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Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway.
Markovics, JA; Araya, J; Cambier, S; Jablons, D; Hill, A; Wolters, PJ; Nishimura, SL
The Journal of Biological Chemistry null
Young-Jun Park et al.
PLoS pathogens, 9(10), e1003646-e1003646 (2013-10-08)
Thioredoxin-interacting protein (TXNIP) has multiple functions, including tumor suppression and involvement in cell proliferation and apoptosis. However, its role in the inflammatory process remains unclear. In this report, we demonstrate that Txnip⁻/⁻ mice are significantly more susceptible to lipopolysaccharide (LPS)-induced
The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination.
Kogure, M; Takawa, M; Saloura, V; Sone, K; Piao, L; Ueda, K; Ibrahim, R; Tsunoda et al.
Neoplasia null
Suidong Ouyang et al.
JCI insight, 5(3) (2020-02-14)
IL-17A plays a critical role in the pathogenesis of steroid-resistant neutrophilic airway inflammation, which is a hallmark of severe asthma and chronic obstructive pulmonary disease (COPD). Through RNA sequencing analysis of transcriptomes of human airway smooth muscle cells treated with
Role of the serum response factor in regulating contractile apparatus gene expression and sarcomeric integrity in cardiomyocytes.
Robert O Balza, Ravi P Misra
The Journal of Biological Chemistry null
Shin Hamada et al.
Journal of cellular physiology, 227(2), 729-738 (2011-04-06)
Pancreatic cancer is one of the life-threatening cancers due to the difficulty in the curative surgery and resistance against conventional therapeutic strategies. Recent studies indicated that cancer stem cells, which exist as a small number of cells within the entire
Orexin signaling mediates the antidepressant-like effect of calorie restriction.
Lutter, M; Krishnan, V; Russo, SJ; Jung, S; McClung, CA; Nestler, EJ
The Journal of Neuroscience null
Increased expression of hepatocyte nuclear factor 6 stimulates hepatocyte proliferation during mouse liver regeneration.
Yongjun Tan, Yuichi Yoshida, Douglas E Hughes, Robert H Costa
Gastroenterology null
Jiadong Wang et al.
The Journal of biological chemistry, 288(5), 3174-3183 (2012-12-12)
Mutation of PHF6, which results in the X-linked mental retardation disorder Börjeson-Forssman-Lehmann syndrome, is also present in about 38% of adult T-cell acute lymphoblastic leukemias and 3% of adult acute myeloid leukemias. However, it remains to be determined exactly how
Veronika Foltánková et al.
Gene, 522(2), 156-167 (2013-04-10)
DNA repair events have functional significance especially for genome stability. Although the DNA damage response within the whole genome has been extensively studied, the region-specific characteristics of nuclear sub-compartments such as the nucleolus or fragile sites have not been fully
Adrian Achuthan et al.
The Journal of clinical investigation, 126(9), 3453-3466 (2016-08-16)
Data from preclinical and clinical studies have demonstrated that granulocyte macrophage colony-stimulating factor (GM-CSF) can function as a key proinflammatory cytokine. However, therapies that directly target GM-CSF function could lead to undesirable side effects, creating a need to delineate downstream
J M Westberry et al.
Neuroscience, 152(4), 982-989 (2008-03-21)
Permanent middle cerebral artery occlusion (MCAO) causes neuronal cell death in the striatum and cortex. In rodents, estradiol treatment protects the cortex from cell death in an estrogen receptor alpha (ERalpha) dependent manner. ERalpha is only transiently expressed in the
Negative regulation of inducible nitric-oxide synthase expression mediated through transforming growth factor-beta-dependent modulation of transcription factor TCF11.
David T Berg, Akanksha Gupta, Mark A Richardson, Lee A O'Brien, David Calnek, Brian W Grinnell
The Journal of Biological Chemistry null
Xiangqi Meng et al.
Nature communications, 11(1), 594-594 (2020-02-01)
Activation of receptor tyrosine kinase (RTK) protein is frequently observed in malignant progression of gliomas. In this study, the crosstalk activation of epidermal growth factor receptor (EGFR) and mesenchymal-epithelial transition factor (MET) signaling pathways is demonstrated to contribute to temozolomide
Epigenetic regulation of the endothelial nitric oxide synthase gene in persistent pulmonary hypertension of the newborn rat.
Xu, XF; Ma, XL; Shen, Z; Wu, XL; Cheng, F; Du, LZ
Journal of Hypertension null
Sungsin Jo et al.
Cells, 9(1) (2020-01-23)
1α,25-dihydroxyvitamin D3 (1,25D3), the most popular drug for osteoporosis treatment, drives osteoblast differentiation and bone mineralization. Wnt/β-catenin signaling is involved in commitment and differentiation of osteoblasts, but the role of the Dickkopf-related protein 1 (DKK1), a Wnt antagonist, in osteoblasts
Nrf2-dependent induction of proteasome and Pa28?? regulator are required for adaptation to oxidative stress.
Andrew M Pickering,Robert A Linder,Hongqiao Zhang,Henry J Forman,Kelvin J A Davies
The Journal of Biological Chemistry null
Haibin Zhu et al.
Endocrinology, 157(9), 3529-3539 (2016-07-06)
The cortisol-inactivating enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) that catalyzes the intracellular inactivation of glucocorticoids plays a pivotal role in human pregnant maintenance and normal fetal development. Given the fact that the main components of Hedgehog (HH) signaling pathway are
Early growth response gene-1 plays a pivotal role in down-regulation of a cohort of genes in uterine leiomyoma.
Hiroshi Ishikawa, Makio Shozu, Masahiko Okada, Mai Inukai, Bo Zhang, Keiichi Kato et al.
Journal of Molecular Endocrinology null
André Kleinridders et al.
The Journal of clinical investigation, 123(11), 4667-4680 (2013-10-03)
Type 2 diabetes is characterized by insulin resistance and mitochondrial dysfunction in classical target tissues such as muscle, fat, and liver. Using a murine model of type 2 diabetes, we show that there is hypothalamic insulin resistance and mitochondrial dysfunction
A central role for transcription factor C/EBP-beta in regulating CD1d gene expression in human keratinocytes.
Hashmat Sikder, Yuming Zhao, Anna Balato, Andre Chapoval, Rita Fishelevich, Padmaja Gade et al.
Journal of immunology (Baltimore, Md. : 1950) (1950)
Gengze Wu et al.
Circulation, 130(17), 1452-1465 (2014-08-27)
Long noncoding RNAs (lncRNAs) have recently been implicated in many biological processes and diseases. Atherosclerosis is a major risk factor for cardiovascular disease. However, the functional role of lncRNAs in atherosclerosis is largely unknown. We identified lincRNA-p21 as a key
I Manabe et al.
The Journal of clinical investigation, 107(7), 823-834 (2001-04-04)
Expression of smooth muscle myosin heavy chain (SM-MHC) is tightly controlled depending on the differentiated state of smooth muscle cells (SMCs). To better understand the mechanisms that regulate transcription of the SM-MHC gene in vivo, we tested the function of
Domenick E Kennedy et al.
Nature immunology, 21(6), 660-670 (2020-04-29)
Within germinal centers (GCs), complex and highly orchestrated molecular programs must balance proliferation, somatic hypermutation and selection to both provide effective humoral immunity and to protect against genomic instability and neoplastic transformation. In contrast to this complexity, GC B cells
Supriya K Saha et al.
Nature, 513(7516), 110-114 (2014-07-22)
Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are among the most common genetic alterations in intrahepatic cholangiocarcinoma (IHCC), a deadly liver cancer. Mutant IDH proteins in IHCC and other malignancies acquire an abnormal enzymatic activity allowing them to convert
A novel cis-acting element in Her2 promoter regulated by Stat3 in mammary cancer cells
Qian, Lu, et al
Biochemical and biophysical research communications null
Transcriptional silencing of nonsense codon-containing immunoglobulin micro genes requires translation of its mRNA.
Lukas Stalder,Oliver Muhlemann
The Journal of Biological Chemistry null
Zhiqiang Pan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(9), 2769-2781 (2016-03-05)
DNA 5-hydroxylmethylcytosine (5hmC) catalyzed by ten-eleven translocation methylcytosine dioxygenase (TET) occurs abundantly in neurons of mammals. However, the in vivo causal link between TET dysregulation and nociceptive modulation has not been established. Here, we found that spinal TET1 and TET3
Zengdun Shi et al.
American journal of physiology. Gastrointestinal and liver physiology, 318(3), G504-G517 (2020-01-14)
Activation of hepatic stellate cells (HSCs), characterized by development of a robust actin cytoskeleton and expression of abundant extracellular matrix (ECM) proteins, such as type 1 collagen (COL.1), is a central cellular and molecular event in liver fibrosis. It has
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