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Wagner Hummig et al.
Journal of oral & facial pain and headache, 28(4), 350-359 (2014-10-28)
To assess the analgesic effect of pregabalin in orofacial models of acute inflammatory pain and of persistent pain associated with nerve injury and cancer, and so determine its effectiveness in controlling orofacial pains having different underlying mechanisms. Orofacial capsaicin and
The heat is on: does direct application of capsaicin to autonomic nerves produce a specific deafferentation?
Helen E Raybould
The Journal of physiology, 591(6), 1405-1405 (2013-03-19)
S W Hwang et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(11), 6155-6160 (2000-05-24)
Capsaicin, a pungent ingredient of hot peppers, causes excitation of small sensory neurons, and thereby produces severe pain. A nonselective cation channel activated by capsaicin has been identified in sensory neurons and a cDNA encoding the channel has been cloned
G Weekes et al.
Irish medical journal, 106(3), 89-90 (2013-08-21)
Qutenza is a high potency capsaicin topical patch which has been recommended for the treatment of peripheral neuropathic pain. The aim of this study was to assess our selected patients' response to Qutenza application. All patients had their dynamic pain
Björn Rathsman et al.
Diabetologia, 57(8), 1703-1710 (2014-05-08)
We investigated skin microcirculation and its association with HbA1c and the incidence of ischaemic foot ulcer in patients with type 1 diabetes formerly randomised (1982-1984) to intensified conventional treatment (ICT) or standard treatment (ST) with insulin for a mean of
Seungwon Choi et al.
Neuron, 78(5), 869-880 (2013-06-15)
Animals undergo periods of behavioral quiescence and arousal in response to environmental, circadian, or developmental cues. During larval molts, C. elegans undergoes a period of profound behavioral quiescence termed lethargus. Locomotion quiescence during lethargus was abolished in mutants lacking a
Stefano Evangelista
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 68, 259-276 (2014-06-20)
Calcitonin gene-related peptide (CGRP), a 37 aminoacid-residue peptide, is a marker of afferent fibers in the upper gastrointestinal tract, being almost completely depleted following treatment with the selective neurotoxin capsaicin that targets these fibers via transient receptor potential vanilloid type-1
Johannes Wohlrab et al.
Skin pharmacology and physiology, 28(2), 65-74 (2014-10-04)
Epicutaneous application of capsaicin causes a long-lasting analgesic effect by binding to the membrane transient receptor potential vanilloid 1 (TRPV1) on mechanoheat-sensitive C and Aδ fibres, changing axonal integrity and inhibiting neurogenic inflammatory processes. To date, no information is available
Kinga Sałat et al.
Pharmacology, biochemistry, and behavior, 122, 173-181 (2014-04-15)
Anticancer drugs - oxaliplatin (OXPT) and paclitaxel (PACLI) cause painful peripheral neuropathy activating Transient Receptor Potential (TRP) channels. Here we investigated the influence of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one (LPP1) and pregabalin on nociceptive thresholds in neuropathic pain models elicited by these drugs. Pharmacokinetics
M Couto et al.
Journal of investigational allergology & clinical immunology, 23(5), 289-301 (2013-11-23)
A high parasympathetic tone leading to bronchoconstriction and neurogenic inflammation is thought to have a major role in the pathogenesis of asthma. Transient receptor potential vanilloid 1 (TRPV1) is the hub of almost all neuronal inflammatory signaling pathways. A critical
Howard Smith et al.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 68, 129-146 (2014-06-20)
The TRPV1 receptor is known to play a role in nociceptive transmission in multiple organ systems, usually in response to the pain of inflammation. TRPV1 antagonism has so far shown limited benefit in antinociception. Capsaicin, a TRPV1 agonist, has been
Louisa Pettinger et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(26), 10762-10771 (2013-06-28)
Analgesics targeting the δ-opioid receptor (DOR) may lead to fewer side effects than conventional opioid drugs, which mainly act on μ-opioid receptors (MOR), because of the less abundant expression of DOR in the CNS compared with MOR. Analgesic potential of
Xinying Jia et al.
FEBS letters, 588(17), 3047-3054 (2014-06-17)
The airway epithelium is exposed to a range of irritants in the environment that are known to trigger inflammatory response such as asthma. Transient receptor potential vanilloid 1 (TRPV1) is a Ca(2+)-permeable cation channel critical for detecting noxious stimuli by
Nathan Robbins et al.
Translational research : the journal of laboratory and clinical medicine, 161(6), 469-476 (2013-03-05)
Cardiovascular disease is a leading cause of morbidity and mortality worldwide, encompassing a variety of cardiac and vascular conditions. Transient receptor potential vanilloid (TRPV) channels, specifically TRPV type 1 (TRPV1) and TRPV type 2 (TRPV2), are relatively recently described channels
Ruo-Xiao Cheng et al.
Theranostics, 9(15), 4287-4307 (2019-07-10)
Methylglyoxal (MGO), an endogenous reactive carbonyl compound, plays a key role in the pathogenesis of diabetic neuropathy. The aim of this study is to investigate the role of MGO in diabetic itch and hypoalgesia, two common symptoms associated with diabetic
Viktor Lukacs et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(28), 11451-11463 (2013-07-12)
Transient Receptor Potential Vanilloid 1 (TRPV1) is a polymodal, Ca(2+)-permeable cation channel crucial to regulation of nociceptor responsiveness. Sensitization of TRPV1 by G-protein coupled receptor (GPCR) agonists to its endogenous activators, such as low pH and noxious heat, is a
Andrés Jara-Oseguera et al.
The Journal of general physiology, 132(5), 547-562 (2008-10-29)
The transient receptor potential vanilloid 1 (TRPV1) nonselective cationic channel is a polymodal receptor that activates in response to a wide variety of stimuli. To date, little structural information about this channel is available. Here, we used quaternary ammonium ions
Zohar Bromberg et al.
PloS one, 8(2), e57149-e57149 (2013-03-08)
The heat shock response (HSR) is a highly conserved molecular response to various types of stresses, including heat shock, during which heat-shock proteins (Hsps) are produced to prevent and repair damages in labile proteins and membranes. In cells, protein unfolding
Chun-Chun Hsu et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(7), R769-R779 (2013-07-12)
The sensitization of capsaicin-sensitive lung vagal (CSLV) afferents by inflammatory mediators is important in the development of airway hypersensitivity. Hydrogen sulfide (H2S) is an endogenous mediator inducing hyperalgesia through transient receptor potential ankyrin 1 (TRPA1) receptors located on nociceptors. We
Kristian Gaarn du Jardin et al.
Pain research & management, 18(1), 6-10 (2013-03-05)
Dynamic mechanical allodynia is traditionally induced by manual brushing of the skin. Brushing force and speed have been shown to influence the intensity of brush-evoked pain. There are still limited data available with respect to the optimal stroke number, length
Luis E Gonzalez-Reyes et al.
Experimental neurology, 250, 321-332 (2013-10-23)
Transient receptor potential vanilloid 1 (TRPV1) is a cation-permeable ion channel found in the peripheral and central nervous systems. The membrane surface expression of TRPV1 is known to occur in neuronal cell bodies and sensory neuron axons. TRPV1 receptors are
Umesh Singh et al.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 68, 147-170 (2014-06-20)
Capsaicin is a selective transient receptor potential vanilloid 1 (TRPV1) ion channel agonist and has been demonstrated to reduce nerve conduction of nociceptive C fibers in the trigeminal nerve without affecting conduction in Adelta fibers. This chapter reviews the classification
Fufang Kushen injection inhibits sarcoma growth and tumor-induced hyperalgesia via TRPV1 signaling pathways.
Zhao Z, Fan H, Higgins T, et al.
Cancer Letters, 355(2), 232-241 (2014)
Michael J M Fischer et al.
Pflugers Archiv : European journal of physiology, 466(12), 2229-2241 (2014-03-20)
Transient receptor potential cation channel, subfamily V, member 1 (TRPV1) plays a key role in sensing environmental hazards and in enhanced pain sensation following inflammation. A considerable proportion of TRPV1-expressing cells also express transient receptor potential cation channel, subfamily A
Complex generalized instead of complex regional?
Tanja Schlereth et al.
Anesthesiology, 120(5), 1078-1079 (2014-03-14)
Arafat Nasser et al.
Neuroscience letters, 584, 247-252 (2014-12-03)
Tetrahydrobiopterin (BH4) is implicated in the development and maintenance of chronic pain. After injury/inflammation, the biosynthesis of BH4 is markedly increased in sensory neurons, and the pharmacological and genetic inhibition of BH4 shows analgesic effects in pre-clinical animal pain models.
Matthew Baxter et al.
Thorax, 69(12), 1080-1089 (2014-10-11)
COPD is an inflammatory disease usually associated with cigarette smoking (CS) with an increasing global prevalence and no effective medication. Extracellular ATP is increased in the COPD affected lung and may play a key role in driving CS-induced airway inflammation
Takeshi Shima et al.
American journal of physiology. Gastrointestinal and liver physiology, 306(9), G811-G818 (2014-03-22)
A well-developed myenteric plexus exists in the esophagus composed of striated muscle layers, but its functional role in controlling peristaltic movements remains to be clarified. The purpose of this study was to clarify the role of a local neural reflex
R-D Treede et al.
Current medical research and opinion, 29(5), 527-538 (2013-03-01)
The capsaicin 8% cutaneous patch is an emergent new treatment option for patients with peripheral neuropathic pain. In randomized controlled clinical studies relevant pain relief for 12 weeks was achieved in about one third of patients following a single application.
Gemma Mazzuoli et al.
The Journal of physiology, 587(Pt 19), 4681-4694 (2009-08-26)
An important feature of the enteric nervous system (ENS) is its capability to respond to mechanical stimulation which, as currently suggested for the guinea-pig ileum, is encoded by specialized intrinsic primary afferent neurons (IPANs). We used von Frey hairs or
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