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Liang-Feng Liu et al.
Scientific reports, 5, 16862-16862 (2015-11-19)
Tianma Gouteng Yin (TGY) is a traditional Chinese medicine (TCM) decoction widely used to treat symptoms associated with typical Parkinson's disease (PD). In this study, the neuroprotective effects of water extract of TGY were tested on rotenone-intoxicated and human α-synuclein...
Krysti Todd et al.
Biochimica et biophysica acta, 1842(12 Pt A), 2457-2467 (2014-09-28)
Familial British dementia (FBD) is an early-onset non-amyloid-β (Aβ) cerebral amyloidosis that presents with severe cognitive decline and strikingly similar neuropathological features to those present in Alzheimer's disease (AD). FBD is associated with a T to A single nucleotide transition...
Saeed Shahrokhian et al.
Materials science & engineering. C, Materials for biological applications, 53, 134-141 (2015-06-05)
A novel voltammetric sensor based on glassy carbon electrode (GCE) modified with a thin film of multi-walled carbon nanotubes (MWCNTs) coated with an electropolymerized layer of tiron-doped polypyrrole was developed and the resulting electrode was applied for the determination of...
Yang Wang et al.
The Analyst, 139(23), 6197-6203 (2014-10-10)
In this work, a novel chemically modified electrode is constructed based on metal-organic frameworks and β-cyclodextrin (Cu3(BTC)2/β-CD, BTC = benzene-1,3,5-tricarboxylate) composite material. The electrode was used for simultaneous determination of guanine and adenine in a sequential injection lab-on-valve format and...
Sun-Young Kong et al.
PloS one, 10(2), e0118188-e0118188 (2015-02-24)
Neural stem cells (NSCs) have the ability to proliferate and differentiate into neurons and glia. Regulation of NSC fate by small molecules is important for the generation of a certain type of cell. The identification of small molecules that can...
A Bianchi et al.
Organic & biomolecular chemistry, 13(27), 7530-7541 (2015-06-16)
Integrins are associated with tumour cell survival and progression, and their expression has been shown to be increased in tumours. Thus, four novel conjugates of the tripeptide integrin ligand Arg-Gly-Asp (RGD) and the cytotoxic agent paclitaxel (cRGD-PTX) were prepared to...
Sawanta S Mali et al.
Scientific reports, 5, 11424-11424 (2015-06-23)
Development of ternary metal oxide (TMO) based electron transporting layer (ETL) for perovskite solar cell open a new approaches toward efficient a unique strategy for solid state dye-sensitized solar cells (ssDSSCs). In the present investigation, highly porous zinc tin oxide...
Poonam Srivastava et al.
Nature communications, 6, 7789-7789 (2015-07-25)
Artificial metalloenzymes (ArMs) formed by incorporating synthetic metal catalysts into protein scaffolds have the potential to impart to chemical reactions selectivity that would be difficult to achieve using metal catalysts alone. In this work, we covalently link an alkyne-substituted dirhodium...
Takashi Toyao et al.
ChemSusChem, 8(22), 3905-3912 (2015-09-24)
Various N-doped nanoporous carbons containing metal species were prepared by direct thermal conversion of zeolitic imidazolate frameworks (ZIFs; ZIF-7, -8, -9, and -67) at different temperatures (600, 800, and 1000 °C). These materials were utilized as bifunctional acid-base catalysts to promote...
Şerife Tokalıoğlu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 149, 378-384 (2015-05-15)
In this study, a fast and simple vortex assisted solid phase extraction method was developed for the separation/preconcentration of basic fuchsin in various water samples. The determination of basic fuchsin was carried out at a wavelength of 554 nm by...
Shing Fung Chow et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(2), 462-471 (2014-07-16)
The relative performance of two specially designed mixers for nanoparticle production, namely, two-stream confined impinging jets with dilution mixer (CIJ-D-M) and four-stream multi-inlet vortex mixer (MIVM), was evaluated using the model compound, curcumin (CUR), under defined conditions of varying mixing...
Hongjie An et al.
Enzyme and microbial technology, 68, 15-22 (2014-12-02)
Immobilization of the enzymes on nano-structured materials is a promising approach to enhance enzyme stabilization, activation and reusability. This study aimed to develop polystyrene fiber-enzyme assembles to catalyze model formaldehyde to methanol dehydrogenation reaction, which is an essential step for...
Anna W Sromek et al.
Journal of labelled compounds & radiopharmaceuticals, 57(14), 725-729 (2014-11-18)
Aporphines are attractive candidates for imaging D2 receptor function because, as agonists rather than antagonists, they are selective for the receptor in the high affinity state. In contrast, D2 antagonists do not distinguish between the high and low affinity states...
Mikhail A Kabeshov et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(34), 12026-12033 (2015-07-07)
Comprehensive mechanistic studies on the enantioselective aldol reaction between isatin (1 a) and acetone, catalyzed by L-leucinol (3 a), unraveled that isatin, apart from being a substrate, also plays an active catalytic role. Conversion of the intermediate oxazolidine 4 into the reactive...
Andreas Reisch et al.
ACS nano, 9(5), 5104-5116 (2015-04-22)
Ultrasmall polymer nanoparticles are rapidly gaining importance as nanocarriers for drugs and contrast agents. Here, a straightforward modular approach to efficiently loaded and stable sub-20-nm polymer particles is developed. In order to obtain ultrasmall polymer nanoparticles, we investigated the influence...
Jae-Yeon Shin et al.
Biomolecules & therapeutics, 23(4), 313-319 (2015-07-15)
P7C3 and its derivatives, 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(p-tolylamino)propan-2-ol (1) and N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-hydroxypropyl)-N-(3-methoxyphenyl)-4-methylbenzenesulfonamide (2), were previously reported to increase neurogenesis in rat neural stem cells (NSCs). Although P7C3 is known to increase neurogenesis by protecting newborn neurons, it is not known whether its derivatives also...
Alessia Colombo et al.
Dalton transactions (Cambridge, England : 2003), 44(26), 11788-11796 (2015-06-09)
The synthesis of two new thiocyanate free Ru(II) complexes with different pyrid-2-yl tetrazolate ligands is reported, along with their electrochemical, spectroscopic and theoretical characterization. The corresponding dye-sensitized solar cell devices were prepared, leading to 3.4% conversion efficiency, promising data, considering...
Attractors in Sequence Space: Peptide Morphing by Directed Simulated Evolution.
Jan A Hiss et al.
Molecular informatics, 34(11-12), 709-714 (2016-01-19)
Elisa Pedone et al.
Nature communications, 10(1), 4481-4481 (2019-10-04)
Cellular systems have evolved numerous mechanisms to adapt to environmental stimuli, underpinned by dynamic patterns of gene expression. In addition to gene transcription regulation, modulation of protein levels, dynamics and localization are essential checkpoints governing cell functions. The introduction of...
Ornchuma Naksuriya et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 94, 501-512 (2015-07-03)
Curcumin (CM) has been reported as a potential anticancer agent. However, its pharmaceutical applications as therapeutic agent are hampered because of its poor aqueous solubility. The present study explores the advantages of polymeric micelles composed of block copolymers of methoxypoly(ethylene...
Makhsud I Saidaminov et al.
Nature communications, 6, 7586-7586 (2015-07-07)
Single crystals of methylammonium lead trihalide perovskites (MAPbX3; MA = CH3NH3(+), X = Br(-) or I(-)) have shown remarkably low trap density and charge transport properties; however, growth of such high-quality semiconductors is a time-consuming process. Here we present a...
Elisabetta Schievano et al.
Talanta, 140, 36-41 (2015-06-07)
The first step in caffeine metabolism is mediated for over 95% by the CYP1A2 isoform of cytochrome P450. Therefore, CYP1A2 activity is most conveniently measured through the determination of caffeine clearance. The HPLC quantification of caffeine is fully validated and...
Purushothaman Kuppan et al.
Journal of biomedical materials research. Part A, 103(7), 2236-2250 (2014-10-28)
Poly(ɛ-caprolactone) (PCL) and PCL-gelatin random and aligned nanofibers with diameters in the range of 200-400 nm were developed through electrospinning. Mechanical properties of aligned PCL and PCL-gelatin nanofibers were compared, and it was found that aligned PCL nanofibers showed significantly...
Eddie Y Chung et al.
Nano letters, 15(8), 5025-5032 (2015-07-24)
We developed a quantum-dot-based fluorescence resonance energy transfer (QD-FRET) nanosensor to visualize the activity of matrix metalloproteinase (MT1-MMP) at cell membrane. A bended peptide with multiple motifs was engineered to position the FRET pair at a close proximity to allow...
Xiao Ding et al.
Biomedical chromatography : BMC, 29(8), 1274-1279 (2015-02-14)
An LC-MS/MS method for the determination of GDC-0980 (apitolisib) concentrations in dog plasma has been developed and validated for the first time to support pre-clinical drug development. Following protein precipitation with acetonitrile, the resulting samples were analyzed using reverse-phase chromatography...
Claudia Scholz et al.
ChemMedChem, 9(9), 2104-2110 (2014-02-08)
The optimization of synthetic carriers for gene transfer remains a major challenge. Cationic polymers such as polyethylenimine (PEI) often show increasing gene transfer activity with increasing molecular weight, but this favorable effect is accompanied by an undesired increase in cytotoxicity....
Tristan Gollnest et al.
Nature communications, 6, 8716-8716 (2015-10-28)
The antiviral activity of nucleoside reverse transcriptase inhibitors is often limited by ineffective phosphorylation. We report on a nucleoside triphosphate (NTP) prodrug approach in which the γ-phosphate of NTPs is bioreversibly modified. A series of TriPPPro-compounds bearing two lipophilic masking...
Xiangyang Zhang et al.
Analytical biochemistry, 485, 81-85 (2015-06-15)
A new polymer bearing aldehyde groups was designed and synthesized by grafting 4-pyridinecarboxaldehyde onto poly(epichlorohydrin). Antibodies can be directly immobilized on the surface of the polymer film through the covalent bonding of aldehyde groups of the film with amino groups...
Hao-Yang Mi et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(5), 960-970 (2014-09-02)
Soft and hard thermoplastic polyurethane (TPU) and their blends were electrospun to fabricate nanofibrous scaffolds with various properties in order to investigate the substrate property effects on cellular response. The scaffolds were characterized with Fourier transform infrared spectroscopy, thermogravimetric analysis...
Mauricio Mora-Pale et al.
Biotechnology and bioengineering, 112(12), 2417-2428 (2015-06-26)
Plant polyphenols are known to have varying antimicrobial potencies, including direct antibacterial activity, synergism with antibiotics and suppression of bacterial virulence. We performed the in vitro oligomerization of resveratrol catalyzed by soybean peroxidase, and the two isomers (resveratrol-trans-dihydrodimer and pallidol)...
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