organ and
Luiz Augusto da Silva et al.
Pharmaceutical biology, 52(8), 956-960 (2014-03-08)
Caffeine can stimulate insulin secretion by attenuating hyperglycemia in diabetes models with significant reduction of pancreatic functional β cells. Knowledge of these mechanisms could contribute to new strategies for treating diabetes. This study evaluated the effects of caffeine and physical
Brian A Mc Ardle et al.
Circulation. Cardiovascular imaging, 7(6), 930-937 (2014-09-04)
Cardiac allograft vasculopathy is a key prognostic determinant after heart transplant. Detection and risk stratification of patients with cardiac allograft vasculopathy are problematic. Positron emission tomography using rubidium-82 allows quantification of absolute myocardial blood flow and may have utility for
Miriam Redondo et al.
European journal of medicinal chemistry, 47(1), 175-185 (2011-11-22)
A simple and efficient synthetic method for the preparation of quinazoline type phosphodiesterase 7 (PDE7) inhibitors, based on microwave irradiation, has been developed. The use of this methodology improved yields and reaction times, providing a scalable procedure. These compounds are
Tom M McLellan et al.
Nutrition reviews, 70(12), 730-744 (2012-12-05)
Energy drinks (EDs) contain caffeine and are a new, popular category of beverage. It has been suggested that EDs enhance physical and cognitive performance; however, it is unclear whether the claimed benefits are attributable to components other than caffeine. A
José R Fernández et al.
Bioorganic & medicinal chemistry, 18(18), 6748-6755 (2010-08-19)
Guanine deaminase (GDA; cypin) is an important metalloenzyme that processes the first step in purine catabolism, converting guanine to xanthine by hydrolytic deamination. In higher eukaryotes, GDA also plays an important role in the development of neuronal morphology by regulating
Bram Baert et al.
Bioorganic & medicinal chemistry, 15(22), 6943-6955 (2007-09-11)
A set of 116 structurally very diverse compounds, mainly drugs, was characterized by 1630 molecular descriptors. The biological property modelled in this study was the transdermal permeability coefficient logK(p). The main objective was to find a limited set of suitable
Caffeine and atrial fibrillation: friends or foes?
Prashant D Bhave et al.
Heart (British Cardiac Society), 99(19), 1377-1378 (2013-09-07)
Robert Lemery et al.
Journal of cardiovascular electrophysiology, 26(1), 1-6 (2014-08-02)
Patients with cardiac arrhythmias are generally instructed to avoid caffeine intake. A comprehensive evaluation of the electrophysiological effects of caffeine on atrial and ventricular tissues in humans has not previously been performed. Eighty patients (31 men, mean age 49 ± 14 years) with symptomatic
Laureen Colis et al.
Oncotarget, 5(12), 4361-4369 (2014-06-24)
DNA intercalation is a major therapeutic modality for cancer therapeutic drugs. The therapeutic activity comes at a cost of normal tissue toxicity and genotoxicity. We have recently described a planar heterocyclic small molecule DNA intercalator, BMH-21, that binds ribosomal DNA
Joshi John et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(6), R704-R710 (2014-07-18)
Histamine neurons are active during waking and largely inactive during sleep, with minimal activity during rapid-eye movement (REM) sleep. Caffeine, the most widely used stimulant, causes a significant increase of sleep onset latency in rats and humans. We hypothesized that
Wolfram Gronwald et al.
Kidney international, 79(11), 1244-1253 (2011-03-11)
Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used multidimensional-multinuclear nuclear magnetic resonance (NMR) spectroscopy with support vector machine-based
Peter Stokes et al.
Rapid communications in mass spectrometry : RCM, 28(18), 2024-2030 (2014-08-19)
The atmospheric pressure solids analysis probe (ASAP) has been successfully introduced into laboratories as a routine analytical tool but the technique is labour-intensive and is not easily automated. This paper describes the modifications made to an existing atmospheric pressure gas
Pu Zhang et al.
Bioorganic & medicinal chemistry letters, 21(1), 338-341 (2010-12-03)
Epiceanothic acid (1) is a naturally occurring, but very rare pentacyclic triterpene with a unique pentacyclic triterpene (PT) structure. An efficient synthesis of 1 starting from betulin (3) has been accomplished in 12-steps with a total yield of 10% in
Seema B Jabbar et al.
The American journal of forensic medicine and pathology, 34(4), 321-324 (2013-11-08)
Caffeine is a central nervous system stimulant that is consumed by large numbers of people on a routine basis, usually in the form of coffee or tea. However, if consumed in high doses, this xanthine alkaloid is profoundly toxic and
Ayako Wada-Katsumata et al.
Science (New York, N.Y.), 340(6135), 972-975 (2013-05-25)
In response to the anthropogenic assault of toxic baits, populations of the German cockroach have rapidly evolved an adaptive behavioral aversion to glucose (a phagostimulant component of baits). We hypothesized that changes in the peripheral gustatory system are responsible for
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