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Marwa Hentati-Kallel et al.
International journal of oncology, 50(2), 717-726 (2016-12-31)
Glucocorticoids are largely used in the treatment of inflammatory pathologies and/or hematological malignancies and regulate the expression of a variety of genes involved in inflammation or metastasis such as matrix metalloproteinases (MMP). Long-term exposure to glucocorticoids can result in failure of
Urbain Weyemi et al.
Nature communications, 7, 10711-10711 (2016-02-16)
The epithelial-mesenchymal transition (EMT), considered essential for metastatic cancer, has been a focus of much research, but important questions remain. Here, we show that silencing or removing H2A.X, a histone H2A variant involved in cellular DNA repair and robust growth
MicroRNAs as Big Regulators of Neural Stem/Progenitor Cell Proliferation, Differentiation and Migration: A Potential Treatment for Stroke.
Zhang, Q; Zhang, K; Zhang, C; Ge, H; Yin, Y; Feng, H; Hu, R
Current Pharmaceutical Design null
Wei Guo et al.
Molecular and cellular biology, 36(16), 2141-2141 (2016-05-25)
Lung alveolar type II cells uniquely synthesize surfactant, a developmentally regulated lipoprotein that is essential for breathing. Expression of the gene (SFTPA) encoding the major surfactant protein, SP-A, in midgestation human fetal lung (HFL) is dramatically induced by cyclic AMP
HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas.
Sun, M; Tong, P; Kong, W; Dong, B; Huang, Y; Park, IY; Zhou, L; Liu, XD; Ding, Z; Zhang et al.
Cancer Research null
MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells.
Li, CX; Talele, NP; Boo, S; Koehler, A; Knee-Walden, E; Balestrini, JL; Speight, P; Kapus et al.
Nature Materials null
Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments.
Angelin, A; Gil-de-Gomez, L; Dahiya, S; Jiao, J; Guo, L; Levine, MH; Wang, Z; Quinn et al.
Cell Metabolism null
Xin Wang et al.
Nature communications, 11(1), 1141-1141 (2020-03-01)
Osteosarcoma, an aggressive malignant cancer, has a high lung metastasis rate and lacks therapeutic target. Here, we reported that chromobox homolog 4 (CBX4) was overexpressed in osteosarcoma cell lines and tissues. CBX4 promoted metastasis by transcriptionally up-regulating Runx2 via the
CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease.
Jin, N; Qian, W; Yin, X; Zhang, L; Iqbal, K; Grundke-Iqbal, I; Gong, CX; Liu, F
Nucleic Acids Research null
Mika Bando et al.
Biochimica et biophysica acta, 1829(9), 954-962 (2013-04-09)
S100A9 is a calcium-binding protein and subunit of antimicrobial calprotectin complex (S100A8/A9). Produced by neutrophils, monocytes/macrophages and keratinocytes, S100A9 expression increases in response to inflammation. For example, IL-1α produced by epithelial cells acts autonomously on the same cells to induce
Feng-Sheng Wang et al.
Journal of molecular medicine (Berlin, Germany), 95(5), 499-512 (2017-01-29)
Excess glucocorticoid administration impairs osteogenic activities, which raises the risk of osteoporotic disorders. Epigenetic methylation of DNA and histone regulates the lineage commitment of progenitor cells. This study was undertaken to delineate the actions of histone lysine demethylase 6a (UTX)
Human ?-defensin expression is not dependent on CCAAT/enhancer binding protein-? in a murine model.
Glenth?j, A; Dahl, S; Larsen, MT; Cowland, JB; Borregaard, N
Testing null
Ritu Mishra et al.
Molecular and cellular biology, 38(11) (2018-03-07)
The major surfactant protein, SP-A (a product of the SFTPA gene), serves as a marker of type II pneumocyte differentiation and surfactant synthesis. SFTPA expression in cultured human fetal lung (HFL) epithelial cells is upregulated by hormones that increase cyclic
Guo-Dong Ye et al.
Gastroenterology, 150(3), 659-671 (2015-12-02)
Activation of WNT signaling promotes the invasive activities of several types of cancer cells, but it is not clear if it regulates the same processes in colorectal cancer (CRC) cells, or what mechanisms are involved. We studied the expression and
Madeleen Bosma et al.
Nature communications, 7, 11314-11314 (2016-04-14)
FNDC4 is a secreted factor sharing high homology with the exercise-associated myokine irisin (FNDC5). Here we report that Fndc4 is robustly upregulated in several mouse models of inflammation as well as in human inflammatory conditions. Specifically, FNDC4 levels are increased
Yunmin Li et al.
Human molecular genetics, 26(5), 901-912 (2017-02-09)
The gonadoblastoma gene, testis-specific protein Y-encoded (TSPY), on the Y chromosome and its X-homologue, TSPX, are cell cycle regulators and function as a proto-oncogene and a tumor suppressor respectively in human oncogenesis. TSPY and TSPX competitively bind to the androgen
Min Guan et al.
PloS one, 12(6), e0179692-e0179692 (2017-06-28)
SK-UT-1 uterine leiomyosarcomas (Ut-LMS) cells were transduced with a fatty acid synthase (FASN)-containing retroviral vector to recapitulate the "lipogenic phenotype of cancer." Consistent with this model, forced expression of FASN enhanced SK-UT-1 proliferation, migration, and cellular motion. Further investigation showed
HBL1 Is a Human Long Noncoding RNA that Modulates Cardiomyocyte Development from Pluripotent Stem Cells by Counteracting MIR1.
Liu, J; Li, Y; Lin, B; Sheng, Y; Yang, L
Developmental Cell null
Ancheng Qin et al.
Biochemical and biophysical research communications, 457(4), 681-687 (2015-01-27)
Chemotherapeutic resistance indicated the poor prognosis of colorectal cancer. Our study aimed to investigate the role of STAT3/cyclinD1 pathway in the chemotherapeutic resistance of colorectal cancer. We firstly measured the expression of cyclinD1 in the colorectal cancer tissues using immunohistochemistry
Bairu Wang et al.
Archives of toxicology, 90(2), 449-461 (2014-12-21)
Abnormal expression of miRNAs has been implicated in the pathogenesis of human lung cancers, most of which are attributable to cigarette smoke. The mechanisms of action, however, remain obscure. Here, we report that there are decreased expression of miR-218 and
The cross-talk between canonical and non-canonical Wnt-dependent pathways regulates P-glycoprotein expression in human blood-brain barrier cells.
Pinzon-Daza, ML; Salaroglio, IC; Kopecka, J; Garzon, R; Couraud, PO; Ghigo, D; Riganti, C
Journal of Cerebral Blood Flow and Metabolism null
Acute hyperglycemia impairs functional improvement after spinal cord injury in mice and humans.
Kobayakawa, K; Kumamaru, H; Saiwai, H; Kubota, K; Ohkawa, Y; Kishimoto, J; Yokota et al.
Science Translational Medicine null
Oncogenic KRAS Targets MUC16/CA125 in Pancreatic Ductal Adenocarcinoma.
Liang, C; Qin, Y; Zhang, B; Ji, S; Shi, S; Xu, W; Liu, J; Xiang, J; Liang, D; Hu, Q; Ni et al.
Molecular Cancer Research null
Giulia Milan et al.
Nature communications, 6, 6670-6670 (2015-04-11)
Stresses like low nutrients, systemic inflammation, cancer or infections provoke a catabolic state characterized by enhanced muscle proteolysis and amino acid release to sustain liver gluconeogenesis and tissue protein synthesis. These conditions activate the family of Forkhead Box (Fox) O
LncRNA PVT1 epigenetically silences miR-195 and modulates EMT and chemoresistance in cervical cancer cells.
Shen, CJ; Cheng, YM; Wang, CL
Journal of Drug Targeting null
W Tang et al.
British journal of cancer, 110(2), 450-458 (2013-11-28)
Growing evidence suggests that miR-29a has an important role in regulating tumourigenesis and development of various types of cancer. However, the role and the underlying mechanism of miR-29a in colorectal cancer (CRC) remain largely unknown. MiR-29a targeted gene was identified
MPC1, a key gene in cancer metabolism, is regulated by COUPTFII in human prostate cancer.
Wang, L; Xu, M; Qin, J; Lin, SC; Lee, HJ; Tsai, SY; Tsai, MJ
Oncotarget null
Rachel Hood Edwards et al.
mBio, 6(2) (2015-04-16)
The Epstein-Barr virus protein latent membrane protein 1 (LMP1) has two NF-κB activating domains within its intracellular carboxy terminus (carboxy-terminal activating region 1 [CTAR1] and CTAR2). LMP1-CTAR1 is required for B-lymphocyte transformation, is capable of transforming rodent fibroblasts, and uniquely
Kuo-Ting Sun et al.
Bone, 73, 145-153 (2014-12-09)
Autophagy and autophagy-related proteins (ATGs) play decisive roles in osteoclast differentiation. Emerging lines of evidence show the deregulation of miRNA in autophagic responses. However, the role of hypoxia and involvement of miRNA in osteoclast differentiation are unclear. In the present
Suppressor of sable [Su(s)] and Wdr82 down-regulate RNA from heat-shock-inducible repetitive elements by a mechanism that involves transcription termination.
Brewer-Jensen, P; Wilson, CB; Abernethy, J; Mollison, L; Card, S; Searles, LL
RNA null
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