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1086006

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Zhi-Wei Chen et al.
Nucleic acids research, 42(18), 11560-11569 (2014-09-25)
Human single-strand (ss) DNA binding proteins 1 (hSSB1) has been shown to participate in DNA damage response and maintenance of genome stability by regulating the initiation of ATM-dependent signaling. ATM phosphorylates hSSB1 and prevents hSSB1 from ubiquitin-proteasome-mediated degradation. However, the
Kathrin Arnhard et al.
Analytical and bioanalytical chemistry, 407(2), 405-414 (2014-11-05)
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has become an indispensable analytical technique in clinical and forensic toxicology for detection and identification of potentially toxic or harmful compounds. Particularly, non-target LC-MS/MS assays enable extensive and universal screening requested in systematic toxicological analysis.
Khrystyna Yu Sukhanova et al.
Pharmacological reports : PR, 66(3), 363-372 (2014-06-07)
ATP is one of the principal sympathetic neurotransmitters which contracts vascular smooth muscle cells (SMCs) via activation of ionotropic P2X receptors (P2XRs). We have recently demonstrated that contraction of the guinea pig small mesenteric arteries evoked by stimulation of P2XRs
Margarida Galhetas et al.
Journal of colloid and interface science, 433, 94-103 (2014-08-13)
The high carbon contents and low toxicity levels of chars from coal and pine gasification provide an incentive to consider their use as precursors of porous carbons obtained by chemical activation with K2CO3. Given the chars characteristics, previous demineralization and
Pragalathan Naidoo et al.
Pharmacological reports : PR, 66(4), 585-593 (2014-06-21)
The aim of the present study was to develop an alternative non-obese non-genetic rat model of type 2 diabetes (T2D). Six-week-old male SD rats were randomly divided into six groups, namely: Normal Control (NC), Diabetic Control (DBC), Caffeine 5mg/kg BW+STZ
Chuanhai Cao et al.
Journal of Alzheimer's disease : JAD, 42(3), 973-984 (2014-07-16)
The purpose of this study was to investigate the potential therapeutic qualities of Δ9-tetrahydrocannabinol (THC) with respect to slowing or halting the hallmark characteristics of Alzheimer's disease. N2a-variant amyloid-β protein precursor (AβPP) cells were incubated with THC and assayed for
Timing of caffeine therapy in very low birth weight infants.
Barbara Schmidt et al.
The Journal of pediatrics, 164(5), 957-958 (2014-03-19)
Ziv Lifshitz et al.
Infection and immunity, 82(9), 3740-3752 (2014-06-25)
Coxiella burnetii, the causative agent of Q fever, is a human intracellular pathogen that utilizes the Icm/Dot type IVB secretion system to translocate effector proteins into host cells. To identify novel C. burnetii effectors, we applied a machine-learning approach to
Jie Ping et al.
Toxicology, 321, 53-61 (2014-04-11)
Prenatal caffeine ingestion is one of the risk factors for intrauterine growth retardation (IUGR). Adrenal plays a pivotal role, mainly through steroidogenesis, in the regulation of intrauterine homeostasis and in fetal development and maturation. We have shown that prenatal caffeine
Luiz Augusto da Silva et al.
Pharmaceutical biology, 52(8), 956-960 (2014-03-08)
Caffeine can stimulate insulin secretion by attenuating hyperglycemia in diabetes models with significant reduction of pancreatic functional β cells. Knowledge of these mechanisms could contribute to new strategies for treating diabetes. This study evaluated the effects of caffeine and physical
Brian A Mc Ardle et al.
Circulation. Cardiovascular imaging, 7(6), 930-937 (2014-09-04)
Cardiac allograft vasculopathy is a key prognostic determinant after heart transplant. Detection and risk stratification of patients with cardiac allograft vasculopathy are problematic. Positron emission tomography using rubidium-82 allows quantification of absolute myocardial blood flow and may have utility for
Tom M McLellan et al.
Nutrition reviews, 70(12), 730-744 (2012-12-05)
Energy drinks (EDs) contain caffeine and are a new, popular category of beverage. It has been suggested that EDs enhance physical and cognitive performance; however, it is unclear whether the claimed benefits are attributable to components other than caffeine. A
Robert Lemery et al.
Journal of cardiovascular electrophysiology, 26(1), 1-6 (2014-08-02)
Patients with cardiac arrhythmias are generally instructed to avoid caffeine intake. A comprehensive evaluation of the electrophysiological effects of caffeine on atrial and ventricular tissues in humans has not previously been performed. Eighty patients (31 men, mean age 49 ± 14 years) with symptomatic
Laureen Colis et al.
Oncotarget, 5(12), 4361-4369 (2014-06-24)
DNA intercalation is a major therapeutic modality for cancer therapeutic drugs. The therapeutic activity comes at a cost of normal tissue toxicity and genotoxicity. We have recently described a planar heterocyclic small molecule DNA intercalator, BMH-21, that binds ribosomal DNA
Joshi John et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(6), R704-R710 (2014-07-18)
Histamine neurons are active during waking and largely inactive during sleep, with minimal activity during rapid-eye movement (REM) sleep. Caffeine, the most widely used stimulant, causes a significant increase of sleep onset latency in rats and humans. We hypothesized that
Peter Stokes et al.
Rapid communications in mass spectrometry : RCM, 28(18), 2024-2030 (2014-08-19)
The atmospheric pressure solids analysis probe (ASAP) has been successfully introduced into laboratories as a routine analytical tool but the technique is labour-intensive and is not easily automated. This paper describes the modifications made to an existing atmospheric pressure gas
Seema B Jabbar et al.
The American journal of forensic medicine and pathology, 34(4), 321-324 (2013-11-08)
Caffeine is a central nervous system stimulant that is consumed by large numbers of people on a routine basis, usually in the form of coffee or tea. However, if consumed in high doses, this xanthine alkaloid is profoundly toxic and
Severe hypertension related to caffeinated coffee and tranylcypromine: a case report.
Niels van der Hoeven et al.
Annals of internal medicine, 160(9), 657-658 (2014-05-07)
How does coffee prevent liver fibrosis? Biological plausibility for recent epidemiological observations.
Jonathan A Dranoff et al.
Hepatology (Baltimore, Md.), 60(2), 464-467 (2014-01-28)
Jong-Yun Kim et al.
Oncology reports, 33(5), 2639-2647 (2015-03-31)
Styrylquinazolines are synthetic analogues of resveratrol and have been suggested to cause anti-inflammatory activity by modulating prostaglandin E₂ (PGE₂) production. In the present study, we evaluated cytotoxic effects of various styrylquinazoline derivatives and found that (E)-8-acetoxy-2-[2-(3,4-diacetoxyphenyl)ethenyl]-quinazoline (8-ADEQ) most potently inhibited
Laurel K Dodgen et al.
Environmental pollution (Barking, Essex : 1987), 198, 144-153 (2015-01-17)
The reuse of treated wastewater for agricultural irrigation in arid and hot climates where plant transpiration is high may affect plant accumulation of pharmaceutical and personal care products (PPCPs) and endocrine disrupting chemicals (EDCs). In this study, carrot, lettuce, and
Jasbir D Upadhyaya et al.
PloS one, 9(10), e110373-e110373 (2014-10-24)
Activation of bitter taste receptors (T2Rs) in human airway smooth muscle cells leads to muscle relaxation and bronchodilation. This finding led to our hypothesis that T2Rs are expressed in human pulmonary artery smooth muscle cells and might be involved in
Ayuko Imaoka et al.
Drug metabolism and pharmacokinetics, 29(5), 414-418 (2014-05-09)
The drug interaction between new quinolone antibiotics (NQs) and polyvalent metal cation products, leading to a significant decrease in the absorption of NQ, is considered to be attributable to the formation of poorly absorbable chelate and physicochemical adsorption of NQs
Virginia G de Yébenes et al.
Blood, 124(2), 229-239 (2014-05-23)
microRNAs are a class of regulators of gene expression that have been shown critical for a great number of biological processes; however, little is known of their role in germinal center (GC) B cells. Although the GC reaction is crucial
Barbara L Walton et al.
Analytical chemistry, 86(16), 8114-8120 (2014-07-11)
Matrix-assisted laser desorption ionization (MALDI) imaging is gaining popularity, but matrix effects such as mass spectral interference and damage to the sample limit its applications. Replacing traditional matrices with silver particles capable of equivalent or increased photon energy absorption from
K U Petersen
MMW Fortschritte der Medizin, 155 Suppl 4, 109-114 (2014-06-18)
Caffeine as an analgesic adiuvant has been discussed for many years. In a recent Cochrane review based on 19 studies with a total of 7238 patients, caffeine enhanced the efficacy of paracetamol, ibuprofen or aspirin with a number needed to
Lóránd Kiss et al.
Journal of pharmaceutical sciences, 103(10), 3107-3119 (2014-07-22)
Sucrose fatty acid esters are increasingly used as excipients in pharmaceutical products, but few data are available on their toxicity profile, mode of action, and efficacy on intestinal epithelial models. Three water-soluble sucrose esters, palmitate (P-1695), myristate (M-1695), laurate (D-1216)
Paul S Regier et al.
Drug and alcohol dependence, 143, 58-64 (2014-07-31)
Previous research indicates that individual differences in traits such as impulsivity, avidity for sweets, and novelty reactivity are predictors of several aspects of drug addiction. Specifically, rats that rank high on these behavioral measures are more likely than their low
N Whitehead et al.
Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 26(2), 111-125 (2013-01-22)
Compounds other than macronutrients have been shown to influence blood glucose concentrations and insulin sensitivity in people with diabetes, with caffeine being one such substance. The present study systematically reviewed the evidence of the effects of caffeine on blood glucose
Rong Zhou et al.
Acta pharmacologica Sinica, 35(11), 1375-1384 (2014-09-30)
Ryanodine receptor 2 (RyR2) is a critical component of intracellular Ca(2+) signaling in vascular smooth muscle cells (VSMCs). The aim of this study was to investigate the role of RyR2 in abnormal vascular reactivity after hemorrhagic shock in rats. SD
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